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- W2047311909 abstract "The present study investigated the effects of interleukin-1β (IL-1β) injected intrathecally (i.t.) on carrageenan-induced thermal hyperalgesia and spinal c-Fos expression. The paw withdrawal latency (PWL) by the thermal stimulus was taken as an index of the thermal hyperalgesia of rats. I.t. injection of 10 ng IL-1β significantly increased the PWL of the carrageenan-injected paw. Expression of c-Fos induced by intraplantar (i.pl.) injection of carrageenan was examined in the spinal cord with immunohistochemical methods. Three hours after i.pl. injection of carrageenan, the number of c-Fos-like immunoreactive (c-Fos-LI) neurons was significantly increased in laminae I–II, III–IV and V–VI of the ipsilateral spinal cord at L4–5 with the higher density in laminae I–II and V–VI. I.t. pre-injected IL-1β significantly decreased the number of carrageenan-induced c-Fos-LI neurons in laminae I–II in the ipsilateral spinal cord and also inhibited the hyperalgesia induced by i.pl. carrageenan. These results suggested that i.t. injection of IL-1β suppressed the central nociceptive input into laminae I–II and produced an antinociceptive effect." @default.
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- W2047311909 date "2002-08-01" @default.
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- W2047311909 title "Inhibitory effects of intrathecally administered interleukin-1β on carrageenan-induced hyperalgesia and spinal c-Fos expression in rats" @default.
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- W2047311909 doi "https://doi.org/10.1016/s0304-3940(02)00515-3" @default.
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