FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047341441> ?p ?o ?g. }

• W2047341441 endingPage "263" @default.
• W2047341441 startingPage "256" @default.
• W2047341441 abstract "Cholesterol-enriched membrane microdomains (lipid rafts) play a role in the uptake of many pathogens. Mycobacteria are one of the intracellular pathogens that utilize lipid rafts in order to invade both phagocytic and non-phagocytic cells. However, the mechanism of Mycobacterium tuberculosis uptake by mast cell is not known. To address this issue, we investigated the interaction of M. tuberculosis (H37Rv strain) with mast cells. Confocal microscopy showed that interaction of mycobacterium with mast cell resulted in changes in the mast cell surface, with formation of pseudopod-like structure and activation with visibly extruded granules. Moreover, infection of mast cells with Mycobacteria induced cholesterol accumulation at the site of bacterial entry and around intracellular mycobacteria. Disruption of mast cells lipid rafts by cholesterol depletion markedly inhibited the mycobacterium entry. Intracellular multiplication of M. tuberculosis within mast cells was also observed. Overall, our results indicate that M. tuberculosis employs a cholesterol-dependent pathway to infect mast cells, which leads to degranulation and mast cell morphological changes. These results suggest that although mast cells are capable to respond to M. tuberculosis infection, entry of mycobacterium through lipid rafts may allow replication within mast cells." @default.
• W2047341441 created "2016-06-24" @default.
• W2047341441 creator A5035843815 @default.
• W2047341441 creator A5054752544 @default.
• W2047341441 creator A5079853305 @default.
• W2047341441 date "2009-09-01" @default.
• W2047341441 modified "2023-10-18" @default.
• W2047341441 title "<i>Mycobacterium tuberculosis</i>Entry into Mast Cells Through Cholesterol-rich Membrane Microdomains" @default.
• W2047341441 cites W1548106543 @default.
• W2047341441 cites W1552134204 @default.
• W2047341441 cites W1559544264 @default.
• W2047341441 cites W1579749431 @default.
• W2047341441 cites W1845375977 @default.
• W2047341441 cites W1933647785 @default.
• W2047341441 cites W1972902340 @default.
• W2047341441 cites W1978278349 @default.
• W2047341441 cites W1994149926 @default.
• W2047341441 cites W1996631459 @default.
• W2047341441 cites W2012416622 @default.
• W2047341441 cites W2013972132 @default.
• W2047341441 cites W2015347323 @default.
• W2047341441 cites W2015425628 @default.
• W2047341441 cites W2024388356 @default.
• W2047341441 cites W2036428031 @default.
• W2047341441 cites W2055472767 @default.
• W2047341441 cites W2061677679 @default.
• W2047341441 cites W2062173234 @default.
• W2047341441 cites W2065886456 @default.
• W2047341441 cites W2078299535 @default.
• W2047341441 cites W2099770366 @default.
• W2047341441 cites W2108598406 @default.
• W2047341441 cites W2113888821 @default.
• W2047341441 cites W2123463800 @default.
• W2047341441 cites W2124001620 @default.
• W2047341441 cites W2130779504 @default.
• W2047341441 cites W2142133586 @default.
• W2047341441 cites W2143303543 @default.
• W2047341441 cites W2144666859 @default.
• W2047341441 cites W2151612737 @default.
• W2047341441 cites W2159233432 @default.
• W2047341441 cites W2165094248 @default.
• W2047341441 cites W2167806590 @default.
• W2047341441 cites W2172074062 @default.
• W2047341441 doi "https://doi.org/10.1111/j.1365-3083.2009.02295.x" @default.
• W2047341441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19703015" @default.
• W2047341441 hasPublicationYear "2009" @default.
• W2047341441 type Work @default.
• W2047341441 sameAs 2047341441 @default.
• W2047341441 citedByCount "50" @default.
• W2047341441 countsByYear W20473414412012 @default.
• W2047341441 countsByYear W20473414412013 @default.
• W2047341441 countsByYear W20473414412014 @default.
• W2047341441 countsByYear W20473414412015 @default.
• W2047341441 countsByYear W20473414412016 @default.
• W2047341441 countsByYear W20473414412017 @default.
• W2047341441 countsByYear W20473414412018 @default.
• W2047341441 countsByYear W20473414412019 @default.
• W2047341441 countsByYear W20473414412020 @default.
• W2047341441 countsByYear W20473414412021 @default.
• W2047341441 countsByYear W20473414412022 @default.
• W2047341441 countsByYear W20473414412023 @default.
• W2047341441 crossrefType "journal-article" @default.
• W2047341441 hasAuthorship W2047341441A5035843815 @default.
• W2047341441 hasAuthorship W2047341441A5054752544 @default.
• W2047341441 hasAuthorship W2047341441A5079853305 @default.
• W2047341441 hasConcept C142724271 @default.
• W2047341441 hasConcept C153726182 @default.
• W2047341441 hasConcept C170493617 @default.
• W2047341441 hasConcept C203014093 @default.
• W2047341441 hasConcept C2777975735 @default.
• W2047341441 hasConcept C2779726688 @default.
• W2047341441 hasConcept C2781069245 @default.
• W2047341441 hasConcept C49802076 @default.
• W2047341441 hasConcept C55493867 @default.
• W2047341441 hasConcept C62478195 @default.
• W2047341441 hasConcept C71924100 @default.
• W2047341441 hasConcept C79266657 @default.
• W2047341441 hasConcept C79879829 @default.
• W2047341441 hasConcept C86803240 @default.
• W2047341441 hasConcept C89423630 @default.
• W2047341441 hasConcept C95444343 @default.
• W2047341441 hasConceptScore W2047341441C142724271 @default.
• W2047341441 hasConceptScore W2047341441C153726182 @default.
• W2047341441 hasConceptScore W2047341441C170493617 @default.
• W2047341441 hasConceptScore W2047341441C203014093 @default.
• W2047341441 hasConceptScore W2047341441C2777975735 @default.
• W2047341441 hasConceptScore W2047341441C2779726688 @default.
• W2047341441 hasConceptScore W2047341441C2781069245 @default.
• W2047341441 hasConceptScore W2047341441C49802076 @default.
• W2047341441 hasConceptScore W2047341441C55493867 @default.
• W2047341441 hasConceptScore W2047341441C62478195 @default.
• W2047341441 hasConceptScore W2047341441C71924100 @default.
• W2047341441 hasConceptScore W2047341441C79266657 @default.
• W2047341441 hasConceptScore W2047341441C79879829 @default.
• W2047341441 hasConceptScore W2047341441C86803240 @default.
• W2047341441 hasConceptScore W2047341441C89423630 @default.
• W2047341441 hasConceptScore W2047341441C95444343 @default.
• W2047341441 hasIssue "3" @default.

• next