Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047275938> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2047275938 endingPage "300" @default.
- W2047275938 startingPage "291" @default.
- W2047275938 abstract "L-[3H]Glutamate, D-[3H]aspartate, DL-[3H]2-amino-5-phosphonovalerate (AP5) and [3H]N-methyl-D-aspartate (NMDA) were evaluated as radioligands using postsynaptic density (PSD) preparations from rat brain. L[3H]Glutamate had the highest affinity and greatest percentage specific binding, followed by D-[3H]aspartate > DL-[3H]AP5 > [3H]NMDA. The pharmacological specificity of the binding of each radioligand indicated an interaction with NMDA-preferring receptors, the order of potency of displacing compounds tested being L-glutamate > D-aspartate > D-AP5 > DL-AP5 > ibotenate > NMDLA > quisqualate. For L-[3H]glutamate the data revealed an interaction with two sites, the major one having NMDA receptor characteristics and the major one resembling the quisqualate-preferring receptor. Against L-[3H]glutamate binding, quisqualate showed a two-component inhibition profile with an affinity of 25 μM at the NMDA site and 0.19 μM at the quisqualate site. Thus, by using several radioligands possesding activity at NMDA receptors, we confirm that an NMDA receptor binding site is present in crude PSDs. Although it is less selective than D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA, L-[3H]glutamate remains, by virtue of its high affinity, the ligand of choice for the study of NMDA receptors in preparations where such sites predominate." @default.
- W2047275938 created "2016-06-24" @default.
- W2047275938 creator A5056598194 @default.
- W2047275938 creator A5060278370 @default.
- W2047275938 date "1987-01-01" @default.
- W2047275938 modified "2023-09-23" @default.
- W2047275938 title "Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain" @default.
- W2047275938 cites W1567544633 @default.
- W2047275938 cites W1775749144 @default.
- W2047275938 cites W1963993420 @default.
- W2047275938 cites W1966621949 @default.
- W2047275938 cites W1966751481 @default.
- W2047275938 cites W1970377013 @default.
- W2047275938 cites W1970393142 @default.
- W2047275938 cites W1975317646 @default.
- W2047275938 cites W1985053181 @default.
- W2047275938 cites W1997568797 @default.
- W2047275938 cites W1998164097 @default.
- W2047275938 cites W2011999599 @default.
- W2047275938 cites W2025801062 @default.
- W2047275938 cites W2026389045 @default.
- W2047275938 cites W2026767130 @default.
- W2047275938 cites W2033436953 @default.
- W2047275938 cites W2042002480 @default.
- W2047275938 cites W2050886880 @default.
- W2047275938 cites W2054683291 @default.
- W2047275938 cites W2058148599 @default.
- W2047275938 cites W2061532372 @default.
- W2047275938 cites W2061718284 @default.
- W2047275938 cites W2066168019 @default.
- W2047275938 cites W2069499214 @default.
- W2047275938 cites W2074283531 @default.
- W2047275938 cites W2082810336 @default.
- W2047275938 cites W2085169192 @default.
- W2047275938 cites W2087105450 @default.
- W2047275938 cites W2094906883 @default.
- W2047275938 cites W2148343974 @default.
- W2047275938 cites W2180941170 @default.
- W2047275938 doi "https://doi.org/10.1016/0014-2999(87)90025-2" @default.
- W2047275938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2881792" @default.
- W2047275938 hasPublicationYear "1987" @default.
- W2047275938 type Work @default.
- W2047275938 sameAs 2047275938 @default.
- W2047275938 citedByCount "109" @default.
- W2047275938 countsByYear W20472759382012 @default.
- W2047275938 countsByYear W20472759382014 @default.
- W2047275938 countsByYear W20472759382015 @default.
- W2047275938 countsByYear W20472759382016 @default.
- W2047275938 countsByYear W20472759382018 @default.
- W2047275938 crossrefType "journal-article" @default.
- W2047275938 hasAuthorship W2047275938A5056598194 @default.
- W2047275938 hasAuthorship W2047275938A5060278370 @default.
- W2047275938 hasConcept C12554922 @default.
- W2047275938 hasConcept C160268369 @default.
- W2047275938 hasConcept C169760540 @default.
- W2047275938 hasConcept C170493617 @default.
- W2047275938 hasConcept C185592680 @default.
- W2047275938 hasConcept C197341189 @default.
- W2047275938 hasConcept C2779484449 @default.
- W2047275938 hasConcept C55493867 @default.
- W2047275938 hasConcept C61174792 @default.
- W2047275938 hasConcept C67018056 @default.
- W2047275938 hasConcept C71240020 @default.
- W2047275938 hasConcept C73009533 @default.
- W2047275938 hasConcept C86803240 @default.
- W2047275938 hasConceptScore W2047275938C12554922 @default.
- W2047275938 hasConceptScore W2047275938C160268369 @default.
- W2047275938 hasConceptScore W2047275938C169760540 @default.
- W2047275938 hasConceptScore W2047275938C170493617 @default.
- W2047275938 hasConceptScore W2047275938C185592680 @default.
- W2047275938 hasConceptScore W2047275938C197341189 @default.
- W2047275938 hasConceptScore W2047275938C2779484449 @default.
- W2047275938 hasConceptScore W2047275938C55493867 @default.
- W2047275938 hasConceptScore W2047275938C61174792 @default.
- W2047275938 hasConceptScore W2047275938C67018056 @default.
- W2047275938 hasConceptScore W2047275938C71240020 @default.
- W2047275938 hasConceptScore W2047275938C73009533 @default.
- W2047275938 hasConceptScore W2047275938C86803240 @default.
- W2047275938 hasIssue "3" @default.
- W2047275938 hasLocation W20472759381 @default.
- W2047275938 hasLocation W20472759382 @default.
- W2047275938 hasOpenAccess W2047275938 @default.
- W2047275938 hasPrimaryLocation W20472759381 @default.
- W2047275938 hasRelatedWork W1502257144 @default.
- W2047275938 hasRelatedWork W1654786425 @default.
- W2047275938 hasRelatedWork W1972788353 @default.
- W2047275938 hasRelatedWork W1972829230 @default.
- W2047275938 hasRelatedWork W2025676835 @default.
- W2047275938 hasRelatedWork W2038917760 @default.
- W2047275938 hasRelatedWork W2126425076 @default.
- W2047275938 hasRelatedWork W2396204292 @default.
- W2047275938 hasRelatedWork W2401653406 @default.
- W2047275938 hasRelatedWork W2316593469 @default.
- W2047275938 hasVolume "133" @default.
- W2047275938 isParatext "false" @default.
- W2047275938 isRetracted "false" @default.
- W2047275938 magId "2047275938" @default.
- W2047275938 workType "article" @default.