FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047362440> ?p ?o ?g. }

• W2047362440 endingPage "143" @default.
• W2047362440 startingPage "137" @default.
• W2047362440 abstract "Although metabolism of arsenicals to form methylated oxoarsenical species has been extensively studied, less is known about the formation of thiolated arsenical species that have recently been detected as urinary metabolites. Indeed, their presence suggests that the metabolism of ingested arsenic is more complex than previously thought. Recent reports have shown that thiolated arsenicals can be produced by the anaerobic microflora of the mouse cecum, suggesting that metabolism prior to systemic absorption may be a significant determinant of the pattern and extent of exposure to various arsenic-containing species. Here, we examined the metabolism of 34S labeled dimethylthioarsinic acid (34S-DMTAV) by the anaerobic microflora of the mouse cecum using HPLC–ICP-MS and HPLC–ESI-MS/MS to monitor for the presence of various oxo- and thioarsenicals. The use of isotopically enriched 34S-DMTAV made it possible to differentiate among potential metabolic pathways for production of the trimethylarsine sulfide (TMASV). Upon in vitro incubation in an assay containing anaerobic microflora of mouse cecum, 34S-DMTAV underwent several transformations. Labile 34S was exchanged with more abundant 32S to produce 32S-DMTAV, a thiol group was added to yield DMDTAV, and a methyl group was added to yield 34S-TMASV. Because incubation of 34S-DMTAV resulted in the formation of 34S-TMASV, the pathway for its formation must preserve the arsenic–sulfur bond. The alternative metabolic pathway postulated for formation of TMASV from dimethylarsinic acid (DMAV) would proceed via a dimethylarsinous acid (DMAIII) intermediate and would necessitate the loss of 34S label. Structural confirmation of the metabolic product was achieved using HPLC–ESI-MS/MS. The data presented support the direct methylation of DMTAV to TMASV. Additionally, the detection of isotopically pure 34S-TMASV raises questions about the sulfur exchange properties of TMASV in the cecum material. Therefore, 34S-TMASV was incubated and the exchange was monitored with respect to time. The data suggest that the As–S bond associated with TMASV is less labile than the As–S bond associated with DMTAV." @default.
• W2047362440 created "2016-06-24" @default.
• W2047362440 creator A5016988546 @default.
• W2047362440 creator A5059862147 @default.
• W2047362440 creator A5068076458 @default.
• W2047362440 creator A5078217119 @default.
• W2047362440 creator A5085083035 @default.
• W2047362440 date "2009-09-01" @default.
• W2047362440 modified "2023-09-23" @default.
• W2047362440 title "Exploring the in vitro formation of trimethylarsine sulfide from dimethylthioarsinic acid in anaerobic microflora of mouse cecum using HPLC–ICP-MS and HPLC–ESI-MS" @default.
• W2047362440 cites W1776292060 @default.
• W2047362440 cites W1964023826 @default.
• W2047362440 cites W1970753836 @default.
• W2047362440 cites W1972497117 @default.
• W2047362440 cites W1984958416 @default.
• W2047362440 cites W1986054311 @default.
• W2047362440 cites W1987559481 @default.
• W2047362440 cites W1990830351 @default.
• W2047362440 cites W1994054454 @default.
• W2047362440 cites W1996125511 @default.
• W2047362440 cites W1999899529 @default.
• W2047362440 cites W2010376281 @default.
• W2047362440 cites W2017737802 @default.
• W2047362440 cites W2024684401 @default.
• W2047362440 cites W2032475003 @default.
• W2047362440 cites W2032919955 @default.
• W2047362440 cites W2035866481 @default.
• W2047362440 cites W2061173203 @default.
• W2047362440 cites W2084313995 @default.
• W2047362440 cites W2086201153 @default.
• W2047362440 cites W2110164864 @default.
• W2047362440 cites W2113929416 @default.
• W2047362440 cites W2135699074 @default.
• W2047362440 cites W2138010930 @default.
• W2047362440 cites W2153523745 @default.
• W2047362440 cites W2153697541 @default.
• W2047362440 cites W2156990688 @default.
• W2047362440 cites W2158455449 @default.
• W2047362440 cites W4236207192 @default.
• W2047362440 cites W4239928604 @default.
• W2047362440 doi "https://doi.org/10.1016/j.taap.2008.12.008" @default.
• W2047362440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19133283" @default.
• W2047362440 hasPublicationYear "2009" @default.
• W2047362440 type Work @default.
• W2047362440 sameAs 2047362440 @default.
• W2047362440 citedByCount "62" @default.
• W2047362440 countsByYear W20473624402012 @default.
• W2047362440 countsByYear W20473624402013 @default.
• W2047362440 countsByYear W20473624402014 @default.
• W2047362440 countsByYear W20473624402015 @default.
• W2047362440 countsByYear W20473624402016 @default.
• W2047362440 countsByYear W20473624402017 @default.
• W2047362440 countsByYear W20473624402018 @default.
• W2047362440 countsByYear W20473624402019 @default.
• W2047362440 countsByYear W20473624402020 @default.
• W2047362440 countsByYear W20473624402022 @default.
• W2047362440 countsByYear W20473624402023 @default.
• W2047362440 crossrefType "journal-article" @default.
• W2047362440 hasAuthorship W2047362440A5016988546 @default.
• W2047362440 hasAuthorship W2047362440A5059862147 @default.
• W2047362440 hasAuthorship W2047362440A5068076458 @default.
• W2047362440 hasAuthorship W2047362440A5078217119 @default.
• W2047362440 hasAuthorship W2047362440A5085083035 @default.
• W2047362440 hasConcept C151730666 @default.
• W2047362440 hasConcept C178790620 @default.
• W2047362440 hasConcept C179998833 @default.
• W2047362440 hasConcept C185592680 @default.
• W2047362440 hasConcept C18903297 @default.
• W2047362440 hasConcept C192989942 @default.
• W2047362440 hasConcept C25642318 @default.
• W2047362440 hasConcept C2776152364 @default.
• W2047362440 hasConcept C2777507495 @default.
• W2047362440 hasConcept C2779870107 @default.
• W2047362440 hasConcept C2780416900 @default.
• W2047362440 hasConcept C2780596425 @default.
• W2047362440 hasConcept C42407357 @default.
• W2047362440 hasConcept C43617362 @default.
• W2047362440 hasConcept C5140985 @default.
• W2047362440 hasConcept C518881349 @default.
• W2047362440 hasConcept C55493867 @default.
• W2047362440 hasConcept C62231903 @default.
• W2047362440 hasConcept C86803240 @default.
• W2047362440 hasConceptScore W2047362440C151730666 @default.
• W2047362440 hasConceptScore W2047362440C178790620 @default.
• W2047362440 hasConceptScore W2047362440C179998833 @default.
• W2047362440 hasConceptScore W2047362440C185592680 @default.
• W2047362440 hasConceptScore W2047362440C18903297 @default.
• W2047362440 hasConceptScore W2047362440C192989942 @default.
• W2047362440 hasConceptScore W2047362440C25642318 @default.
• W2047362440 hasConceptScore W2047362440C2776152364 @default.
• W2047362440 hasConceptScore W2047362440C2777507495 @default.
• W2047362440 hasConceptScore W2047362440C2779870107 @default.
• W2047362440 hasConceptScore W2047362440C2780416900 @default.
• W2047362440 hasConceptScore W2047362440C2780596425 @default.
• W2047362440 hasConceptScore W2047362440C42407357 @default.
• W2047362440 hasConceptScore W2047362440C43617362 @default.
• W2047362440 hasConceptScore W2047362440C5140985 @default.
• W2047362440 hasConceptScore W2047362440C518881349 @default.

• next