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• W2047562912 startingPage "590" @default.
• W2047562912 abstract "Alzheimer's disease (AD) is characterized by memory impairment leading to dementia, deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The major component of plaques is the amyloid beta peptide, A beta, whereas NFTs contain hyperphosphorylated forms of the microtubule-associated protein tau (tau). Familial AD (FAD) mutations either elevate A beta synthesis by favoring 'secretase' of the Alzheimer beta-amyloid precursor protein (APP) or enhance the fibrillogenic properties of this peptide. Mutations in the tau gene cause a different disease denoted FTPD-17, but suggest that the aberrant forms of tau seen in AD are unlikely to be benign. These findings imply a complex pathogenic cascade in AD and important goals of transgenic modeling are to capture and stratify this pathogenic process. Several laboratories have created APP transgenic (Tg) mice that exhibit AD-like amyloid pathology and A beta burdens. These Tg lines also exhibit deficits in spatial reference and/or working memory, with immunization against A beta attenuating both AD-associated phenotypes. Tangle-like pathologies are observed in mice expressing FTPD-17 mutant forms of tau, but florid tau pathologies based upon the wild type (wt) tau isoforms present in AD have proven more elusive. Creation of animal models with robust amyloid and tau pathologies, yet free of irrelevant confounding pathologies, remains a major objective in this field." @default.
• W2047562912 created "2016-06-24" @default.
• W2047562912 creator A5014473479 @default.
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• W2047562912 date "2003-09-01" @default.
• W2047562912 modified "2023-09-24" @default.
• W2047562912 title "Mouse models of Alzheimer's disease: The long and filamentous road" @default.
• W2047562912 cites W1480786153 @default.
• W2047562912 cites W1494074009 @default.
• W2047562912 cites W1504283291 @default.
• W2047562912 cites W1511517753 @default.
• W2047562912 cites W1543551659 @default.
• W2047562912 cites W1572812739 @default.
• W2047562912 cites W1584834830 @default.
• W2047562912 cites W1591952754 @default.
• W2047562912 cites W1619610860 @default.
• W2047562912 cites W1621971853 @default.
• W2047562912 cites W1645365656 @default.
• W2047562912 cites W1655404681 @default.
• W2047562912 cites W1667748077 @default.
• W2047562912 cites W1675105744 @default.
• W2047562912 cites W1693283493 @default.
• W2047562912 cites W1705725530 @default.
• W2047562912 cites W1754645121 @default.
• W2047562912 cites W1886575365 @default.
• W2047562912 cites W1965275873 @default.
• W2047562912 cites W1970363870 @default.
• W2047562912 cites W1972850922 @default.
• W2047562912 cites W1974760231 @default.
• W2047562912 cites W1977775233 @default.
• W2047562912 cites W1979004999 @default.
• W2047562912 cites W1980906872 @default.
• W2047562912 cites W1982487434 @default.
• W2047562912 cites W1995344309 @default.
• W2047562912 cites W1996772579 @default.
• W2047562912 cites W1997805873 @default.
• W2047562912 cites W2000917982 @default.
• W2047562912 cites W2001210466 @default.
• W2047562912 cites W2005681172 @default.
• W2047562912 cites W2008197060 @default.
• W2047562912 cites W2011617651 @default.
• W2047562912 cites W2013313629 @default.
• W2047562912 cites W2021590064 @default.
• W2047562912 cites W2022402045 @default.
• W2047562912 cites W2024041849 @default.
• W2047562912 cites W2026823930 @default.
• W2047562912 cites W2029695041 @default.
• W2047562912 cites W2030804652 @default.
• W2047562912 cites W2030817295 @default.
• W2047562912 cites W2032069891 @default.
• W2047562912 cites W2033796514 @default.
• W2047562912 cites W2035156043 @default.
• W2047562912 cites W2036362108 @default.
• W2047562912 cites W2037387044 @default.
• W2047562912 cites W2039517040 @default.
• W2047562912 cites W2041229701 @default.
• W2047562912 cites W2043090568 @default.
• W2047562912 cites W2048193733 @default.
• W2047562912 cites W2051516838 @default.
• W2047562912 cites W2053063666 @default.
• W2047562912 cites W2053116497 @default.
• W2047562912 cites W2056745213 @default.
• W2047562912 cites W2058570072 @default.
• W2047562912 cites W2058908104 @default.
• W2047562912 cites W2063236931 @default.
• W2047562912 cites W2063487262 @default.
• W2047562912 cites W2065586627 @default.
• W2047562912 cites W2069466136 @default.
• W2047562912 cites W2071953900 @default.
• W2047562912 cites W2073516240 @default.
• W2047562912 cites W2078658743 @default.
• W2047562912 cites W2081586704 @default.
• W2047562912 cites W2081998222 @default.
• W2047562912 cites W2082022687 @default.
• W2047562912 cites W2087000167 @default.
• W2047562912 cites W2088949968 @default.
• W2047562912 cites W2090150925 @default.
• W2047562912 cites W2097116790 @default.
• W2047562912 cites W2100295360 @default.
• W2047562912 cites W2100610042 @default.
• W2047562912 cites W2101077392 @default.
• W2047562912 cites W2101341993 @default.
• W2047562912 cites W2103440561 @default.
• W2047562912 cites W2105704879 @default.
• W2047562912 cites W2110888808 @default.
• W2047562912 cites W2112047897 @default.
• W2047562912 cites W2113467168 @default.
• W2047562912 cites W2113690827 @default.
• W2047562912 cites W2119556701 @default.
• W2047562912 cites W2120162345 @default.
• W2047562912 cites W2120178938 @default.
• W2047562912 cites W2120675188 @default.
• W2047562912 cites W2122065036 @default.
• W2047562912 cites W2126800086 @default.

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