Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047447205> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2047447205 endingPage "472" @default.
- W2047447205 startingPage "469" @default.
- W2047447205 abstract "There are numerous risk factors for the development of malignant melanoma. It has been documented that genetic predisposition exists but exogenous factors are also very important. In familial melanomas it has been well established that mutation in the CDKN2A gene which is located at chromosome 9 leads to a marked risk for malignant melanoma. This tumor-suppressor gene is important for the regulation of the cell cycle and mutation in this gene is associated also with an increased rate of pancreas cancer. The penetrance of this mutation is influenced by UV-energy. In addition it has been shown that a second cluster for the familial atypical nevus syndrome is located at chromosome 1p36. Patients with the rare disease xeroderma pigmentosum have a defect in the DNA-repair mechanism inherited in an autosomal recessive trait and therefore develop within the first 20 years of life numerous malignant skin tumours including malignant melanomas. But also in non-syndromic patients a decrease of DNA-repair ability may occur. It has been shown recently that reduced DNA-repair ability is an independent risk factor for malignant melanoma and may contribute to susceptibility to sunlight-induced melanoma among the general population. Other constitutional risk factors for the development of malignant melanoma are fair skin, red hair and blue eyes. The most important exogenous risk factor is UV-exposition. Extensive and repetitive sunburns before the age of 15 years are especially predisposing to malignant melanoma. The most important preventive measures are continuous sun-protection including avoidance of sun in noon time on tropical and subtropical places, wearing a hut and sunglasses and application of sun-screens with high sun-protection factor. Furthermore a regular check for changing moles is indicated in persons with multiple atypical nevi or a familial melanoma syndrome. Nowadays molecular genetic screenings are available within research projects for members of melanoma-prone families. The controversy of such possibilities is discussed." @default.
- W2047447205 created "2016-06-24" @default.
- W2047447205 creator A5047402726 @default.
- W2047447205 creator A5091442979 @default.
- W2047447205 date "2003-08-01" @default.
- W2047447205 modified "2023-09-26" @default.
- W2047447205 title "Genetische Beratung und DNA-Testung für Patienten mit erhöhtem Melanomrisiko" @default.
- W2047447205 doi "https://doi.org/10.1024/0040-5930.60.8.469" @default.
- W2047447205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14502854" @default.
- W2047447205 hasPublicationYear "2003" @default.
- W2047447205 type Work @default.
- W2047447205 sameAs 2047447205 @default.
- W2047447205 citedByCount "2" @default.
- W2047447205 countsByYear W20474472052022 @default.
- W2047447205 crossrefType "journal-article" @default.
- W2047447205 hasAuthorship W2047447205A5047402726 @default.
- W2047447205 hasAuthorship W2047447205A5091442979 @default.
- W2047447205 hasConcept C104317684 @default.
- W2047447205 hasConcept C121608353 @default.
- W2047447205 hasConcept C126322002 @default.
- W2047447205 hasConcept C127716648 @default.
- W2047447205 hasConcept C134935766 @default.
- W2047447205 hasConcept C16005928 @default.
- W2047447205 hasConcept C200544954 @default.
- W2047447205 hasConcept C2777658100 @default.
- W2047447205 hasConcept C2777789703 @default.
- W2047447205 hasConcept C2778378917 @default.
- W2047447205 hasConcept C2780265364 @default.
- W2047447205 hasConcept C2908647359 @default.
- W2047447205 hasConcept C502942594 @default.
- W2047447205 hasConcept C54355233 @default.
- W2047447205 hasConcept C71924100 @default.
- W2047447205 hasConcept C86803240 @default.
- W2047447205 hasConcept C99454951 @default.
- W2047447205 hasConceptScore W2047447205C104317684 @default.
- W2047447205 hasConceptScore W2047447205C121608353 @default.
- W2047447205 hasConceptScore W2047447205C126322002 @default.
- W2047447205 hasConceptScore W2047447205C127716648 @default.
- W2047447205 hasConceptScore W2047447205C134935766 @default.
- W2047447205 hasConceptScore W2047447205C16005928 @default.
- W2047447205 hasConceptScore W2047447205C200544954 @default.
- W2047447205 hasConceptScore W2047447205C2777658100 @default.
- W2047447205 hasConceptScore W2047447205C2777789703 @default.
- W2047447205 hasConceptScore W2047447205C2778378917 @default.
- W2047447205 hasConceptScore W2047447205C2780265364 @default.
- W2047447205 hasConceptScore W2047447205C2908647359 @default.
- W2047447205 hasConceptScore W2047447205C502942594 @default.
- W2047447205 hasConceptScore W2047447205C54355233 @default.
- W2047447205 hasConceptScore W2047447205C71924100 @default.
- W2047447205 hasConceptScore W2047447205C86803240 @default.
- W2047447205 hasConceptScore W2047447205C99454951 @default.
- W2047447205 hasIssue "8" @default.
- W2047447205 hasLocation W20474472051 @default.
- W2047447205 hasLocation W20474472052 @default.
- W2047447205 hasOpenAccess W2047447205 @default.
- W2047447205 hasPrimaryLocation W20474472051 @default.
- W2047447205 hasRelatedWork W135432848 @default.
- W2047447205 hasRelatedWork W1663620072 @default.
- W2047447205 hasRelatedWork W2047447205 @default.
- W2047447205 hasRelatedWork W2059125805 @default.
- W2047447205 hasRelatedWork W2107894024 @default.
- W2047447205 hasRelatedWork W2130814563 @default.
- W2047447205 hasRelatedWork W2145231135 @default.
- W2047447205 hasRelatedWork W2156894772 @default.
- W2047447205 hasRelatedWork W2537601741 @default.
- W2047447205 hasRelatedWork W2187326996 @default.
- W2047447205 hasVolume "60" @default.
- W2047447205 isParatext "false" @default.
- W2047447205 isRetracted "false" @default.
- W2047447205 magId "2047447205" @default.
- W2047447205 workType "article" @default.