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- W2047575897 abstract "Amplification of oncogenes in primary tumours may have prognostic and/or therapeutic significance for patients with breast cancer. We have studied HER2/neu and c-myc amplification together with steroid receptors in human primary breast tumours and related the outcome with (relapse-free) survival. A strong inverse correlation was found between HER2/neu amplification and the presence of oestrogen and progesterone receptors. Actuarial 5-years survival showed that breast cancer patients with c-myc amplification in their primary tumours experience a shorter relapse-free survival, especially in node-negative and in receptor-positive tumours, whereas HER2/neu amplification may be of prognostic value for overall survival in receptor-negative tumours. Overall, in our hands, c-myc amplification appeared to be a more potent prognosticator than HER2/neu amplification in human primary breast cancer." @default.
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- W2047575897 date "1992-09-01" @default.
- W2047575897 modified "2023-09-28" @default.
- W2047575897 title "Prognostic factors in human primary breast cancer: Comparison of c-myc and HER2/neu amplification" @default.
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- W2047575897 doi "https://doi.org/10.1016/0960-0760(92)90182-i" @default.
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