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• W2047342341 endingPage "626" @default.
• W2047342341 startingPage "615" @default.
• W2047342341 abstract "Abstract The main objective of this study was to evaluate the ability of folic acid‐functionalized diblock copolymer micelles to improve the delivery and uptake of two poorly water‐soluble anti‐tumor drugs, tamoxifen and paclitaxel, to cancer cells through folate receptor targeting. The diblock copolymer used in this study comprised a hydrophilic poly[2‐(methacryloyloxy)ethyl phosphorylcholine] (MPC) block, carrying at the chain end the folate targeting moiety, and a pH‐sensitive hydrophobic poly[2‐(diisopropylamino)ethyl methacrylate] (DPA) block (FA–MPC–DPA). The drug‐loading capacities of tamoxifen‐ and paclitaxel‐loaded micelles were determined by high performance liquid chromatography and the micelle dimensions were determined by dynamic light scattering and transmission electron microscopy. Cell viability studies were carried out on human chronic myelogenous leukaemia (K‐562) and colon carcinoma cell lines (Caco‐2) in order to demonstrate that drug‐loaded FA–MPC–DPA micelles exhibited higher cytotoxicities toward cancer cells than unfunctionalized MPC‐DPA micelles. Uptake studies confirmed that folate‐conjugated micelles led to increased drug uptake within cancer cells, demonstrating the expected selectivity toward these tumor cells. magnified image" @default.
• W2047342341 created "2016-06-24" @default.
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• W2047342341 date "2008-07-07" @default.
• W2047342341 modified "2023-10-10" @default.
• W2047342341 title "<i>in vitro</i>Biological Evaluation of Folate-Functionalized Block Copolymer Micelles for Selective Anti-Cancer Drug Delivery" @default.
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• W2047342341 doi "https://doi.org/10.1002/mabi.200800009" @default.
• W2047342341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18432597" @default.
• W2047342341 hasPublicationYear "2008" @default.
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