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- W2047448302 abstract "Increasing evidence suggests that MDM2 oncoprotein participates in a complex array of interactions with a plethora of molecules, including cell-cycle and transcriptional regulators, as well as determinants of the cell differentiation and senescence. The tumorigenic potential of MDM2 is mainly determined by overexpression due to gene amplification, mRNA overexpression and possibly translational enhancement. Although artificially created mutations have been demonstrated to abolish normal MDM2 function, there is little information concerning its mutational status in human tissues. In this study, we screened all the functional domains of MDM2 for mutations in a series of 58 non-small cell lung carcinomas (NSCLCs), but none was found. Therefore, we report that MDM2 mutations are an extremely rare phenomenon of non-small cell lung carcinogenesis. A putative explanation for this observation may be the labyrinth of interactions necessary for cell viability, in which MDM2 takes part, a finding also supported by its stringent interspecies conservation." @default.
- W2047448302 created "2016-06-24" @default.
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- W2047448302 date "2000-11-01" @default.
- W2047448302 modified "2023-10-03" @default.
- W2047448302 title "Absence of mutations in the functional domains of the human MDM2 oncogene in non-small cell lung carcinomas" @default.
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- W2047448302 doi "https://doi.org/10.1016/s0027-5107(00)00110-x" @default.
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