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- W2047324014 abstract "Abstract: HLA-DR specifities in 72 Addison's (AD) patients and 808 local controls were compared. We confirmed earlier reports that the HLA-DR3 specificity is significantly increased in AD patients. In our study a relative risk of 3.4 X2= 22.5; pc= 0.01) for the disease was calculated. Analysis of HLA-DQB1 alleles in DR4+ Addison's patients with diabetes mellitus (N = 6) and without IDDM (14 of 18 individuals tested) revealed that the HLA-DQw8 allele (DQB1*0302) was significantly increased in AD patients with IDDM (x2= 13.5; p=0.001); conversely, a clustering of the HLA-DQw7 allele was detected in DR4+ Addison's patients without IDDM. We thus conclude that particular polymorphic alleles corresponding to non-charged amino acids at position 57 of the HLA-DQ β-chain [non-Asp-57 alleles] are associated with IDDM also in Addison's patients." @default.
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- W2047324014 date "1991-03-01" @default.
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- W2047324014 title "The HLA-DQβ non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease" @default.
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- W2047324014 doi "https://doi.org/10.1111/j.1399-0039.1991.tb01858.x" @default.
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