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- W2047539063 abstract "The cure rates for childhood acute leukemia have dramatically improved to approximately 70% overal, with treatments that include intensive cytotoxic chemotherapy and, in some cases, hematopoietic stem cell transplantation. However, many children still die of their disease or of treatment-related toxicities. Even in patients that are cured, there can be significant and, not uncommonly debilitating, acute and late complications of treatment. Improved understanding of the molecular and cellular biology of leukemia and the increasing availability of high-throughput genomic techniques have facilitated the development of molecularly targeted therapies that have the potential to be more effective and less toxic than the standard approaches. In this article, we review the progress to date with agents that are showing promise in the treatment of childhood acute leukemia, including monoclonal antibodies, inhibitors of kinases and other signaling molecules (e.g., BCR–ABL, FLT3, farnesyltransferase, mTOR and γ-secretase), agents that target epigenetic regulation of gene expression (DNA methyltransferase inhibitors and histone deacetylase inhibitors) and proteasome inhibitors. For the specific agents in each of these classes, we summarize the published preclinical data and the clinical trials that have been completed, are in progress or are being planned for children with acute leukemia. Finally, we discuss potential challenges to the success of molecularly targeted therapy, including proper target identification, adequate targeting of leukemia stem cells, developing synergistic and tolerable combinations of agents and designing adequately powered clinical trials to test efficacy in molecularly defined subsets of patients." @default.
- W2047539063 created "2016-06-24" @default.
- W2047539063 creator A5007182073 @default.
- W2047539063 creator A5008703987 @default.
- W2047539063 creator A5019914745 @default.
- W2047539063 creator A5023214494 @default.
- W2047539063 creator A5080485119 @default.
- W2047539063 date "2009-04-01" @default.
- W2047539063 modified "2023-10-03" @default.
- W2047539063 title "Novel targeted drug therapies for the treatment of childhood acute leukemia" @default.
- W2047539063 cites W1486948598 @default.
- W2047539063 cites W1506423591 @default.
- W2047539063 cites W1534632891 @default.
- W2047539063 cites W1550565578 @default.
- W2047539063 cites W1598153470 @default.
- W2047539063 cites W1842764967 @default.
- W2047539063 cites W1965262464 @default.
- W2047539063 cites W1970384544 @default.
- W2047539063 cites W1972809192 @default.
- W2047539063 cites W1974674483 @default.
- W2047539063 cites W1975427849 @default.
- W2047539063 cites W1977715186 @default.
- W2047539063 cites W1980910331 @default.
- W2047539063 cites W1980952706 @default.
- W2047539063 cites W1981709629 @default.
- W2047539063 cites W1982023788 @default.
- W2047539063 cites W1983393070 @default.
- W2047539063 cites W1984065010 @default.
- W2047539063 cites W1987239635 @default.
- W2047539063 cites W1987446594 @default.
- W2047539063 cites W1988356885 @default.
- W2047539063 cites W1988377311 @default.
- W2047539063 cites W1988553741 @default.
- W2047539063 cites W1990564763 @default.
- W2047539063 cites W1993017155 @default.
- W2047539063 cites W1994309500 @default.
- W2047539063 cites W1996885535 @default.
- W2047539063 cites W2000589976 @default.
- W2047539063 cites W2001626604 @default.
- W2047539063 cites W2007757672 @default.
- W2047539063 cites W2009886857 @default.
- W2047539063 cites W2010305809 @default.
- W2047539063 cites W2011449061 @default.
- W2047539063 cites W2013194808 @default.
- W2047539063 cites W2013264080 @default.
- W2047539063 cites W2013313605 @default.
- W2047539063 cites W2016833582 @default.
- W2047539063 cites W2018527149 @default.
- W2047539063 cites W2018910109 @default.
- W2047539063 cites W2022307983 @default.
- W2047539063 cites W2025754007 @default.
- W2047539063 cites W2025780824 @default.
- W2047539063 cites W2028104399 @default.
- W2047539063 cites W2032095580 @default.
- W2047539063 cites W2034820298 @default.
- W2047539063 cites W2037154482 @default.
- W2047539063 cites W2040329520 @default.
- W2047539063 cites W2041197793 @default.
- W2047539063 cites W2042184886 @default.
- W2047539063 cites W2043722634 @default.
- W2047539063 cites W2044630988 @default.
- W2047539063 cites W2047803210 @default.
- W2047539063 cites W2051864842 @default.
- W2047539063 cites W2052386066 @default.
- W2047539063 cites W2055031213 @default.
- W2047539063 cites W2055671553 @default.
- W2047539063 cites W2057043319 @default.
- W2047539063 cites W2058858066 @default.
- W2047539063 cites W2060710804 @default.
- W2047539063 cites W2061096768 @default.
- W2047539063 cites W2063512315 @default.
- W2047539063 cites W2065406906 @default.
- W2047539063 cites W2066064966 @default.
- W2047539063 cites W2067656626 @default.
- W2047539063 cites W2069709802 @default.
- W2047539063 cites W2070308429 @default.
- W2047539063 cites W2074181164 @default.
- W2047539063 cites W2074725580 @default.
- W2047539063 cites W2076436122 @default.
- W2047539063 cites W2077777928 @default.
- W2047539063 cites W2078936160 @default.
- W2047539063 cites W2080380323 @default.
- W2047539063 cites W2082219113 @default.
- W2047539063 cites W2082408605 @default.
- W2047539063 cites W2084283720 @default.
- W2047539063 cites W2086404440 @default.
- W2047539063 cites W2086990980 @default.
- W2047539063 cites W2088892407 @default.
- W2047539063 cites W2089434047 @default.
- W2047539063 cites W2091291743 @default.
- W2047539063 cites W2092606584 @default.
- W2047539063 cites W2097946794 @default.
- W2047539063 cites W2102901804 @default.
- W2047539063 cites W2103894337 @default.
- W2047539063 cites W2105098746 @default.
- W2047539063 cites W2105434446 @default.
- W2047539063 cites W2107943299 @default.
- W2047539063 cites W2107968021 @default.