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• W2047262829 endingPage "153" @default.
• W2047262829 startingPage "153" @default.
• W2047262829 abstract "A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. Once TLRs are activated, they lead to the expression of hundreds of genes together and bridge the arm of innate and adaptive immune responses. We characterized the gene expression profile of Toll-like receptor 4 (TLR4) in RAW 264.7 cells when it bound with its ligand, 2-keto-3-deoxyoctonate (KDO), the active part of lipopolysaccharide. In addition, to determine the network communications among the TLR, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and GPCR, we tested RAW 264.7 cells with KDO, interferon-β, or cAMP analog 8-Br. The ligands were also administered as a pair of double and triple combinations. Keywords: gene expression, G-protein coupled receptors, immune responses, innate immunity, macrophages, Toll-like receptors" @default.
• W2047262829 created "2016-06-24" @default.
• W2047262829 creator A5020674417 @default.
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• W2047262829 date "2012-01-01" @default.
• W2047262829 modified "2023-10-01" @default.
• W2047262829 title "Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling" @default.
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• W2047262829 doi "https://doi.org/10.5808/gi.2012.10.3.153" @default.
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