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- W2047480139 abstract "In 6 infants (3 males, 3 females) with histologically proven nesidioblastosis (ranges blood glucose, blood insulin and insulin glucose ratio of 9-35 mg/dl, 8-68 mU/1 and 0.5-5.2 resp.), the cardiorespiratory effects of diazoxide treatment was studied. All infants were free from heart disease; birth weight range 3640-5020 g. Diazoxide (12-25 mg/kg/day) and chlorothiazide with continuous i.v. infusion of glucose (15-25 mg/kg/min) were given to all patients (7 times) before pancreatectomy and to 3 post pancreatectomy under daily control of weight change, fluid intake, respiratory and heart rate (RR and HR), heart and liver size and heart murmurs. Cardio-respiratory toxicity symptoms occurred in 7 of 10 instances. The failure symptoms were not related to fluid overload, neither to the diazoxide dose alone but rather to diazoxide dose in relation to the severity of the disease. We expressed this relationship as Toxicity Index (TI) by multiplying the diazoxide dose by the insulin/glucose ratio. All infants with TI ≥ 10.2 developed toxicity: significantly (p < 0.005) increased RR and HR, hepato- and cardiomegaly, heart murmur. TI (total range 1.4-78.5) was significantly higher in infants with than in those without toxicity: 30.2±23.6 (x±SD) vs 2.8±1.5, p < 0.05. TI can be used for estimating the potential risk of cardio-respiratory failure and for calculating a safe diazoxide dose in infants with nesidioblastosis." @default.
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- W2047480139 date "1986-10-01" @default.
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- W2047480139 title "43 CARDIO-RESPIRATORY COMPLICATIONS OF DIAZOXIDE TREATMENT IN NESIDIOBLASTOSIS" @default.
- W2047480139 doi "https://doi.org/10.1203/00006450-198610000-00097" @default.
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