Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047265534> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2047265534 endingPage "546" @default.
- W2047265534 startingPage "537" @default.
- W2047265534 abstract "Dopamine D1-D5 receptor protein immunoreactivity and tyrosine hydroxylase (TH) immunoreactivity were investigated on the mesenteric arterial tree by immunohistochemistry. The density of various dopamine receptors and TH immunoreactivity was compared between young (6-month-old), adult (15-month-old) and senescent (24-month-old) Fischer 344 rats by computer-assisted microdensitometry. The dopamine D1-like (D1 and D5) receptors were localized on the tunica media of different sized mesenteric artery branches. The D2-like (D2, D3 and D4) receptors as well as TH immunoreactivity were localized only on the adventitia-media transitional zone of mesenteric arterial tree. Expression of the D1 and D5 receptors was decreased in both adult and senescent rats compared to the young rats, suggesting an age-related decline in these receptors. Of the D2-like receptors, the expression of the D2 receptor was decreased as a function of age, while the D3 receptor was unchanged in the senescent rats compared to the young rats. Expression of the D4 receptor was increased in adult, but was unchanged in the senescent rats compared to young animals. TH immunoreactivity was increased as a function of age. The above data suggest that reduction in the D1, D2 and D5 receptor expression may contribute to the deficiency in the dopamine-mediated vasorelaxation and hence blood flow in the mesenteric vascular tree in aging. The different sensitivity to aging of sympathetic neuroeffector junctions labeled by TH and of dopamine D2-like receptors that are known to be prejunctional, suggests that age-related changes of dopamine receptor expression in the mesenteric vasculature reflect more complicated mechanisms than simple up- or down-regulation phenomena." @default.
- W2047265534 created "2016-06-24" @default.
- W2047265534 creator A5007869905 @default.
- W2047265534 creator A5023330375 @default.
- W2047265534 creator A5060302919 @default.
- W2047265534 creator A5074048254 @default.
- W2047265534 creator A5078593627 @default.
- W2047265534 creator A5085220617 @default.
- W2047265534 date "2002-03-01" @default.
- W2047265534 modified "2023-09-30" @default.
- W2047265534 title "Age-related changes of dopamine receptor protein immunoreactivity in the rat mesenteric vascular tree" @default.
- W2047265534 cites W1500704870 @default.
- W2047265534 cites W1979431840 @default.
- W2047265534 cites W1981446549 @default.
- W2047265534 cites W2006080533 @default.
- W2047265534 cites W2016666929 @default.
- W2047265534 cites W2028284696 @default.
- W2047265534 cites W2028702193 @default.
- W2047265534 cites W2035173398 @default.
- W2047265534 cites W2049708419 @default.
- W2047265534 cites W2056574787 @default.
- W2047265534 cites W2058638976 @default.
- W2047265534 cites W2059134960 @default.
- W2047265534 cites W2065579225 @default.
- W2047265534 cites W2087688448 @default.
- W2047265534 cites W2090136511 @default.
- W2047265534 cites W2091770433 @default.
- W2047265534 cites W2100659128 @default.
- W2047265534 cites W2102541501 @default.
- W2047265534 cites W2113557949 @default.
- W2047265534 cites W2142690926 @default.
- W2047265534 cites W2398237628 @default.
- W2047265534 doi "https://doi.org/10.1016/s0047-6374(01)00361-x" @default.
- W2047265534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11796139" @default.
- W2047265534 hasPublicationYear "2002" @default.
- W2047265534 type Work @default.
- W2047265534 sameAs 2047265534 @default.
- W2047265534 citedByCount "11" @default.
- W2047265534 countsByYear W20472655342012 @default.
- W2047265534 countsByYear W20472655342014 @default.
- W2047265534 countsByYear W20472655342015 @default.
- W2047265534 countsByYear W20472655342019 @default.
- W2047265534 countsByYear W20472655342021 @default.
- W2047265534 crossrefType "journal-article" @default.
- W2047265534 hasAuthorship W2047265534A5007869905 @default.
- W2047265534 hasAuthorship W2047265534A5023330375 @default.
- W2047265534 hasAuthorship W2047265534A5060302919 @default.
- W2047265534 hasAuthorship W2047265534A5074048254 @default.
- W2047265534 hasAuthorship W2047265534A5078593627 @default.
- W2047265534 hasAuthorship W2047265534A5085220617 @default.
- W2047265534 hasConcept C120069818 @default.
- W2047265534 hasConcept C120750228 @default.
- W2047265534 hasConcept C126322002 @default.
- W2047265534 hasConcept C134018914 @default.
- W2047265534 hasConcept C141961939 @default.
- W2047265534 hasConcept C170493617 @default.
- W2047265534 hasConcept C2993002077 @default.
- W2047265534 hasConcept C44208683 @default.
- W2047265534 hasConcept C513476851 @default.
- W2047265534 hasConcept C71924100 @default.
- W2047265534 hasConcept C86803240 @default.
- W2047265534 hasConceptScore W2047265534C120069818 @default.
- W2047265534 hasConceptScore W2047265534C120750228 @default.
- W2047265534 hasConceptScore W2047265534C126322002 @default.
- W2047265534 hasConceptScore W2047265534C134018914 @default.
- W2047265534 hasConceptScore W2047265534C141961939 @default.
- W2047265534 hasConceptScore W2047265534C170493617 @default.
- W2047265534 hasConceptScore W2047265534C2993002077 @default.
- W2047265534 hasConceptScore W2047265534C44208683 @default.
- W2047265534 hasConceptScore W2047265534C513476851 @default.
- W2047265534 hasConceptScore W2047265534C71924100 @default.
- W2047265534 hasConceptScore W2047265534C86803240 @default.
- W2047265534 hasIssue "5" @default.
- W2047265534 hasLocation W20472655341 @default.
- W2047265534 hasLocation W20472655342 @default.
- W2047265534 hasOpenAccess W2047265534 @default.
- W2047265534 hasPrimaryLocation W20472655341 @default.
- W2047265534 hasRelatedWork W1963851142 @default.
- W2047265534 hasRelatedWork W2005318526 @default.
- W2047265534 hasRelatedWork W2019708552 @default.
- W2047265534 hasRelatedWork W2030683825 @default.
- W2047265534 hasRelatedWork W2034014095 @default.
- W2047265534 hasRelatedWork W2083097367 @default.
- W2047265534 hasRelatedWork W2168345297 @default.
- W2047265534 hasRelatedWork W2334162436 @default.
- W2047265534 hasRelatedWork W2411875046 @default.
- W2047265534 hasRelatedWork W2418020465 @default.
- W2047265534 hasVolume "123" @default.
- W2047265534 isParatext "false" @default.
- W2047265534 isRetracted "false" @default.
- W2047265534 magId "2047265534" @default.
- W2047265534 workType "article" @default.