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• W2047246164 startingPage "296" @default.
• W2047246164 abstract "Increased body weight is often accompanied by increased circulating levels of leptin and glucose, which alters glucose metabolism in various tissues, including perhaps the oocyte. Alteration of glucose metabolism impacts oocyte function and may contribute to the subfertility often associated with obese individuals. The objective of this study was to determine the effect of leptin (0, 10, and 100 ng/ml) on the oocyte and cumulus cells during in vitro maturation under differing glucose concentrations. We examined the effects of leptin on oocyte maturation, blastocyst development, and/or gene expression in oocytes and cumulus cells (IRS1, IGF1, PPARγ, IL6, GLUT1) in a physiological glucose (2 mM) and high glucose (50 mM) environment. We also evaluated the effect of leptin on glucose metabolism via glycolysis and the pentose phosphate pathway. In a physiological glucose environment, leptin did not have an influence on oocyte maturation, blastocyst development, or oocyte gene expression. Expression of GLUT1 in cumulus cells was downregulated with 100 ng/ml leptin treatment, but did not affect oocyte glucose metabolism. In a high glucose environment, oocyte maturation and glycolysis were decreased, but in the presence of 100 ng/ml leptin, these parameters were improved to levels similar to control. This effect is potentially mediated by an upregulation of oocyte IRS1 and a correction of cumulus cell IGF1 expression. The present study demonstrates that in a physiological glucose concentration, leptin plays a negligible role in oocyte function. However, leptin appears to modulate the deleterious impact of a high glucose environment on oocyte function. Mol. Reprod. Dev. 79: 296–307, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2047246164 created "2016-06-24" @default.
• W2047246164 creator A5020430947 @default.
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• W2047246164 date "2012-02-24" @default.
• W2047246164 modified "2023-09-23" @default.
• W2047246164 title "The effect of leptin on maturing porcine oocytes is dependent on glucose concentration" @default.
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• W2047246164 doi "https://doi.org/10.1002/mrd.22029" @default.
• W2047246164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22368147" @default.
• W2047246164 hasPublicationYear "2012" @default.
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