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- W2047351514 abstract "The purpose of this study was to investigate the potential association of 2 polymorphisms in the CDKN2BAS and WNT4 previous GWAS studies reported with the risk of endometriosis in Korean women. Case-control study. Six hundred and seventy-three women with surgically or histologically diagnosed endometriosis were recruited for this study, and 502 patients with no evidence of endometriosis diagnosed by laparoscopy or laparotomy served as controls. The SNPs were assessed using the TaqMan allelic discrimination assay. There were statistically significant differences in the frequency of the rs10965235 in CDKN2BAS and rs16826658 in WNT4, independently, between the endometriosis patients and the controls. For the rs10965235 C/A polymorphism, the endometriosis group showed a higher frequency of CC genotype compared with the controls (69.7% versus 59.2%, P=0.001). For the rs16826658 polymorphism in WNT4, there was statistically difference between patients and the controls (33.7% GG, 48.4% GT, 17.8% TT versus 24.3%, 48.4%, 27.3%, respectively, P=0.000).Tabled 1Genotype and allele frequencies of CDKN2BAS and WNT4 SNPs in endometriosis patients and healthy controlsGenotypeTotal ES＃ (n=673)Stage I?II (n=124)Stage III (n=291)Stage IV (n=258)Control (n=502)CDKN2BAS C/C469 (69.7%)80 (64.5%)205 (70.4%)184 (71.3%)297 (59.2%)CDKN2BAS C/A181 (26.9%)37 (29.8%)75 (25.8%)69 (26.7%)177 (35.3%)CDKN2BAS A/A23 (3.4%)7 (5.6%)11 (3.8%)5 (1.9%)28 (5.6%)p value0.0010.5150.0060.002WNT4 16826658 G>G227 (33.7%)40 (32.3%)106 (36.4%)81 (31.4%)122 (24.3%)WNT4 16826658 G>T326 (48.4%)63 (50.8%)134 (46.0%)129 (50.0%)243 (48.4%)WNT4 16826658 T>T120 (17.8%)21 (16.9%)51 (17.5%)48 (18.6%)137 (27.3%)p value0.0000.0340.0000.014＃ES: endometriosis. Open table in a new tab ＃ES: endometriosis. Our results suggest that rs10965235 on CDKN2BAS gene and rs16826658 on WNT4 gene are associated with the endometriosis across the region." @default.
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- W2047351514 date "2013-09-01" @default.
- W2047351514 modified "2023-10-14" @default.
- W2047351514 title "An association study with two polymorphisms in CDKN2BAS and WNT4 identified through previous GWAS studies" @default.
- W2047351514 doi "https://doi.org/10.1016/j.fertnstert.2013.07.790" @default.
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