Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047465027> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2047465027 abstract "Previously, it was reported that pretreatment with the centrally-acting cholinergic antagonist atropine, but not the peripherally-acting antagonist, methyl-atropine, may serve to attenuate the positive reinforcing properties of morphine and conversely, to enhance those of amphetamine as evidenced within a drug self-administration paradigm in rats. In parallel, evidence from several sources would suggest that there may be a functional relationship between the neurochemical mechanisms mediating these drugs' positive reinforcing properties and their seemingly paradoxical capacity to act as aversive stimuli, as evidenced within a conditioned taste aversion (CTA) paradigm. Accordingly, the present study undertook to examine whether a similar differential involvement of central cholinergic mechanisms established for these drugs' positive reinforcing effects may be obtained for morphine and amphetamine-induced CTA. Using a conventional CTA paradigm, animals were pretreated with either intraperitoneal (IP) atropine or methyl-atropine (0.6 mg/kg) 40 minutes prior to consuming a novel 0.1% saccharin solution. This taste stimulus was paired with IP injection of 15 mg/kg morphine or vehicle. Results showed that atropine (but not methyl-atropine) pretreatment served to attenuate the morphine CTA. In a second experiment, atropine-pretreatment failed to attenuate, and may have slightly potentiated, a CTA induced by 1 mg/kg amphetamine. Atropine pretreatment did not affect a CTA induced by the emetic agent, lithium chloride. Pretreatment with the peripherally-acting methyl-atropine had no effect on the amphetamine CTA and served, if anything, to slightly attenuate the lithium chloride CTA.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2047465027 created "2016-06-24" @default.
- W2047465027 creator A5027187552 @default.
- W2047465027 creator A5082271179 @default.
- W2047465027 creator A5091163471 @default.
- W2047465027 date "1987-11-01" @default.
- W2047465027 modified "2023-09-25" @default.
- W2047465027 title "Differential involvement of central cholinergic mechanisms in the aversive stimulus properties of morphine and amphetamine" @default.
- W2047465027 cites W1969404372 @default.
- W2047465027 cites W1990407463 @default.
- W2047465027 cites W1998096274 @default.
- W2047465027 cites W2009977786 @default.
- W2047465027 cites W2013982378 @default.
- W2047465027 cites W2020252129 @default.
- W2047465027 cites W2020476621 @default.
- W2047465027 cites W2020860451 @default.
- W2047465027 cites W2021020577 @default.
- W2047465027 cites W2021377896 @default.
- W2047465027 cites W2032315546 @default.
- W2047465027 cites W2041022523 @default.
- W2047465027 cites W2049396251 @default.
- W2047465027 cites W2050625418 @default.
- W2047465027 cites W2051202848 @default.
- W2047465027 cites W2060024081 @default.
- W2047465027 cites W2060996423 @default.
- W2047465027 cites W2075818532 @default.
- W2047465027 cites W2077343589 @default.
- W2047465027 cites W2077867285 @default.
- W2047465027 cites W2085866328 @default.
- W2047465027 cites W2104180491 @default.
- W2047465027 cites W2150083419 @default.
- W2047465027 cites W2153392198 @default.
- W2047465027 cites W2168240847 @default.
- W2047465027 cites W2464877407 @default.
- W2047465027 doi "https://doi.org/10.1016/0091-3057(87)90449-7" @default.
- W2047465027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3685067" @default.
- W2047465027 hasPublicationYear "1987" @default.
- W2047465027 type Work @default.
- W2047465027 sameAs 2047465027 @default.
- W2047465027 citedByCount "5" @default.
- W2047465027 crossrefType "journal-article" @default.
- W2047465027 hasAuthorship W2047465027A5027187552 @default.
- W2047465027 hasAuthorship W2047465027A5082271179 @default.
- W2047465027 hasAuthorship W2047465027A5091163471 @default.
- W2047465027 hasConcept C126322002 @default.
- W2047465027 hasConcept C15744967 @default.
- W2047465027 hasConcept C164742699 @default.
- W2047465027 hasConcept C169760540 @default.
- W2047465027 hasConcept C170493617 @default.
- W2047465027 hasConcept C185592680 @default.
- W2047465027 hasConcept C22885893 @default.
- W2047465027 hasConcept C2775859210 @default.
- W2047465027 hasConcept C2776885963 @default.
- W2047465027 hasConcept C2777193897 @default.
- W2047465027 hasConcept C2777389121 @default.
- W2047465027 hasConcept C42219234 @default.
- W2047465027 hasConcept C513476851 @default.
- W2047465027 hasConcept C71924100 @default.
- W2047465027 hasConcept C8868529 @default.
- W2047465027 hasConcept C98274493 @default.
- W2047465027 hasConceptScore W2047465027C126322002 @default.
- W2047465027 hasConceptScore W2047465027C15744967 @default.
- W2047465027 hasConceptScore W2047465027C164742699 @default.
- W2047465027 hasConceptScore W2047465027C169760540 @default.
- W2047465027 hasConceptScore W2047465027C170493617 @default.
- W2047465027 hasConceptScore W2047465027C185592680 @default.
- W2047465027 hasConceptScore W2047465027C22885893 @default.
- W2047465027 hasConceptScore W2047465027C2775859210 @default.
- W2047465027 hasConceptScore W2047465027C2776885963 @default.
- W2047465027 hasConceptScore W2047465027C2777193897 @default.
- W2047465027 hasConceptScore W2047465027C2777389121 @default.
- W2047465027 hasConceptScore W2047465027C42219234 @default.
- W2047465027 hasConceptScore W2047465027C513476851 @default.
- W2047465027 hasConceptScore W2047465027C71924100 @default.
- W2047465027 hasConceptScore W2047465027C8868529 @default.
- W2047465027 hasConceptScore W2047465027C98274493 @default.
- W2047465027 hasLocation W20474650271 @default.
- W2047465027 hasLocation W20474650272 @default.
- W2047465027 hasOpenAccess W2047465027 @default.
- W2047465027 hasPrimaryLocation W20474650271 @default.
- W2047465027 hasRelatedWork W1967041634 @default.
- W2047465027 hasRelatedWork W1977378953 @default.
- W2047465027 hasRelatedWork W1980783894 @default.
- W2047465027 hasRelatedWork W1988816382 @default.
- W2047465027 hasRelatedWork W2006101903 @default.
- W2047465027 hasRelatedWork W2040702259 @default.
- W2047465027 hasRelatedWork W2050520107 @default.
- W2047465027 hasRelatedWork W2072073000 @default.
- W2047465027 hasRelatedWork W2153392198 @default.
- W2047465027 hasRelatedWork W2319043424 @default.
- W2047465027 isParatext "false" @default.
- W2047465027 isRetracted "false" @default.
- W2047465027 magId "2047465027" @default.
- W2047465027 workType "article" @default.