Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047345480> ?p ?o ?g. }
- W2047345480 endingPage "3022" @default.
- W2047345480 startingPage "3008" @default.
- W2047345480 abstract "Sialic acid (Sia) is a family of acidic nine-carbon sugars that occupies the nonreducing terminus of glycan chains. Diversity of Sia is achieved by variation in the linkage to the underlying sugar and modification of the Sia molecule. Here we identified Sia-dependent epitope specificity for GL7, a rat monoclonal antibody, to probe germinal centers upon T cell-dependent immunity. GL7 recognizes sialylated glycan(s), the alpha2,6-linked N-acetylneuraminic acid (Neu5Ac) on a lactosamine glycan chain(s), in both Sia modification- and Sia linkage-dependent manners. In mouse germinal center B cells, the expression of the GL7 epitope was upregulated due to the in situ repression of CMP-Neu5Ac hydroxylase (Cmah), the enzyme responsible for Sia modification of Neu5Ac to Neu5Gc. Such Cmah repression caused activation-dependent dynamic reduction of CD22 ligand expression without losing alpha2,6-linked sialylation in germinal centers. The in vivo function of Cmah was analyzed using gene-disrupted mice. Phenotypic analyses showed that Neu5Gc glycan functions as a negative regulator for B-cell activation in assays of T-cell-independent immunization response and splenic B-cell proliferation. Thus, Neu5Gc is required for optimal negative regulation, and the reaction is specifically suppressed in activated B cells, i.e., germinal center B cells." @default.
- W2047345480 created "2016-06-24" @default.
- W2047345480 creator A5016000795 @default.
- W2047345480 creator A5023708168 @default.
- W2047345480 creator A5031610276 @default.
- W2047345480 creator A5031683902 @default.
- W2047345480 creator A5039202062 @default.
- W2047345480 creator A5039560593 @default.
- W2047345480 creator A5039931379 @default.
- W2047345480 creator A5040414662 @default.
- W2047345480 creator A5046211758 @default.
- W2047345480 creator A5049034922 @default.
- W2047345480 creator A5049975826 @default.
- W2047345480 creator A5052020814 @default.
- W2047345480 creator A5067236710 @default.
- W2047345480 creator A5070807450 @default.
- W2047345480 creator A5089799084 @default.
- W2047345480 date "2007-04-01" @default.
- W2047345480 modified "2023-10-03" @default.
- W2047345480 title "Germinal Center Marker GL7 Probes Activation-Dependent Repression of <i>N</i>-Glycolylneuraminic Acid, a Sialic Acid Species Involved in the Negative Modulation of B-Cell Activation" @default.
- W2047345480 cites W1488500980 @default.
- W2047345480 cites W1495825919 @default.
- W2047345480 cites W1562416468 @default.
- W2047345480 cites W1566693207 @default.
- W2047345480 cites W1592923741 @default.
- W2047345480 cites W1598208068 @default.
- W2047345480 cites W1632566425 @default.
- W2047345480 cites W1949917588 @default.
- W2047345480 cites W1972861232 @default.
- W2047345480 cites W1975933816 @default.
- W2047345480 cites W1976790385 @default.
- W2047345480 cites W1980268334 @default.
- W2047345480 cites W1982131071 @default.
- W2047345480 cites W1988621302 @default.
- W2047345480 cites W1991497659 @default.
- W2047345480 cites W1992076386 @default.
- W2047345480 cites W1997618940 @default.
- W2047345480 cites W2000993160 @default.
- W2047345480 cites W2001988677 @default.
- W2047345480 cites W2004308954 @default.
- W2047345480 cites W2025428983 @default.
- W2047345480 cites W2027922410 @default.
- W2047345480 cites W2035902011 @default.
- W2047345480 cites W2037681486 @default.
- W2047345480 cites W2041196497 @default.
- W2047345480 cites W2046065497 @default.
- W2047345480 cites W2046762204 @default.
- W2047345480 cites W2049570304 @default.
- W2047345480 cites W2049633866 @default.
- W2047345480 cites W2055741560 @default.
- W2047345480 cites W2057289747 @default.
- W2047345480 cites W2064597799 @default.
- W2047345480 cites W2066735040 @default.
- W2047345480 cites W2068592712 @default.
- W2047345480 cites W2077449764 @default.
- W2047345480 cites W2079639446 @default.
- W2047345480 cites W2092579180 @default.
- W2047345480 cites W2094167497 @default.
- W2047345480 cites W2098062600 @default.
- W2047345480 cites W2103986220 @default.
- W2047345480 cites W2107121913 @default.
- W2047345480 cites W2107170234 @default.
- W2047345480 cites W2109935462 @default.
- W2047345480 cites W2110086551 @default.
- W2047345480 cites W2116021132 @default.
- W2047345480 cites W2120121992 @default.
- W2047345480 cites W2122447210 @default.
- W2047345480 cites W2126043518 @default.
- W2047345480 cites W2133535267 @default.
- W2047345480 cites W2133628492 @default.
- W2047345480 cites W2137598151 @default.
- W2047345480 cites W2139387072 @default.
- W2047345480 cites W2142757238 @default.
- W2047345480 cites W2147246240 @default.
- W2047345480 cites W2148932927 @default.
- W2047345480 cites W2150235363 @default.
- W2047345480 cites W2150380845 @default.
- W2047345480 cites W2154872900 @default.
- W2047345480 cites W2155173012 @default.
- W2047345480 cites W2158004797 @default.
- W2047345480 cites W2158299621 @default.
- W2047345480 cites W2280026738 @default.
- W2047345480 cites W2333723852 @default.
- W2047345480 cites W2404159596 @default.
- W2047345480 cites W4251633039 @default.
- W2047345480 doi "https://doi.org/10.1128/mcb.02047-06" @default.
- W2047345480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1899932" @default.
- W2047345480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17296732" @default.
- W2047345480 hasPublicationYear "2007" @default.
- W2047345480 type Work @default.
- W2047345480 sameAs 2047345480 @default.
- W2047345480 citedByCount "168" @default.
- W2047345480 countsByYear W20473454802012 @default.
- W2047345480 countsByYear W20473454802013 @default.
- W2047345480 countsByYear W20473454802014 @default.
- W2047345480 countsByYear W20473454802015 @default.
- W2047345480 countsByYear W20473454802016 @default.
- W2047345480 countsByYear W20473454802017 @default.