Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047362005> ?p ?o ?g. }
- W2047362005 endingPage "550" @default.
- W2047362005 startingPage "542" @default.
- W2047362005 abstract "As experimental evidence suggests that leptin may have direct effects on peripheral tissues, we investigated some of the transductional molecules induced by leptin in C2C12 cells. In immunoprecipitation experiments using anti-p85 antibodies (a regulatory subunit of phosphatidylinositol-3-kinase; PI3K), we observed a significant increase in PI3K activity. Immunoblot analyses showed that Akt, GSK3, ERK1, ERK2, and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation significantly increased after leptin treatment. Protein kinase C (PKC)-zeta was also activated by leptin, as documented by an immunocomplex kinase assay and immunoblotting experiments. The treatment of C2C12 cells with Wortmannin before leptin administration inhibited induction of the phosphorylation of ERKs (extracellular signal-regulated kinases) but not that of p38 MAPK, whereas pre-treatment with a PKC-zeta inhibitor partially decreased ERK phosphorylation. Taken together, our in vitro results further support the hypothesis that leptin acts acutely on skeletal muscle tissue through some of the components of insulin signalling, including PKC-zeta." @default.
- W2047362005 created "2016-06-24" @default.
- W2047362005 creator A5058863735 @default.
- W2047362005 creator A5073712287 @default.
- W2047362005 creator A5091078579 @default.
- W2047362005 date "2005-07-01" @default.
- W2047362005 modified "2023-10-10" @default.
- W2047362005 title "Intracellular signal transduction pathways induced by leptin in C2C12 cells" @default.
- W2047362005 cites W1487365829 @default.
- W2047362005 cites W1501363941 @default.
- W2047362005 cites W1542778840 @default.
- W2047362005 cites W1551216731 @default.
- W2047362005 cites W1666849257 @default.
- W2047362005 cites W186556958 @default.
- W2047362005 cites W1966803224 @default.
- W2047362005 cites W1968465405 @default.
- W2047362005 cites W1971379086 @default.
- W2047362005 cites W1972307668 @default.
- W2047362005 cites W1977795081 @default.
- W2047362005 cites W1980586168 @default.
- W2047362005 cites W1984969980 @default.
- W2047362005 cites W1987003441 @default.
- W2047362005 cites W1987355039 @default.
- W2047362005 cites W1989294105 @default.
- W2047362005 cites W1996713062 @default.
- W2047362005 cites W1998486087 @default.
- W2047362005 cites W2006272024 @default.
- W2047362005 cites W2009575166 @default.
- W2047362005 cites W2016746907 @default.
- W2047362005 cites W2018792346 @default.
- W2047362005 cites W2023555647 @default.
- W2047362005 cites W202438774 @default.
- W2047362005 cites W2025846514 @default.
- W2047362005 cites W2026200282 @default.
- W2047362005 cites W2035358854 @default.
- W2047362005 cites W2036441405 @default.
- W2047362005 cites W2045055190 @default.
- W2047362005 cites W2045200140 @default.
- W2047362005 cites W2050119840 @default.
- W2047362005 cites W2053394513 @default.
- W2047362005 cites W2054912558 @default.
- W2047362005 cites W205984844 @default.
- W2047362005 cites W2065171552 @default.
- W2047362005 cites W2066932627 @default.
- W2047362005 cites W2069720072 @default.
- W2047362005 cites W2074854146 @default.
- W2047362005 cites W2077378874 @default.
- W2047362005 cites W2077453058 @default.
- W2047362005 cites W2079538912 @default.
- W2047362005 cites W2079614270 @default.
- W2047362005 cites W2092721283 @default.
- W2047362005 cites W2101400542 @default.
- W2047362005 cites W2111081715 @default.
- W2047362005 cites W2118590328 @default.
- W2047362005 cites W2132038181 @default.
- W2047362005 cites W2139528348 @default.
- W2047362005 cites W2166603326 @default.
- W2047362005 cites W2168224573 @default.
- W2047362005 cites W2182343999 @default.
- W2047362005 doi "https://doi.org/10.1016/j.cellbi.2005.03.008" @default.
- W2047362005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15979910" @default.
- W2047362005 hasPublicationYear "2005" @default.
- W2047362005 type Work @default.
- W2047362005 sameAs 2047362005 @default.
- W2047362005 citedByCount "41" @default.
- W2047362005 countsByYear W20473620052012 @default.
- W2047362005 countsByYear W20473620052013 @default.
- W2047362005 countsByYear W20473620052014 @default.
- W2047362005 countsByYear W20473620052015 @default.
- W2047362005 countsByYear W20473620052019 @default.
- W2047362005 countsByYear W20473620052020 @default.
- W2047362005 countsByYear W20473620052021 @default.
- W2047362005 crossrefType "journal-article" @default.
- W2047362005 hasAuthorship W2047362005A5058863735 @default.
- W2047362005 hasAuthorship W2047362005A5073712287 @default.
- W2047362005 hasAuthorship W2047362005A5091078579 @default.
- W2047362005 hasConcept C11960822 @default.
- W2047362005 hasConcept C126322002 @default.
- W2047362005 hasConcept C134018914 @default.
- W2047362005 hasConcept C184235292 @default.
- W2047362005 hasConcept C185592680 @default.
- W2047362005 hasConcept C195794163 @default.
- W2047362005 hasConcept C2778308172 @default.
- W2047362005 hasConcept C2780610907 @default.
- W2047362005 hasConcept C2780613262 @default.
- W2047362005 hasConcept C511355011 @default.
- W2047362005 hasConcept C51551487 @default.
- W2047362005 hasConcept C57074206 @default.
- W2047362005 hasConcept C62478195 @default.
- W2047362005 hasConcept C71924100 @default.
- W2047362005 hasConcept C75217442 @default.
- W2047362005 hasConcept C86554907 @default.
- W2047362005 hasConcept C86803240 @default.
- W2047362005 hasConcept C95444343 @default.
- W2047362005 hasConcept C97029542 @default.
- W2047362005 hasConceptScore W2047362005C11960822 @default.
- W2047362005 hasConceptScore W2047362005C126322002 @default.
- W2047362005 hasConceptScore W2047362005C134018914 @default.