Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047565145> ?p ?o ?g. }
- W2047565145 abstract "The effects of injections of naloxone, a universal opioid receptor antagonist, into the medial septal nucleus on hippocampal acetylcholine (ACh) release and behavior were investigated in freely moving rats by means of the microdialysis method. The injection of naloxone (2, 10 and 20 micrograms) produced a marked increase in hippocampal ACh release in a dose-dependent manner. These effects of naloxone were reversed by the post-injection of [D-Ala2, N-Me-Phe4, Gly-ol]-enkephalin (DAGO; 10 micrograms), an opioid mu receptor agonist. Furthermore, basal release of hippocampal ACh was significantly reduced by the injection of DAGO alone. It was also found that rats given an injection of naloxone showed an increase in motor activity and occasionally exhibited behavioral seizures. These effects of naloxone were also reversed by the post-injection of DAGO. The present results suggest that endogenous opioids ionically inhibit the activity of septo-hippocampal cholinergic neurons via mediation of mu opioid receptors in the medial septal nucleus. They also suggest that endogenous opioids modulate the incidence of seizures, at least in part, through opioid mu receptors in the medial septal nucleus." @default.
- W2047565145 created "2016-06-24" @default.
- W2047565145 creator A5028917344 @default.
- W2047565145 creator A5067410332 @default.
- W2047565145 date "1996-03-01" @default.
- W2047565145 modified "2023-09-26" @default.
- W2047565145 title "Medial septal injection of naloxone elevates acetylcholine release in the hippocampus and induces behavioral seizures in rats" @default.
- W2047565145 cites W1524642647 @default.
- W2047565145 cites W1597672052 @default.
- W2047565145 cites W1637481752 @default.
- W2047565145 cites W1938313559 @default.
- W2047565145 cites W1968346353 @default.
- W2047565145 cites W1969584906 @default.
- W2047565145 cites W1972197544 @default.
- W2047565145 cites W1976822607 @default.
- W2047565145 cites W1981126088 @default.
- W2047565145 cites W1993109188 @default.
- W2047565145 cites W1993249954 @default.
- W2047565145 cites W1996656520 @default.
- W2047565145 cites W1999315925 @default.
- W2047565145 cites W2000629119 @default.
- W2047565145 cites W2005743173 @default.
- W2047565145 cites W2007722971 @default.
- W2047565145 cites W2010907642 @default.
- W2047565145 cites W2011328458 @default.
- W2047565145 cites W2011645297 @default.
- W2047565145 cites W2011786689 @default.
- W2047565145 cites W2018434736 @default.
- W2047565145 cites W2022958944 @default.
- W2047565145 cites W2026273445 @default.
- W2047565145 cites W2028996074 @default.
- W2047565145 cites W2029118604 @default.
- W2047565145 cites W2032000696 @default.
- W2047565145 cites W2033319161 @default.
- W2047565145 cites W2033476408 @default.
- W2047565145 cites W2034887080 @default.
- W2047565145 cites W2038167291 @default.
- W2047565145 cites W2038881398 @default.
- W2047565145 cites W2046118004 @default.
- W2047565145 cites W2047679059 @default.
- W2047565145 cites W2049111961 @default.
- W2047565145 cites W2052968926 @default.
- W2047565145 cites W2055233838 @default.
- W2047565145 cites W2055681900 @default.
- W2047565145 cites W2068717279 @default.
- W2047565145 cites W2071292680 @default.
- W2047565145 cites W2076782958 @default.
- W2047565145 cites W2079988750 @default.
- W2047565145 cites W2086071731 @default.
- W2047565145 cites W2090214067 @default.
- W2047565145 cites W2092411461 @default.
- W2047565145 cites W2157172203 @default.
- W2047565145 cites W2197213595 @default.
- W2047565145 cites W2266600006 @default.
- W2047565145 cites W2299833214 @default.
- W2047565145 cites W2311442063 @default.
- W2047565145 cites W2409687529 @default.
- W2047565145 cites W2885914634 @default.
- W2047565145 doi "https://doi.org/10.1016/0006-8993(95)01287-7" @default.
- W2047565145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8724969" @default.
- W2047565145 hasPublicationYear "1996" @default.
- W2047565145 type Work @default.
- W2047565145 sameAs 2047565145 @default.
- W2047565145 citedByCount "33" @default.
- W2047565145 countsByYear W20475651452012 @default.
- W2047565145 countsByYear W20475651452013 @default.
- W2047565145 countsByYear W20475651452016 @default.
- W2047565145 countsByYear W20475651452018 @default.
- W2047565145 countsByYear W20475651452019 @default.
- W2047565145 countsByYear W20475651452021 @default.
- W2047565145 crossrefType "journal-article" @default.
- W2047565145 hasAuthorship W2047565145A5028917344 @default.
- W2047565145 hasAuthorship W2047565145A5067410332 @default.
- W2047565145 hasConcept C126322002 @default.
- W2047565145 hasConcept C134018914 @default.
- W2047565145 hasConcept C148762608 @default.
- W2047565145 hasConcept C170493617 @default.
- W2047565145 hasConcept C185592680 @default.
- W2047565145 hasConcept C2775910092 @default.
- W2047565145 hasConcept C2777803847 @default.
- W2047565145 hasConcept C2778750930 @default.
- W2047565145 hasConcept C2778938600 @default.
- W2047565145 hasConcept C2779886867 @default.
- W2047565145 hasConcept C2781063702 @default.
- W2047565145 hasConcept C2781161787 @default.
- W2047565145 hasConcept C3017995582 @default.
- W2047565145 hasConcept C42219234 @default.
- W2047565145 hasConcept C50156730 @default.
- W2047565145 hasConcept C529278444 @default.
- W2047565145 hasConcept C71924100 @default.
- W2047565145 hasConceptScore W2047565145C126322002 @default.
- W2047565145 hasConceptScore W2047565145C134018914 @default.
- W2047565145 hasConceptScore W2047565145C148762608 @default.
- W2047565145 hasConceptScore W2047565145C170493617 @default.
- W2047565145 hasConceptScore W2047565145C185592680 @default.
- W2047565145 hasConceptScore W2047565145C2775910092 @default.
- W2047565145 hasConceptScore W2047565145C2777803847 @default.
- W2047565145 hasConceptScore W2047565145C2778750930 @default.
- W2047565145 hasConceptScore W2047565145C2778938600 @default.
- W2047565145 hasConceptScore W2047565145C2779886867 @default.