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- W2047320705 abstract "Endometrial epithelial atypias which precede the development of adenocarcinoma have been observed in endometria examined prior to the development of carcinoma, concommitantly in the endometrium of patients who elsewhere in the same specimen have areas of adenocarcinoma, and in some instances in actual transition from foci of such atypias to adenocarcinomas. The atypias can be categorized histologically as adenomatous hyperplasia, atypical hyperplasia, and carcinoma in situ. Cystic hyperplasia and adenomatous polyp in some instances appear to antedate these precursor lesions. They are observed in about 10% of endometrial curettage specimens in a general hospital. They must be differentiated from other lesions not known to be precursors of carcinoma, including intraglandular morules, squamous metaplasia, tubal metaplasia, and cystic atrophy. The frequency of these lesions progressing to carcinoma has not been determined but has been estimated to be 10%. That these lesions are all reversible when normal menstrual cycles are established or by the use of progesterone or progestational agents is established." @default.
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- W2047320705 date "1974-08-01" @default.
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- W2047320705 title "Endometrial hyperplasia and carcinoma in-situ" @default.
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- W2047320705 doi "https://doi.org/10.1016/0090-8258(74)90006-7" @default.
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