FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047394452> ?p ?o ?g. }

• W2047394452 endingPage "118" @default.
• W2047394452 startingPage "109" @default.
• W2047394452 abstract "Phosphorylation/dephosphorylation of Ca2+ transport proteins by cellular kinases and phosphatases plays an important role in regulation of cardiac excitation-contraction coupling; furthermore abnormal protein kinase and phosphatase activities have been implicated in heart failure. However, the precise mechanisms of action of these enzymes on intracellular Ca2+ handling in normal and diseased hearts remains poorly understood. We have investigated the effects of protein phosphatases PP1 and PP2A on spontaneous Ca2+ sparks and SR Ca2+ load in myocytes permeabilized with saponin. Exposure of myocytes to PP1 or PP2A caused a dramatic increase in frequency of Ca2+ sparks followed by a nearly complete disappearance of events. These effects were accompanied by depletion of the SR Ca2+ stores, as determined by application of caffeine. These changes in Ca2+ release and SR Ca2+ load could be prevented by the inhibitors of PP1 and PP2A phosphatase activities okadaic acid and calyculin A. At the single channel level, PP1 increased the open probability of RyRs incorporated into lipid bilayers. PP1-mediated RyR dephosphorylation in our permeabilized myocytes preparations was confirmed biochemically by quantitative immunoblotting using a phosphospecific anti-RyR antibody. Our results suggest that increased intracellular phosphatase activity stimulates RyR-mediated SR Ca2+ release leading to depleted SR Ca2+ stores in cardiac myocytes." @default.
• W2047394452 created "2016-06-24" @default.
• W2047394452 creator A5000179751 @default.
• W2047394452 creator A5011626611 @default.
• W2047394452 creator A5031076992 @default.
• W2047394452 creator A5069584083 @default.
• W2047394452 creator A5075692221 @default.
• W2047394452 date "2003-10-01" @default.
• W2047394452 modified "2023-09-26" @default.
• W2047394452 title "Protein Phosphatases Decrease Sarcoplasmic Reticulum Calcium Content by Stimulating Calcium Release in Cardiac Myocytes" @default.
• W2047394452 cites W1483351525 @default.
• W2047394452 cites W166385710 @default.
• W2047394452 cites W1798047275 @default.
• W2047394452 cites W1851168822 @default.
• W2047394452 cites W1967111809 @default.
• W2047394452 cites W1980720980 @default.
• W2047394452 cites W1984180061 @default.
• W2047394452 cites W2002244635 @default.
• W2047394452 cites W2005419514 @default.
• W2047394452 cites W2011038097 @default.
• W2047394452 cites W2028165798 @default.
• W2047394452 cites W2029853313 @default.
• W2047394452 cites W2034507492 @default.
• W2047394452 cites W2039230734 @default.
• W2047394452 cites W2050824263 @default.
• W2047394452 cites W2055458221 @default.
• W2047394452 cites W2057906587 @default.
• W2047394452 cites W2060055554 @default.
• W2047394452 cites W2072719128 @default.
• W2047394452 cites W2080457705 @default.
• W2047394452 cites W2082823804 @default.
• W2047394452 cites W2090236692 @default.
• W2047394452 cites W2090362748 @default.
• W2047394452 cites W2095450310 @default.
• W2047394452 cites W2106104578 @default.
• W2047394452 cites W2110743357 @default.
• W2047394452 cites W2112483397 @default.
• W2047394452 cites W2119260303 @default.
• W2047394452 cites W2123095614 @default.
• W2047394452 cites W2125738242 @default.
• W2047394452 cites W2131133264 @default.
• W2047394452 cites W2139541709 @default.
• W2047394452 cites W2140313980 @default.
• W2047394452 cites W2140732346 @default.
• W2047394452 cites W2142567715 @default.
• W2047394452 cites W2145484503 @default.
• W2047394452 cites W2155862846 @default.
• W2047394452 cites W2166142816 @default.
• W2047394452 cites W2169759136 @default.
• W2047394452 cites W2172196619 @default.
• W2047394452 cites W2464513308 @default.
• W2047394452 cites W4247277440 @default.
• W2047394452 cites W58055601 @default.
• W2047394452 cites W91862947 @default.
• W2047394452 doi "https://doi.org/10.1113/jphysiol.2003.046367" @default.
• W2047394452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2343319" @default.
• W2047394452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12897175" @default.
• W2047394452 hasPublicationYear "2003" @default.
• W2047394452 type Work @default.
• W2047394452 sameAs 2047394452 @default.
• W2047394452 citedByCount "79" @default.
• W2047394452 countsByYear W20473944522012 @default.
• W2047394452 countsByYear W20473944522013 @default.
• W2047394452 countsByYear W20473944522014 @default.
• W2047394452 countsByYear W20473944522015 @default.
• W2047394452 countsByYear W20473944522016 @default.
• W2047394452 countsByYear W20473944522017 @default.
• W2047394452 countsByYear W20473944522018 @default.
• W2047394452 countsByYear W20473944522020 @default.
• W2047394452 countsByYear W20473944522021 @default.
• W2047394452 countsByYear W20473944522022 @default.
• W2047394452 countsByYear W20473944522023 @default.
• W2047394452 crossrefType "journal-article" @default.
• W2047394452 hasAuthorship W2047394452A5000179751 @default.
• W2047394452 hasAuthorship W2047394452A5011626611 @default.
• W2047394452 hasAuthorship W2047394452A5031076992 @default.
• W2047394452 hasAuthorship W2047394452A5069584083 @default.
• W2047394452 hasAuthorship W2047394452A5075692221 @default.
• W2047394452 hasBestOaLocation W20473944522 @default.
• W2047394452 hasConcept C113217602 @default.
• W2047394452 hasConcept C11960822 @default.
• W2047394452 hasConcept C126322002 @default.
• W2047394452 hasConcept C158617107 @default.
• W2047394452 hasConcept C178666793 @default.
• W2047394452 hasConcept C178790620 @default.
• W2047394452 hasConcept C181912034 @default.
• W2047394452 hasConcept C185592680 @default.
• W2047394452 hasConcept C207200792 @default.
• W2047394452 hasConcept C2776953658 @default.
• W2047394452 hasConcept C389152 @default.
• W2047394452 hasConcept C519063684 @default.
• W2047394452 hasConcept C55493867 @default.
• W2047394452 hasConcept C71924100 @default.
• W2047394452 hasConcept C79879829 @default.
• W2047394452 hasConcept C86803240 @default.
• W2047394452 hasConcept C95444343 @default.
• W2047394452 hasConceptScore W2047394452C113217602 @default.
• W2047394452 hasConceptScore W2047394452C11960822 @default.

• next