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• W2047348775 abstract "The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally. Anti-genotoxic effects were assessed in the mouse bone marrow micronucleus test. Pretreatment with trans-anethole and eugenol led to significant antigenotoxic effects against cyclophosphamide (CPH), procarbazine (PCB), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and urethane (URE). In addition, trans-anethole inhibited the genotoxicity of ethyl methane sulfonate (EMS). Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE. There was no significant increase in genotoxicity when trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg body weight) were administered alone." @default.
• W2047348775 created "2016-06-24" @default.
• W2047348775 creator A5082293503 @default.
• W2047348775 date "2001-05-01" @default.
• W2047348775 modified "2023-10-01" @default.
• W2047348775 title "Anti-genotoxicity of trans-anethole and eugenol in mice" @default.
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• W2047348775 doi "https://doi.org/10.1016/s0278-6915(00)00156-3" @default.
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