FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W204743721> ?p ?o ?g. }

• W204743721 endingPage "8" @default.
• W204743721 startingPage "562" @default.
• W204743721 abstract "Children with cyanotic congenital heart disease who undergo operation with cardiopulmonary bypass are at increased risk of thromboembolic or hemorrhagic complications, or both. Regulation of thrombin, a key enzyme in coagulation, is essential in preventing these complications. We therefore examined the in vitro capacity of plasma from 15 children with cyanotic congenital heart disease to generate thrombin and to inhibit 125I-thrombin before and after cardiopulmonary bypass. We also assessed whether thrombin had been generated in vivo by assaying levels of fibrinogen, thrombin-antithrombin III complexes, and D-dimer. Plasma levels of the thrombin inhibitors, antithrombin III, alpha-2-macroglobulin, and heparin cofactor II were also measured. Thrombin regulation was normal before operation. After cardiopulmonary bypass, the in vitro capacity to generate thrombin decreased by 50%, and this was primarily a result of hemodilution (31%). Similar postoperative decreases were noted in the levels of antithrombin III, heparin cofactor II, and alpha-2-macroglobulin (26% to 45%). However, the total in vitro plasma thrombin inhibitory capacity decreased by only 13%. Levels of thrombin-antithrombin III and D-dimer increased after operation, indicating that thrombin had been generated and inhibited in vivo. Clinically, there were no thromboembolic complications although six patients required replacement therapy for excessive small-vessel bleeding. In conclusion, thrombin regulation is significantly altered after cardiopulmonary bypass. Although thrombin is generated in vivo, the total residual capacity to do so is impaired because of hemodilution. Despite a concomitant decrease in thrombin inhibitor levels, the total residual in vitro capacity of plasma to inhibit thrombin is relatively spared. This suggests that after cardiopulmonary bypass the risk of hemorrhagic complications after an additional hemostatic challenge is relatively greater than the risk of thrombotic complications. This might be reflected in the predominance of hemorrhagic complications in our patients." @default.
• W204743721 created "2016-06-24" @default.
• W204743721 creator A5020654452 @default.
• W204743721 creator A5041374747 @default.
• W204743721 creator A5051881642 @default.
• W204743721 creator A5065517967 @default.
• W204743721 date "1994-02-01" @default.
• W204743721 modified "2023-09-27" @default.
• W204743721 title "Thrombin regulation in congenital heart disease after cardiopulmonary bypass operations." @default.
• W204743721 cites W104552217 @default.
• W204743721 cites W108362734 @default.
• W204743721 cites W1451026943 @default.
• W204743721 cites W147525296 @default.
• W204743721 cites W1560801910 @default.
• W204743721 cites W1967125883 @default.
• W204743721 cites W1975681745 @default.
• W204743721 cites W1978039741 @default.
• W204743721 cites W1983550917 @default.
• W204743721 cites W1995983649 @default.
• W204743721 cites W2002983094 @default.
• W204743721 cites W2004715973 @default.
• W204743721 cites W2014271187 @default.
• W204743721 cites W2019931947 @default.
• W204743721 cites W2024794144 @default.
• W204743721 cites W2035823633 @default.
• W204743721 cites W2040728824 @default.
• W204743721 cites W2043266913 @default.
• W204743721 cites W2045404102 @default.
• W204743721 cites W2055916713 @default.
• W204743721 cites W2057646315 @default.
• W204743721 cites W2067860787 @default.
• W204743721 cites W2071383958 @default.
• W204743721 cites W2071435247 @default.
• W204743721 cites W2076255107 @default.
• W204743721 cites W2095052109 @default.
• W204743721 cites W2145367315 @default.
• W204743721 cites W21802224 @default.
• W204743721 cites W2248564262 @default.
• W204743721 cites W2409923453 @default.
• W204743721 cites W2412527016 @default.
• W204743721 cites W2416792871 @default.
• W204743721 cites W2465954707 @default.
• W204743721 cites W32418578 @default.
• W204743721 cites W343078165 @default.
• W204743721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8302075" @default.
• W204743721 hasPublicationYear "1994" @default.
• W204743721 type Work @default.
• W204743721 sameAs 204743721 @default.
• W204743721 citedByCount "4" @default.
• W204743721 crossrefType "journal-article" @default.
• W204743721 hasAuthorship W204743721A5020654452 @default.
• W204743721 hasAuthorship W204743721A5041374747 @default.
• W204743721 hasAuthorship W204743721A5051881642 @default.
• W204743721 hasAuthorship W204743721A5065517967 @default.
• W204743721 hasConcept C126322002 @default.
• W204743721 hasConcept C134018914 @default.
• W204743721 hasConcept C150903083 @default.
• W204743721 hasConcept C164705383 @default.
• W204743721 hasConcept C207001950 @default.
• W204743721 hasConcept C2777292125 @default.
• W204743721 hasConcept C2777557582 @default.
• W204743721 hasConcept C2778382381 @default.
• W204743721 hasConcept C2778881276 @default.
• W204743721 hasConcept C2779026020 @default.
• W204743721 hasConcept C42219234 @default.
• W204743721 hasConcept C57002609 @default.
• W204743721 hasConcept C71924100 @default.
• W204743721 hasConcept C86803240 @default.
• W204743721 hasConcept C89560881 @default.
• W204743721 hasConcept C98274493 @default.
• W204743721 hasConceptScore W204743721C126322002 @default.
• W204743721 hasConceptScore W204743721C134018914 @default.
• W204743721 hasConceptScore W204743721C150903083 @default.
• W204743721 hasConceptScore W204743721C164705383 @default.
• W204743721 hasConceptScore W204743721C207001950 @default.
• W204743721 hasConceptScore W204743721C2777292125 @default.
• W204743721 hasConceptScore W204743721C2777557582 @default.
• W204743721 hasConceptScore W204743721C2778382381 @default.
• W204743721 hasConceptScore W204743721C2778881276 @default.
• W204743721 hasConceptScore W204743721C2779026020 @default.
• W204743721 hasConceptScore W204743721C42219234 @default.
• W204743721 hasConceptScore W204743721C57002609 @default.
• W204743721 hasConceptScore W204743721C71924100 @default.
• W204743721 hasConceptScore W204743721C86803240 @default.
• W204743721 hasConceptScore W204743721C89560881 @default.
• W204743721 hasConceptScore W204743721C98274493 @default.
• W204743721 hasIssue "2" @default.
• W204743721 hasLocation W2047437211 @default.
• W204743721 hasOpenAccess W204743721 @default.
• W204743721 hasPrimaryLocation W2047437211 @default.
• W204743721 hasRelatedWork W140142063 @default.
• W204743721 hasRelatedWork W1965534396 @default.
• W204743721 hasRelatedWork W2048676023 @default.
• W204743721 hasRelatedWork W2064314440 @default.
• W204743721 hasRelatedWork W2067441028 @default.
• W204743721 hasRelatedWork W2078452085 @default.
• W204743721 hasRelatedWork W2138849164 @default.
• W204743721 hasRelatedWork W2189518999 @default.

• next