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• W2047337895 endingPage "773" @default.
• W2047337895 startingPage "758" @default.
• W2047337895 abstract "ABSTRACT The fission yeast minichromosome loss mutant mcl1-1 was identified in a screen for mutants defective in chromosome segregation. Missegregation of the chromosomes in mcl1-1 mutant cells results from decreased centromeric cohesion between sister chromatids. mcl1 + encodes a β-transducin-like protein with similarity to a family of eukaryotic proteins that includes Ctf4p from Saccharomyces cerevisiae , sepB from Aspergillus nidulans , and AND-1 from humans. The previously identified fungal members of this protein family also have chromosome segregation defects, but they primarily affect DNA metabolism. Chromosomes from mcl1-1 cells were heterogeneous in size or structure on pulsed-field electrophoresis gels and had elongated heterogeneous telomeres. mcl1-1 was lethal in combination with the DNA checkpoint mutations rad3Δ and rad26Δ , demonstrating that loss of Mcl1p function leads to DNA damage. mcl1-1 showed an acute sensitivity to DNA damage that affects S-phase progression. It interacts genetically with replication components and causes an S-phase delay when overexpressed. We propose that Mcl1p, like Ctf4p, has a role in regulating DNA replication complexes." @default.
• W2047337895 created "2016-06-24" @default.
• W2047337895 creator A5038121623 @default.
• W2047337895 creator A5083476111 @default.
• W2047337895 date "2002-10-01" @default.
• W2047337895 modified "2023-10-16" @default.
• W2047337895 title "<i> mcl1 ⁺ </i> , the <i>Schizosaccharomyces pombe</i> Homologue of <i>CTF4</i> , Is Important for Chromosome Replication, Cohesion, and Segregation" @default.
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• W2047337895 doi "https://doi.org/10.1128/ec.1.5.758-773.2002" @default.
• W2047337895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/126746" @default.
• W2047337895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12455694" @default.
• W2047337895 hasPublicationYear "2002" @default.
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