Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047257800> ?p ?o ?g. }
- W2047257800 endingPage "S112" @default.
- W2047257800 startingPage "S99" @default.
- W2047257800 abstract "Nonalcoholic steatohepatitis (NASH), the lynchpin between steatosis and cirrhosis in the spectrum of nonalcoholic fatty liver disorders (NAFLD), was barely recognized in 1981. NAFLD is now present in 17% to 33% of Americans, has a worldwide distribution, and parallels the frequency of central adiposity, obesity, insulin resistance, metabolic syndrome and type 2 diabetes. NASH could be present in one third of NAFLD cases. Age, activity of steatohepatitis, and established fibrosis predispose to cirrhosis, which has a 7- to 10-year liver-related mortality of 12% to 25%. Many cases of cryptogenic cirrhosis are likely endstage NASH. While endstage NAFLD currently accounts for 4% to 10% of liver transplants, this may soon rise. Pathogenic concepts for NAFLD/NASH must account for the strong links with overnutrition and underactivity, insulin resistance, and genetic factors. Lipotoxicity, oxidative stress, cytokines, and other proinflammatory mediators may each play a role in transition of steatosis to NASH. The present “gold standard” management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity. Whether achieved by “lifestyle adjustment” or anti-obesity surgery, this improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis. The same potential for “unwinding” fibrotic NASH is indicated by studies of the peroxisome proliferation activator receptor (PPAR) - γ agonist “glitazones,” but these agents may improve liver disease at the expense of worsening obesity. Future challenges are to approach NAFLD as a preventive public health initiative and to motivate affected persons to adopt a healthier lifestyle. (Hepatology 2006;43:S99-S112.)" @default.
- W2047257800 created "2016-06-24" @default.
- W2047257800 creator A5017524854 @default.
- W2047257800 creator A5074255400 @default.
- W2047257800 date "2006-02-01" @default.
- W2047257800 modified "2023-10-16" @default.
- W2047257800 title "Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis" @default.
- W2047257800 cites W124629821 @default.
- W2047257800 cites W1252504093 @default.
- W2047257800 cites W1514796040 @default.
- W2047257800 cites W1534360145 @default.
- W2047257800 cites W1651866740 @default.
- W2047257800 cites W1965019476 @default.
- W2047257800 cites W1968396962 @default.
- W2047257800 cites W1970135355 @default.
- W2047257800 cites W1973573989 @default.
- W2047257800 cites W1973842058 @default.
- W2047257800 cites W1975716130 @default.
- W2047257800 cites W1976173209 @default.
- W2047257800 cites W1977036235 @default.
- W2047257800 cites W1977875107 @default.
- W2047257800 cites W1980843282 @default.
- W2047257800 cites W1982254200 @default.
- W2047257800 cites W1982578021 @default.
- W2047257800 cites W1983181715 @default.
- W2047257800 cites W1983417944 @default.
- W2047257800 cites W1985592156 @default.
- W2047257800 cites W1986252060 @default.
- W2047257800 cites W1986323764 @default.
- W2047257800 cites W1988634547 @default.
- W2047257800 cites W1988845519 @default.
- W2047257800 cites W1994194872 @default.
- W2047257800 cites W1995000970 @default.
- W2047257800 cites W1995612841 @default.
- W2047257800 cites W1996559225 @default.
- W2047257800 cites W1998352351 @default.
- W2047257800 cites W1999426013 @default.
- W2047257800 cites W2001671445 @default.
- W2047257800 cites W2001837599 @default.
- W2047257800 cites W2002729632 @default.
- W2047257800 cites W2003403665 @default.
- W2047257800 cites W2007516026 @default.
- W2047257800 cites W2008162733 @default.
- W2047257800 cites W2010746044 @default.
- W2047257800 cites W2012295774 @default.
- W2047257800 cites W2013081324 @default.
- W2047257800 cites W2015000433 @default.
- W2047257800 cites W2016199234 @default.
- W2047257800 cites W2017554448 @default.
- W2047257800 cites W2021136932 @default.
- W2047257800 cites W2024314098 @default.
- W2047257800 cites W2025160818 @default.
- W2047257800 cites W2025946383 @default.
- W2047257800 cites W2027670788 @default.
- W2047257800 cites W2029811522 @default.
- W2047257800 cites W2031481479 @default.
- W2047257800 cites W2033417635 @default.
- W2047257800 cites W2033630237 @default.
- W2047257800 cites W2033829190 @default.
- W2047257800 cites W2034689989 @default.
- W2047257800 cites W2039800528 @default.
- W2047257800 cites W2040109162 @default.
- W2047257800 cites W2042555983 @default.
- W2047257800 cites W2045182106 @default.
- W2047257800 cites W2045911846 @default.
- W2047257800 cites W2046360039 @default.
- W2047257800 cites W2046719161 @default.
- W2047257800 cites W2048571130 @default.
- W2047257800 cites W2049881486 @default.
- W2047257800 cites W2050385934 @default.
- W2047257800 cites W2051987387 @default.
- W2047257800 cites W2052006680 @default.
- W2047257800 cites W2055518919 @default.
- W2047257800 cites W2056333393 @default.
- W2047257800 cites W2058709707 @default.
- W2047257800 cites W2060431825 @default.
- W2047257800 cites W2062663604 @default.
- W2047257800 cites W2063671857 @default.
- W2047257800 cites W2065788317 @default.
- W2047257800 cites W2067740038 @default.
- W2047257800 cites W2069103752 @default.
- W2047257800 cites W2070680921 @default.
- W2047257800 cites W2071362602 @default.
- W2047257800 cites W2071875898 @default.
- W2047257800 cites W2071966563 @default.
- W2047257800 cites W2075060360 @default.
- W2047257800 cites W2076204761 @default.
- W2047257800 cites W2076858432 @default.
- W2047257800 cites W2080348345 @default.
- W2047257800 cites W2080361134 @default.
- W2047257800 cites W2082185635 @default.
- W2047257800 cites W2082299629 @default.
- W2047257800 cites W2082509181 @default.
- W2047257800 cites W2083999496 @default.
- W2047257800 cites W2085336832 @default.
- W2047257800 cites W2087265885 @default.
- W2047257800 cites W2087829753 @default.
- W2047257800 cites W2088849513 @default.