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- W2047332337 abstract "Publisher Summary This chapter elaborates the metabolites of catecholamines in the cerebrospinal fluid. Several substances having the vanyl group in their structure will give rise to a similar fluorescence. Among these vanyllactic acid must be considered because it is found in the urine of patients treated with l -3, 4-dihydroxyphenylalanine and would be extracted, if present in the cerebrospinal fluid of such patients. It is found that when other phenolic acids including7-hydroxyphenylacetic acid yields less than 2% of the fluorescence seen when homovanillic acid (HVA) is treated. An isomer of HVA, 3-hydroxy-4-methoxyphenylacetic acid has been demonstrated to be present in cerebrospinal fluid, a finding which may have far reaching implications. For the fluorimetric assay of HVA, it is shown that the fluorimetric assay of HVA in cerebrospinal fluid gives results which are comparable with the values obtained by their colorimetric procedure after separation of the two isomers. It is observed that 3,4-dihydroxyphenylacetic acid (DOPAC) was present in extracts of dog cerebrospinal fluid and used the fluorescence which is developed when DOPAC is condensed with 1,2-diaminoethane to estimate its concentration." @default.
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- W2047332337 date "1973-01-01" @default.
- W2047332337 modified "2023-10-16" @default.
- W2047332337 title "METABOLITES OF CATECHOLAMINES IN THE CEREBROSPINAL FLUID" @default.
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- W2047332337 doi "https://doi.org/10.1016/b978-0-08-017922-3.50202-1" @default.
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