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- W2047446506 abstract "Little is known about the mechanisms of impaired immune function in alcoholic patients. We have previously shown that ethanol consumption by mice alters copolymer-specific humoral and cellular immune responses. Does ethanol consumption eliminate suppressor T cells, allowing nonresponder mice to make humoral immune responses to poly(Glu50Tyr50) (GT)? Female C57BL/6 mice were fed a nutritionally complete liquid diet containing 35% ethanol-derived calories for up to 33 days. Control mice were fed an isocaloric control liquid diet or remained on a solid diet and water. Mice fed the ethanol-containing diet made GT-specific plaque-forming cell (PFC) responses, whereas mice fed liquid control or solid diets did not. Lymphocytes from ethanol liquid diet-consuming mice helped splenocytes from either solid or liquid control mice to make a GT-specific PFC response. The cells mediating help were nylon wool nonadherent, CD4-bearing T cells. These findings suggest that ethanol does not eliminate copolymer-specific suppressor cells, but instead alters the functional capability of helper T cells for humoral immune responses." @default.
- W2047446506 created "2016-06-24" @default.
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- W2047446506 date "1994-01-01" @default.
- W2047446506 modified "2023-10-16" @default.
- W2047446506 title "Phenotype of lymphocytes mediating copolymer-specific humoral immunity in ethanol-consuming C57BL/6 mice" @default.
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- W2047446506 doi "https://doi.org/10.1016/0741-8329(94)90011-6" @default.
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