FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047581574> ?p ?o ?g. }

• W2047581574 endingPage "143" @default.
• W2047581574 startingPage "133" @default.
• W2047581574 abstract "1,25-Dihydroxyvitamin-D3 [1,25(OH)2D3], the active hormonal metabolite of vitamin D, acts through a specific nuclear receptor to inhibit proliferation and promote differentiation of several tumor cell types including the LNCaP, DU145 and PC-3 prostate cancer cell lines as well as primary prostate tumor lines. 1,25(OH)2D3 can also decrease invasion of breast and prostate cancer cell lines in vitro. We confirm this latter finding in the DU145 and PC-3 prostate cancer cell lines, and further show that 1,25(OH)2D3 inhibits overall invasion, cell adhesion and migration to the basement membrane matrix protein laminin. These changes appear to be due in part to a 1,25(OH)2D3-induced decrease in expression of alpha6 and beta4 integrins, both of which are receptors for laminin and associated with increased migration and invasion of prostate cancer cells in vitro. Blocking function of these particular integrins with antibodies inhibits both adhesion and migration of the cells. Collectively, these data demonstrate that 1,25(OH)2D3, in addition to decreasing proliferation of tumor cells, can also inhibit prostate cancer cell invasion through modulation of select cell surface adhesion molecules." @default.
• W2047581574 created "2016-06-24" @default.
• W2047581574 creator A5007098177 @default.
• W2047581574 creator A5036496348 @default.
• W2047581574 date "2000-06-01" @default.
• W2047581574 modified "2023-09-27" @default.
• W2047581574 title "1,25-Dihydroxyvitamin D3 decreases human prostate cancer cell adhesion and migration" @default.
• W2047581574 cites W1486598646 @default.
• W2047581574 cites W1514829409 @default.
• W2047581574 cites W1623258939 @default.
• W2047581574 cites W1965166566 @default.
• W2047581574 cites W1967120404 @default.
• W2047581574 cites W1968180643 @default.
• W2047581574 cites W1968503492 @default.
• W2047581574 cites W1969184967 @default.
• W2047581574 cites W1980830316 @default.
• W2047581574 cites W1982959949 @default.
• W2047581574 cites W1984466851 @default.
• W2047581574 cites W2007990336 @default.
• W2047581574 cites W2015010074 @default.
• W2047581574 cites W2019709040 @default.
• W2047581574 cites W2020445671 @default.
• W2047581574 cites W2025060260 @default.
• W2047581574 cites W2030565784 @default.
• W2047581574 cites W2033538744 @default.
• W2047581574 cites W2037287388 @default.
• W2047581574 cites W2041570722 @default.
• W2047581574 cites W2080502221 @default.
• W2047581574 cites W2084779586 @default.
• W2047581574 cites W2087145616 @default.
• W2047581574 cites W2095958938 @default.
• W2047581574 cites W2132045524 @default.
• W2047581574 cites W2146868272 @default.
• W2047581574 cites W2151493707 @default.
• W2047581574 cites W2164271213 @default.
• W2047581574 cites W2176697008 @default.
• W2047581574 cites W2316863237 @default.
• W2047581574 cites W338577634 @default.
• W2047581574 cites W4234090308 @default.
• W2047581574 cites W4242052585 @default.
• W2047581574 cites W4244955483 @default.
• W2047581574 cites W4254967846 @default.
• W2047581574 cites W4294216491 @default.
• W2047581574 cites W4298312879 @default.
• W2047581574 doi "https://doi.org/10.1016/s0303-7207(00)00226-4" @default.
• W2047581574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11026565" @default.
• W2047581574 hasPublicationYear "2000" @default.
• W2047581574 type Work @default.
• W2047581574 sameAs 2047581574 @default.
• W2047581574 citedByCount "107" @default.
• W2047581574 countsByYear W20475815742012 @default.
• W2047581574 countsByYear W20475815742013 @default.
• W2047581574 countsByYear W20475815742014 @default.
• W2047581574 countsByYear W20475815742015 @default.
• W2047581574 countsByYear W20475815742016 @default.
• W2047581574 countsByYear W20475815742017 @default.
• W2047581574 countsByYear W20475815742018 @default.
• W2047581574 countsByYear W20475815742019 @default.
• W2047581574 countsByYear W20475815742020 @default.
• W2047581574 countsByYear W20475815742021 @default.
• W2047581574 countsByYear W20475815742022 @default.
• W2047581574 countsByYear W20475815742023 @default.
• W2047581574 crossrefType "journal-article" @default.
• W2047581574 hasAuthorship W2047581574A5007098177 @default.
• W2047581574 hasAuthorship W2047581574A5036496348 @default.
• W2047581574 hasConcept C121608353 @default.
• W2047581574 hasConcept C126322002 @default.
• W2047581574 hasConcept C134018914 @default.
• W2047581574 hasConcept C1491633281 @default.
• W2047581574 hasConcept C16224149 @default.
• W2047581574 hasConcept C170493617 @default.
• W2047581574 hasConcept C185592680 @default.
• W2047581574 hasConcept C189165786 @default.
• W2047581574 hasConcept C195687474 @default.
• W2047581574 hasConcept C2776438761 @default.
• W2047581574 hasConcept C2779723316 @default.
• W2047581574 hasConcept C2779814568 @default.
• W2047581574 hasConcept C2780192828 @default.
• W2047581574 hasConcept C502942594 @default.
• W2047581574 hasConcept C54355233 @default.
• W2047581574 hasConcept C55493867 @default.
• W2047581574 hasConcept C62112901 @default.
• W2047581574 hasConcept C71924100 @default.
• W2047581574 hasConcept C81885089 @default.
• W2047581574 hasConcept C85789140 @default.
• W2047581574 hasConcept C86803240 @default.
• W2047581574 hasConcept C95444343 @default.
• W2047581574 hasConcept C96232424 @default.
• W2047581574 hasConceptScore W2047581574C121608353 @default.
• W2047581574 hasConceptScore W2047581574C126322002 @default.
• W2047581574 hasConceptScore W2047581574C134018914 @default.
• W2047581574 hasConceptScore W2047581574C1491633281 @default.
• W2047581574 hasConceptScore W2047581574C16224149 @default.
• W2047581574 hasConceptScore W2047581574C170493617 @default.
• W2047581574 hasConceptScore W2047581574C185592680 @default.
• W2047581574 hasConceptScore W2047581574C189165786 @default.
• W2047581574 hasConceptScore W2047581574C195687474 @default.
• W2047581574 hasConceptScore W2047581574C2776438761 @default.

• next