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- W2047506055 abstract "Drug effects on the size of the exchangeable sulphate pool and the incorporation rate into costal cartilage in vivo were studied by a new double isotope method in growing mice of the N. M. R. I. strain. Adrenalectomy caused a significant decrease both in the size of the sulphate pool and the rate of sul-phation in cartilage. Hydrocortisone (a water soluble form), acetylsalicylic acid, oxyphenylbutazone and dimethyl-sulphoxide given in rather high doses had no effect on the sulphate pools or the sulphate incorporation rates. Hydrocortisone-acetate (in oil or suspension), prednisolone-acetate and dexamethasone all elicited a dose-dependent retardation of body growth and a considerable increase in the size both of the total sulphate pool and the pool per g body weight. The sulphation rate of the cartilage samples even at high doses was only moderately depressed by the steroids studied. Only prednisolone elicited a marked inhibition with a dose above 40 μg. Salazopyrin® (4 mg/day × 6) considerably decreased sulphate incorporation without affecting the size of the sulphate pool. Vitamin A caused a marked and dose-dependent increase in the sulphate pool and a moderate and dose-independent decrease in the sulphation of cartilage. l-Thyroxine up to a dose of 1 μg/day depressed sulphate incorporation, but a 10 times higher dose stimulated it. The sulphate pools displayed a graded elevation after increasing doses of l-thyroxine." @default.
- W2047506055 created "2016-06-24" @default.
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- W2047506055 date "2009-03-13" @default.
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- W2047506055 title "Effect of Adrenalectomy, Corticosteroids and some other Anti-Inflammatory Agents, Salazopyrin®, Thyroxine and Vitamin A on the Exchangeable Sulphate Pool and on Sulphate Incorporation in Vivo into Costal Cartilage of the Mouse" @default.
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- W2047506055 doi "https://doi.org/10.1111/j.1600-0773.1971.tb00603.x" @default.
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