FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047581407> ?p ?o ?g. }

• W2047581407 endingPage "484" @default.
• W2047581407 startingPage "476" @default.
• W2047581407 abstract "Complement regulatory molecules, membrane cofactor protein (MCP), decay accelerating factor (DAF) and CD59, protect body cells from autologous complement. They have wide tissue distribution but nothing is known about the expression of these molecules on human melanocytes. Since melanocytes are lysed in the lesional skin of patients with a depigmentary disorder vitiligo, it is important to compare the protection offered by complement regulatory molecules to melanocytes present in normal and vitiligo epidermis, against autologous complement. From this point of view, we investigated the differential expression of MCP, DAF and CD59 on normal cultured human melanocytes and assessed their individual contribution in the protection of these cells against complement-mediated damage. Flow cytometric analysis showed that MCP and DAF but not CD59 were expressed on cultured melanocytes. When heat inactivated sera of patients with vitiligo were used as a source of anti-melanocyte antibody to sensitize melanocytes, and guinea pig serum (GpS) or normal human serum (NHS) as a source of complement, GpS was found to be more effective in causing the lysis of melanocytes than NHS. When melanocytes were sensitized with autoantibody as well as F(ab')2 fragment of either anti-MCP or anti-DAF and subsequently incubated with NHS or GpS, both antibody fragments increased the killing of melanocytes by NHS as well as by GpS. F(ab')2 fragment of anti-DAF was much more effective in causing enhancement of lysis than that of anti-MCP. Thus, cultured normal human melanocytes express functionally active MCP and DAF but not CD59. Contribution of DAF in protecting melanocytes against complement attack was much more than that of MCP" @default.
• W2047581407 created "2016-06-24" @default.
• W2047581407 creator A5001576050 @default.
• W2047581407 creator A5006074867 @default.
• W2047581407 creator A5028081447 @default.
• W2047581407 creator A5035589556 @default.
• W2047581407 creator A5060148852 @default.
• W2047581407 creator A5089104690 @default.
• W2047581407 date "1998-02-01" @default.
• W2047581407 modified "2023-09-29" @default.
• W2047581407 title "Relative Contributions of Decay Accelerating Factor (DAF), Membrane Cofactor Protein (MCP) and CD59 in the Protection of Melanocytes from Homologous Complement" @default.
• W2047581407 cites W1500833770 @default.
• W2047581407 cites W1505326537 @default.
• W2047581407 cites W1523029070 @default.
• W2047581407 cites W1529108748 @default.
• W2047581407 cites W1831186908 @default.
• W2047581407 cites W1975692389 @default.
• W2047581407 cites W1980384590 @default.
• W2047581407 cites W1982175857 @default.
• W2047581407 cites W1983395201 @default.
• W2047581407 cites W1990943556 @default.
• W2047581407 cites W1991775814 @default.
• W2047581407 cites W2018667055 @default.
• W2047581407 cites W2019652915 @default.
• W2047581407 cites W2028776659 @default.
• W2047581407 cites W2032360303 @default.
• W2047581407 cites W2037309942 @default.
• W2047581407 cites W2056933374 @default.
• W2047581407 cites W2066464304 @default.
• W2047581407 cites W2083708523 @default.
• W2047581407 cites W2085974517 @default.
• W2047581407 cites W2097252379 @default.
• W2047581407 cites W2104199760 @default.
• W2047581407 cites W2114918609 @default.
• W2047581407 cites W2129071590 @default.
• W2047581407 cites W2140971592 @default.
• W2047581407 cites W2151534309 @default.
• W2047581407 cites W2152020672 @default.
• W2047581407 doi "https://doi.org/10.1016/s0171-2985(98)80054-5" @default.
• W2047581407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9562871" @default.
• W2047581407 hasPublicationYear "1998" @default.
• W2047581407 type Work @default.
• W2047581407 sameAs 2047581407 @default.
• W2047581407 citedByCount "18" @default.
• W2047581407 countsByYear W20475814072012 @default.
• W2047581407 countsByYear W20475814072019 @default.
• W2047581407 countsByYear W20475814072020 @default.
• W2047581407 countsByYear W20475814072023 @default.
• W2047581407 crossrefType "journal-article" @default.
• W2047581407 hasAuthorship W2047581407A5001576050 @default.
• W2047581407 hasAuthorship W2047581407A5006074867 @default.
• W2047581407 hasAuthorship W2047581407A5028081447 @default.
• W2047581407 hasAuthorship W2047581407A5035589556 @default.
• W2047581407 hasAuthorship W2047581407A5060148852 @default.
• W2047581407 hasAuthorship W2047581407A5089104690 @default.
• W2047581407 hasConcept C111684460 @default.
• W2047581407 hasConcept C153911025 @default.
• W2047581407 hasConcept C159654299 @default.
• W2047581407 hasConcept C184404459 @default.
• W2047581407 hasConcept C185592680 @default.
• W2047581407 hasConcept C203014093 @default.
• W2047581407 hasConcept C2777658100 @default.
• W2047581407 hasConcept C2779769559 @default.
• W2047581407 hasConcept C2779980618 @default.
• W2047581407 hasConcept C502942594 @default.
• W2047581407 hasConcept C8487232 @default.
• W2047581407 hasConcept C86803240 @default.
• W2047581407 hasConcept C92731135 @default.
• W2047581407 hasConcept C95444343 @default.
• W2047581407 hasConceptScore W2047581407C111684460 @default.
• W2047581407 hasConceptScore W2047581407C153911025 @default.
• W2047581407 hasConceptScore W2047581407C159654299 @default.
• W2047581407 hasConceptScore W2047581407C184404459 @default.
• W2047581407 hasConceptScore W2047581407C185592680 @default.
• W2047581407 hasConceptScore W2047581407C203014093 @default.
• W2047581407 hasConceptScore W2047581407C2777658100 @default.
• W2047581407 hasConceptScore W2047581407C2779769559 @default.
• W2047581407 hasConceptScore W2047581407C2779980618 @default.
• W2047581407 hasConceptScore W2047581407C502942594 @default.
• W2047581407 hasConceptScore W2047581407C8487232 @default.
• W2047581407 hasConceptScore W2047581407C86803240 @default.
• W2047581407 hasConceptScore W2047581407C92731135 @default.
• W2047581407 hasConceptScore W2047581407C95444343 @default.
• W2047581407 hasIssue "4" @default.
• W2047581407 hasLocation W20475814071 @default.
• W2047581407 hasLocation W20475814072 @default.
• W2047581407 hasOpenAccess W2047581407 @default.
• W2047581407 hasPrimaryLocation W20475814071 @default.
• W2047581407 hasRelatedWork W143669654 @default.
• W2047581407 hasRelatedWork W2026272606 @default.
• W2047581407 hasRelatedWork W2047581407 @default.
• W2047581407 hasRelatedWork W2071848881 @default.
• W2047581407 hasRelatedWork W2086103133 @default.
• W2047581407 hasRelatedWork W2091209603 @default.
• W2047581407 hasRelatedWork W2104752358 @default.
• W2047581407 hasRelatedWork W2802751991 @default.
• W2047581407 hasRelatedWork W2894302087 @default.
• W2047581407 hasRelatedWork W4313325025 @default.

• next