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• W2047401682 abstract "The development of potent, orally bioavailable, and selective series of 5-amino-3-hydroxy-N(1-hydroxypropane-2-yl)isothiazole-4-carboxamidine inhibitors of MEK1 and MEK-2 kinase is described. Optimization of the carboxamidine and the phenoxyaniline group led to the identification of 55 which gave good potency as in vitro MEK1 inhibitors, and good oral exposure in rat." @default.
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• W2047401682 date "2006-11-01" @default.
• W2047401682 modified "2023-10-09" @default.
• W2047401682 title "Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors" @default.
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• W2047401682 doi "https://doi.org/10.1016/j.bmcl.2006.08.048" @default.
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