Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047268479> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2047268479 endingPage "1672" @default.
- W2047268479 startingPage "1667" @default.
- W2047268479 abstract "Treatment with cetuximab is accompanied by the development of an acneiform follicular skin exanthema in more than 80 % of patients. Severe exanthema (grade III/IV) develops in about 9–19 % of patients with the necessity of cetuximab dose reduction or cessation. The study presented was a retrospective analysis of 50 gastrointestinal cancer patients treated with cetuximab in combination with either FOLFIRI or FOLFOX. One cohort of 15 patients received an in-house reactive skin protocol upon development of an exanthema. A second cohort of 15 patients received a skin prophylaxis starting with the first dose of cetuximab before clinical signs of toxicity. A third historic group of 20 patients had received no skin prophylaxis or reactive treatment. 19/20 patients of the historic group developed a skin exanthema. Grade III/IV exanthema was observed six times. Forty percent discontinued cetuximab therapy. The average time to exanthema onset was 14.7 days. Applying the reactive skin protocol after the first occurrence of an exanthema, the exanthema was downgraded as follows: No patients developed grade IV° exanthema, and two patients developed a grade II/III exanthema. In the majority of cases, the reactive skin protocol controlled the exanthema (grade 0–I°). No dose reductions in cetuximab were necessary. Applying the prophylactic skin protocol starting at the beginning of cetuximab application was not superior to the reactive skin protocol. Cetuximab-induced skin exanthema can be coped with a reactive protocol equally effective as compared to a prophylactic skin treatment. A prospective study with higher patient numbers is planned." @default.
- W2047268479 created "2016-06-24" @default.
- W2047268479 creator A5005303780 @default.
- W2047268479 creator A5009529288 @default.
- W2047268479 creator A5011887107 @default.
- W2047268479 creator A5019128403 @default.
- W2047268479 creator A5022970757 @default.
- W2047268479 creator A5040589443 @default.
- W2047268479 creator A5045367911 @default.
- W2047268479 creator A5048426715 @default.
- W2047268479 creator A5067876841 @default.
- W2047268479 creator A5080071751 @default.
- W2047268479 date "2013-08-07" @default.
- W2047268479 modified "2023-10-01" @default.
- W2047268479 title "Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective" @default.
- W2047268479 cites W1975426795 @default.
- W2047268479 cites W1978771384 @default.
- W2047268479 cites W1983751091 @default.
- W2047268479 cites W2037791152 @default.
- W2047268479 cites W2052557399 @default.
- W2047268479 cites W2058992264 @default.
- W2047268479 cites W2067595452 @default.
- W2047268479 cites W2100842180 @default.
- W2047268479 cites W2147513363 @default.
- W2047268479 cites W2160344439 @default.
- W2047268479 cites W2168377135 @default.
- W2047268479 cites W2322300598 @default.
- W2047268479 doi "https://doi.org/10.1007/s00432-013-1483-4" @default.
- W2047268479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3771414" @default.
- W2047268479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23918349" @default.
- W2047268479 hasPublicationYear "2013" @default.
- W2047268479 type Work @default.
- W2047268479 sameAs 2047268479 @default.
- W2047268479 citedByCount "21" @default.
- W2047268479 countsByYear W20472684792014 @default.
- W2047268479 countsByYear W20472684792015 @default.
- W2047268479 countsByYear W20472684792016 @default.
- W2047268479 countsByYear W20472684792017 @default.
- W2047268479 countsByYear W20472684792018 @default.
- W2047268479 countsByYear W20472684792019 @default.
- W2047268479 countsByYear W20472684792020 @default.
- W2047268479 countsByYear W20472684792021 @default.
- W2047268479 countsByYear W20472684792022 @default.
- W2047268479 crossrefType "journal-article" @default.
- W2047268479 hasAuthorship W2047268479A5005303780 @default.
- W2047268479 hasAuthorship W2047268479A5009529288 @default.
- W2047268479 hasAuthorship W2047268479A5011887107 @default.
- W2047268479 hasAuthorship W2047268479A5019128403 @default.
- W2047268479 hasAuthorship W2047268479A5022970757 @default.
- W2047268479 hasAuthorship W2047268479A5040589443 @default.
- W2047268479 hasAuthorship W2047268479A5045367911 @default.
- W2047268479 hasAuthorship W2047268479A5048426715 @default.
- W2047268479 hasAuthorship W2047268479A5067876841 @default.
- W2047268479 hasAuthorship W2047268479A5080071751 @default.
- W2047268479 hasBestOaLocation W20472684791 @default.
- W2047268479 hasConcept C121608353 @default.
- W2047268479 hasConcept C126322002 @default.
- W2047268479 hasConcept C141071460 @default.
- W2047268479 hasConcept C16005928 @default.
- W2047268479 hasConcept C2779998722 @default.
- W2047268479 hasConcept C526805850 @default.
- W2047268479 hasConcept C71924100 @default.
- W2047268479 hasConceptScore W2047268479C121608353 @default.
- W2047268479 hasConceptScore W2047268479C126322002 @default.
- W2047268479 hasConceptScore W2047268479C141071460 @default.
- W2047268479 hasConceptScore W2047268479C16005928 @default.
- W2047268479 hasConceptScore W2047268479C2779998722 @default.
- W2047268479 hasConceptScore W2047268479C526805850 @default.
- W2047268479 hasConceptScore W2047268479C71924100 @default.
- W2047268479 hasIssue "10" @default.
- W2047268479 hasLocation W20472684791 @default.
- W2047268479 hasLocation W20472684792 @default.
- W2047268479 hasLocation W20472684793 @default.
- W2047268479 hasLocation W20472684794 @default.
- W2047268479 hasOpenAccess W2047268479 @default.
- W2047268479 hasPrimaryLocation W20472684791 @default.
- W2047268479 hasRelatedWork W2002120878 @default.
- W2047268479 hasRelatedWork W2003938723 @default.
- W2047268479 hasRelatedWork W2047041949 @default.
- W2047268479 hasRelatedWork W2047967234 @default.
- W2047268479 hasRelatedWork W2320234166 @default.
- W2047268479 hasRelatedWork W2327974592 @default.
- W2047268479 hasRelatedWork W2389026000 @default.
- W2047268479 hasRelatedWork W2439875401 @default.
- W2047268479 hasRelatedWork W2999047802 @default.
- W2047268479 hasRelatedWork W4361951297 @default.
- W2047268479 hasVolume "139" @default.
- W2047268479 isParatext "false" @default.
- W2047268479 isRetracted "false" @default.
- W2047268479 magId "2047268479" @default.
- W2047268479 workType "article" @default.