FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047397273> ?p ?o ?g. }

• W2047397273 endingPage "163" @default.
• W2047397273 startingPage "151" @default.
• W2047397273 abstract "With topical treatment of skin diseases, the requirement of a high and reproducible drug uptake often still is not met. Moreover, drug targeting to specific skin strata may improve the use of agents which are prone to cause local unwanted effects. Recent investigations have indicated that improved uptake and skin targeting may become feasible by means of nanoparticular systems such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions (NE). Here we describe techniques to characterize drug loading to carrier systems and skin penetration profiles by using the lipophilic dye nile red as a model agent. Since the mode of drug association with the particle matrix may strongly influence the efficiency of skin targeting, parelectric spectroscopy (PS) was used to differentiate between matrix incorporation and attachment to the particle surface and fluorescence spectroscopy (FS) to solve dye distribution within NLC particles. Nile red was incorporated into the lipid matrix or the covering tensed shell, respectively, of SLN and NLC with all the lipids studied (Compritol, Precirol, oleic acid, Miglyol). In NLC, the dye was enriched in the liquid phase. Next, nile red concentrations were followed by image analysis of vertical sections of pigskin treated with dye-loaded nanoparticular dispersions and an oil-in-water cream for 4 and 8 h in vitro. Following the SLN dispersions, dye penetration increased about fourfold over the uptake obtained following the cream. NLC turned out less potent (<threefold increase) and penetration appeared even reduced when applying a NE. In contrast to previous studies with glucocorticoids attached to the surface of SLN, a targeting effect was not detected here. Therefore, drug targeting appears to be more strictly related to the mode of interaction of drug and particle than penetration enhancement." @default.
• W2047397273 created "2016-06-24" @default.
• W2047397273 creator A5009731881 @default.
• W2047397273 creator A5012481353 @default.
• W2047397273 creator A5040331202 @default.
• W2047397273 creator A5049499330 @default.
• W2047397273 creator A5050199611 @default.
• W2047397273 creator A5054344650 @default.
• W2047397273 creator A5061810156 @default.
• W2047397273 creator A5069300219 @default.
• W2047397273 creator A5073722520 @default.
• W2047397273 date "2005-12-01" @default.
• W2047397273 modified "2023-10-12" @default.
• W2047397273 title "Lipid nanoparticles for skin penetration enhancement—correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy" @default.
• W2047397273 cites W1543763253 @default.
• W2047397273 cites W1976923360 @default.
• W2047397273 cites W1977275550 @default.
• W2047397273 cites W1977755432 @default.
• W2047397273 cites W2012427617 @default.
• W2047397273 cites W2018249639 @default.
• W2047397273 cites W2041986910 @default.
• W2047397273 cites W2045566628 @default.
• W2047397273 cites W2046017386 @default.
• W2047397273 cites W2054189154 @default.
• W2047397273 cites W2058251022 @default.
• W2047397273 cites W2062454110 @default.
• W2047397273 cites W2086486721 @default.
• W2047397273 cites W2087327774 @default.
• W2047397273 cites W2094151571 @default.
• W2047397273 cites W2110572162 @default.
• W2047397273 cites W2119280206 @default.
• W2047397273 cites W2129762213 @default.
• W2047397273 cites W2134579258 @default.
• W2047397273 cites W2141162588 @default.
• W2047397273 cites W2142404968 @default.
• W2047397273 cites W2163624874 @default.
• W2047397273 cites W2320071942 @default.
• W2047397273 cites W4240821889 @default.
• W2047397273 doi "https://doi.org/10.1016/j.jconrel.2005.09.045" @default.
• W2047397273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16297487" @default.
• W2047397273 hasPublicationYear "2005" @default.
• W2047397273 type Work @default.
• W2047397273 sameAs 2047397273 @default.
• W2047397273 citedByCount "220" @default.
• W2047397273 countsByYear W20473972732012 @default.
• W2047397273 countsByYear W20473972732013 @default.
• W2047397273 countsByYear W20473972732014 @default.
• W2047397273 countsByYear W20473972732015 @default.
• W2047397273 countsByYear W20473972732016 @default.
• W2047397273 countsByYear W20473972732017 @default.
• W2047397273 countsByYear W20473972732018 @default.
• W2047397273 countsByYear W20473972732019 @default.
• W2047397273 countsByYear W20473972732020 @default.
• W2047397273 countsByYear W20473972732021 @default.
• W2047397273 countsByYear W20473972732022 @default.
• W2047397273 countsByYear W20473972732023 @default.
• W2047397273 crossrefType "journal-article" @default.
• W2047397273 hasAuthorship W2047397273A5009731881 @default.
• W2047397273 hasAuthorship W2047397273A5012481353 @default.
• W2047397273 hasAuthorship W2047397273A5040331202 @default.
• W2047397273 hasAuthorship W2047397273A5049499330 @default.
• W2047397273 hasAuthorship W2047397273A5050199611 @default.
• W2047397273 hasAuthorship W2047397273A5054344650 @default.
• W2047397273 hasAuthorship W2047397273A5061810156 @default.
• W2047397273 hasAuthorship W2047397273A5069300219 @default.
• W2047397273 hasAuthorship W2047397273A5073722520 @default.
• W2047397273 hasConcept C106487976 @default.
• W2047397273 hasConcept C120665830 @default.
• W2047397273 hasConcept C121332964 @default.
• W2047397273 hasConcept C12554922 @default.
• W2047397273 hasConcept C127413603 @default.
• W2047397273 hasConcept C13245373 @default.
• W2047397273 hasConcept C147789679 @default.
• W2047397273 hasConcept C155672457 @default.
• W2047397273 hasConcept C158711907 @default.
• W2047397273 hasConcept C171250308 @default.
• W2047397273 hasConcept C178790620 @default.
• W2047397273 hasConcept C185592680 @default.
• W2047397273 hasConcept C187530423 @default.
• W2047397273 hasConcept C192562407 @default.
• W2047397273 hasConcept C199529486 @default.
• W2047397273 hasConcept C2778086801 @default.
• W2047397273 hasConcept C2779820397 @default.
• W2047397273 hasConcept C2780035454 @default.
• W2047397273 hasConcept C2781403372 @default.
• W2047397273 hasConcept C42475967 @default.
• W2047397273 hasConcept C43617362 @default.
• W2047397273 hasConcept C55493867 @default.
• W2047397273 hasConcept C71924100 @default.
• W2047397273 hasConcept C80107235 @default.
• W2047397273 hasConcept C86803240 @default.
• W2047397273 hasConcept C91881484 @default.
• W2047397273 hasConcept C98274493 @default.
• W2047397273 hasConceptScore W2047397273C106487976 @default.
• W2047397273 hasConceptScore W2047397273C120665830 @default.
• W2047397273 hasConceptScore W2047397273C121332964 @default.
• W2047397273 hasConceptScore W2047397273C12554922 @default.
• W2047397273 hasConceptScore W2047397273C127413603 @default.

• next