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• W2047509928 endingPage "3922" @default.
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• W2047509928 abstract "A molecular hybridization approach is an emerging structural modification tool to design new molecules with improved pharmacophoric properties. In this study, 1,2,3-triazole-based Mycobacterium tuberculosis inhibitors and synthetic and natural product-based tricyclic (carbazole, dibenzo[b,d]furan, and dibenzo[b,d]thiophene) antimycobacterial agents were integrated in one molecular platform to prepare various novel clubbed 1,2,3-triazole hybrids using click chemistry. Structure–activity correlations and in vitro activity against M. tuberculosis strain H37Rv of new analogues revealed the order: dibenzo[b,d]thiophene > dibenzo[b,d]furan > 9-methyl-9H-carbazole series. Two of the most potent M. tuberculosis inhibitors 13h and 13q with MIC = 0.78 μg/mL (∼1.9 μM) displayed a low cytotoxicity and high selectivity index (50–255) against four different human cancer cell lines. These results together provided the potential importance of molecular hybridization and the development of triazole clubbed dibenzo[b,d]thiophene-based lead candidates to treat mycobacterial infections." @default.
• W2047509928 created "2016-06-24" @default.
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• W2047509928 date "2012-04-09" @default.
• W2047509928 modified "2023-10-11" @default.
• W2047509928 title "Design, Synthesis, and Structure–Activity Correlations of Novel Dibenzo[<i>b</i>,<i>d</i>]furan, Dibenzo[<i>b</i>,<i>d</i>]thiophene, and <i>N</i>-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of <i>Mycobacterium tuberculosis</i>" @default.
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• W2047509928 doi "https://doi.org/10.1021/jm300125e" @default.
• W2047509928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22449006" @default.
• W2047509928 hasPublicationYear "2012" @default.
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