Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047289065> ?p ?o ?g. }
- W2047289065 abstract "Roughly speaking, restitution is the dependence of recovery time of cardiac electrical activity on heart rate. Increased restitution slope is theorized to be predictive of sudden death after heart injury such as from coronary artery occlusion (ischemia). Adrenaline analogs are known to increase restitution slope in normal hearts, but their effects in failing hearts are unknown. Twenty-six rabbits underwent coronary ligation (n = 15) or sham surgery (n = 11) and implantation of a lead in the heart for recording electrocardiograms. Eight weeks later, unanesthetized rabbits were given 0.25-2.0 ml of 1 μmol/L isoprenaline intravenously, which increased heart rate. Heart rate was quantified by time between QRS peaks (RR) and heart activity duration by R to T peak time (QTp). Ligated rabbits (n = 6) had lower ejection fraction than sham rabbits (n = 7, p < 0.0001) indicative of heart failure, but similar baseline RR (269 ± 15 vs 292 ± 23 ms, p = 0.07), QTp (104 ± 17 vs 91 ± 9 ms, p = 0.1), and isoprenaline-induced minimum RR (204 ± 11 vs 208 ± 6 ms, p = 0.4). The trajectory of QTp vs TQ plots displayed hysteresis and regions of negative slope. The slope of the positive slope region was >1 in ligated rabbits (1.27 ± 0.66) and <1 in sham rabbits (0.35 ± 0.14, p = 0.004). The absolute value of the negative slope was greater in ligated rabbits (- 0.81 ± 0.52 vs - 0.35 ± 0.14, p = 0.04). Isoprenaline increased heart rate and slopes of restitution trajectory in failing hearts. The dynamics of restitution trajectory may hold clues for sudden death in heart failure patients." @default.
- W2047289065 created "2016-06-24" @default.
- W2047289065 creator A5006766033 @default.
- W2047289065 creator A5010037994 @default.
- W2047289065 creator A5032088144 @default.
- W2047289065 creator A5035166532 @default.
- W2047289065 creator A5084256462 @default.
- W2047289065 creator A5088079919 @default.
- W2047289065 date "2010-01-15" @default.
- W2047289065 modified "2023-09-24" @default.
- W2047289065 title "Isoprenaline increases the slopes of restitution trajectory in the conscious rabbit with ischemic heart failure" @default.
- W2047289065 cites W1820800243 @default.
- W2047289065 cites W1931655495 @default.
- W2047289065 cites W1965987399 @default.
- W2047289065 cites W1970677226 @default.
- W2047289065 cites W1979134042 @default.
- W2047289065 cites W1986061022 @default.
- W2047289065 cites W1989532407 @default.
- W2047289065 cites W1993457540 @default.
- W2047289065 cites W1995188078 @default.
- W2047289065 cites W1997535715 @default.
- W2047289065 cites W1999038146 @default.
- W2047289065 cites W2011750133 @default.
- W2047289065 cites W2017095658 @default.
- W2047289065 cites W2020597362 @default.
- W2047289065 cites W2024901942 @default.
- W2047289065 cites W2025792572 @default.
- W2047289065 cites W2029388013 @default.
- W2047289065 cites W2031013072 @default.
- W2047289065 cites W2034214746 @default.
- W2047289065 cites W2037462241 @default.
- W2047289065 cites W2040990447 @default.
- W2047289065 cites W2054905500 @default.
- W2047289065 cites W2056620215 @default.
- W2047289065 cites W2062017475 @default.
- W2047289065 cites W2065776520 @default.
- W2047289065 cites W2075725684 @default.
- W2047289065 cites W2081231690 @default.
- W2047289065 cites W2088339331 @default.
- W2047289065 cites W2093193183 @default.
- W2047289065 cites W2095232367 @default.
- W2047289065 cites W2104844745 @default.
- W2047289065 cites W2110273055 @default.
- W2047289065 cites W2123181530 @default.
- W2047289065 cites W2134165884 @default.
- W2047289065 cites W2135454160 @default.
- W2047289065 cites W2139510409 @default.
- W2047289065 cites W2142100237 @default.
- W2047289065 cites W2150695836 @default.
- W2047289065 cites W2153805504 @default.
- W2047289065 cites W2153855760 @default.
- W2047289065 cites W2156259505 @default.
- W2047289065 cites W2157174926 @default.
- W2047289065 cites W2158611746 @default.
- W2047289065 cites W2325116796 @default.
- W2047289065 cites W2414145854 @default.
- W2047289065 cites W2425662256 @default.
- W2047289065 doi "https://doi.org/10.1007/s10867-009-9185-5" @default.
- W2047289065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2868975" @default.
- W2047289065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21629591" @default.
- W2047289065 hasPublicationYear "2010" @default.
- W2047289065 type Work @default.
- W2047289065 sameAs 2047289065 @default.
- W2047289065 citedByCount "2" @default.
- W2047289065 countsByYear W20472890652012 @default.
- W2047289065 countsByYear W20472890652018 @default.
- W2047289065 crossrefType "journal-article" @default.
- W2047289065 hasAuthorship W2047289065A5006766033 @default.
- W2047289065 hasAuthorship W2047289065A5010037994 @default.
- W2047289065 hasAuthorship W2047289065A5032088144 @default.
- W2047289065 hasAuthorship W2047289065A5035166532 @default.
- W2047289065 hasAuthorship W2047289065A5084256462 @default.
- W2047289065 hasAuthorship W2047289065A5088079919 @default.
- W2047289065 hasBestOaLocation W20472890652 @default.
- W2047289065 hasConcept C126322002 @default.
- W2047289065 hasConcept C164705383 @default.
- W2047289065 hasConcept C17744445 @default.
- W2047289065 hasConcept C179437574 @default.
- W2047289065 hasConcept C199539241 @default.
- W2047289065 hasConcept C24998067 @default.
- W2047289065 hasConcept C2776090920 @default.
- W2047289065 hasConcept C2777720157 @default.
- W2047289065 hasConcept C2777953023 @default.
- W2047289065 hasConcept C2778198053 @default.
- W2047289065 hasConcept C2778392301 @default.
- W2047289065 hasConcept C42219234 @default.
- W2047289065 hasConcept C71924100 @default.
- W2047289065 hasConcept C78085059 @default.
- W2047289065 hasConcept C84393581 @default.
- W2047289065 hasConceptScore W2047289065C126322002 @default.
- W2047289065 hasConceptScore W2047289065C164705383 @default.
- W2047289065 hasConceptScore W2047289065C17744445 @default.
- W2047289065 hasConceptScore W2047289065C179437574 @default.
- W2047289065 hasConceptScore W2047289065C199539241 @default.
- W2047289065 hasConceptScore W2047289065C24998067 @default.
- W2047289065 hasConceptScore W2047289065C2776090920 @default.
- W2047289065 hasConceptScore W2047289065C2777720157 @default.
- W2047289065 hasConceptScore W2047289065C2777953023 @default.
- W2047289065 hasConceptScore W2047289065C2778198053 @default.
- W2047289065 hasConceptScore W2047289065C2778392301 @default.