FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047499523> ?p ?o ?g. }

• W2047499523 endingPage "e1490" @default.
• W2047499523 startingPage "e1490" @default.
• W2047499523 abstract "Methionine sulfoxide reductase A (MSRA) protects proteins from oxidation, and also helps remove reactive oxygen species (ROS) by recovering antioxidant enzymes inactivated by oxidation. Although its functions have been investigated extensively, little is known about the mechanism by which MSRA is regulated. Arrest defective 1 (ARD1) is an enzyme that catalyzes not only N-terminal acetylation as a cotranslational modification but also lysine acetylation as a posttranslational modification. ARD1, which is expressed in most cell types, is believed to participate in diverse biological processes, but its roles are poorly understood. Given that MSRA was hunted in a yeast two-hybrid screen with ARD1 as the bait, we here investigated whether ARD1 is a novel regulator of MSRA. ARD1 was shown to interact with and acetylate MSRA in both cells and test tubes. It specifically acetylated the K49 residue of MSRA, and by doing so repressed the enzymatic function of MSRA. ARD1 increased cellular levels of ROS, carbonylated proteins and DNA breaks under oxidative stress. Moreover, it promoted cell death induced by pro-oxidants, which was attenuated in MSRA-deficient cells. When mice were exposed to hyperoxic conditions for 2 days, their livers and kidneys were injured and protein carbonylation was increased. The oxidative tissue injury was more severe in ARD1 transgenic mice than in their wild-type littermates. In conclusion, ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA. ARD1 is a potential target for ameliorating oxidative injury or for potentiating ROS-producing anticancer agents." @default.
• W2047499523 created "2016-06-24" @default.
• W2047499523 creator A5004062555 @default.
• W2047499523 creator A5035895380 @default.
• W2047499523 creator A5038990452 @default.
• W2047499523 creator A5043987479 @default.
• W2047499523 creator A5066134195 @default.
• W2047499523 creator A5071188352 @default.
• W2047499523 creator A5001286463 @default.
• W2047499523 date "2014-10-23" @default.
• W2047499523 modified "2023-10-16" @default.
• W2047499523 title "Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A" @default.
• W2047499523 cites W1489497639 @default.
• W2047499523 cites W1968972540 @default.
• W2047499523 cites W1970572439 @default.
• W2047499523 cites W1976599392 @default.
• W2047499523 cites W1985775217 @default.
• W2047499523 cites W1990157475 @default.
• W2047499523 cites W1990171977 @default.
• W2047499523 cites W1994769872 @default.
• W2047499523 cites W1994924724 @default.
• W2047499523 cites W1997746607 @default.
• W2047499523 cites W1999704088 @default.
• W2047499523 cites W2000901659 @default.
• W2047499523 cites W2001908271 @default.
• W2047499523 cites W2006897037 @default.
• W2047499523 cites W2009476974 @default.
• W2047499523 cites W2011538447 @default.
• W2047499523 cites W2011667964 @default.
• W2047499523 cites W2014581397 @default.
• W2047499523 cites W2019405732 @default.
• W2047499523 cites W2027193440 @default.
• W2047499523 cites W2032608099 @default.
• W2047499523 cites W2037116841 @default.
• W2047499523 cites W2037403843 @default.
• W2047499523 cites W2037813091 @default.
• W2047499523 cites W2039213528 @default.
• W2047499523 cites W2039766204 @default.
• W2047499523 cites W2044036144 @default.
• W2047499523 cites W2048569323 @default.
• W2047499523 cites W2048725147 @default.
• W2047499523 cites W2070623737 @default.
• W2047499523 cites W2080106524 @default.
• W2047499523 cites W2088088066 @default.
• W2047499523 cites W2091147851 @default.
• W2047499523 cites W2091583229 @default.
• W2047499523 cites W2093931104 @default.
• W2047499523 cites W2094627135 @default.
• W2047499523 cites W2094945914 @default.
• W2047499523 cites W2102302089 @default.
• W2047499523 cites W2102472842 @default.
• W2047499523 cites W2113710155 @default.
• W2047499523 cites W2168000927 @default.
• W2047499523 cites W4230847303 @default.
• W2047499523 cites W2019277820 @default.
• W2047499523 doi "https://doi.org/10.1038/cddis.2014.456" @default.
• W2047499523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4649535" @default.
• W2047499523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25341044" @default.
• W2047499523 hasPublicationYear "2014" @default.
• W2047499523 type Work @default.
• W2047499523 sameAs 2047499523 @default.
• W2047499523 citedByCount "31" @default.
• W2047499523 countsByYear W20474995232015 @default.
• W2047499523 countsByYear W20474995232016 @default.
• W2047499523 countsByYear W20474995232017 @default.
• W2047499523 countsByYear W20474995232018 @default.
• W2047499523 countsByYear W20474995232019 @default.
• W2047499523 countsByYear W20474995232020 @default.
• W2047499523 countsByYear W20474995232021 @default.
• W2047499523 countsByYear W20474995232022 @default.
• W2047499523 countsByYear W20474995232023 @default.
• W2047499523 crossrefType "journal-article" @default.
• W2047499523 hasAuthorship W2047499523A5001286463 @default.
• W2047499523 hasAuthorship W2047499523A5004062555 @default.
• W2047499523 hasAuthorship W2047499523A5035895380 @default.
• W2047499523 hasAuthorship W2047499523A5038990452 @default.
• W2047499523 hasAuthorship W2047499523A5043987479 @default.
• W2047499523 hasAuthorship W2047499523A5066134195 @default.
• W2047499523 hasAuthorship W2047499523A5071188352 @default.
• W2047499523 hasBestOaLocation W20474995231 @default.
• W2047499523 hasConcept C104317684 @default.
• W2047499523 hasConcept C119157956 @default.
• W2047499523 hasConcept C185592680 @default.
• W2047499523 hasConcept C2776151105 @default.
• W2047499523 hasConcept C2777568990 @default.
• W2047499523 hasConcept C2778813780 @default.
• W2047499523 hasConcept C2779458865 @default.
• W2047499523 hasConcept C2780912031 @default.
• W2047499523 hasConcept C48349386 @default.
• W2047499523 hasConcept C515207424 @default.
• W2047499523 hasConcept C55493867 @default.
• W2047499523 hasConcept C57600042 @default.
• W2047499523 hasConcept C86803240 @default.
• W2047499523 hasConcept C95444343 @default.
• W2047499523 hasConceptScore W2047499523C104317684 @default.
• W2047499523 hasConceptScore W2047499523C119157956 @default.
• W2047499523 hasConceptScore W2047499523C185592680 @default.
• W2047499523 hasConceptScore W2047499523C2776151105 @default.

• next