FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047582990> ?p ?o ?g. }

• W2047582990 endingPage "589" @default.
• W2047582990 startingPage "583" @default.
• W2047582990 abstract "OBJECTIVES Insulin-like growth factor-l (IGF-I) is a polypeptide growth factor that stimulates protein synthesis. The aims of this study were to determine (1) the effect of a severe burn on blood IGF-I levels and (2) the variables controlling IGF-I level variations during recovery of these hypermetabolic patients. PATIENTS Eleven patients, nine men and two women (age range 22–55 years) were studied for 25 days following a severe burn (18–75% of total body surface area, mean 36%). Nitrogen balances were recorded daily and total IGF-I levels were measured every 3 days. MEASUREMENTS IGF-I was extracted from serum using a validated formic acid-acetone methodology, then measured by a double antibody radioimmunoassay. IGF-I levels were compared to those of a reference healthy population. RESULTS Within 24 hours following injury, IGF-I levels were low in all patients when compared to normal values for the same age range (mean ± SEM of all patients, 131 ± 26 μ g/I) They remained low for the first week (days 4 and 7, 109 ±16 μg/I), then increased to reach normal values at the end of the study period (days 10–16,144 ± 19 μg/l, P= 0 005 when compared to days 4–7; days 19–25, 206 ±30 μg/l, P= 0 008 when compared to days 10–16). IGF-I levels were negatively correlated with age in the second phase of recovery only (days 10–16, r= -0–70, P<005; days 19–25, r= -0 75, P<0 01) and with severity of burn between days 19 and 25 (r= -0 62, P<0 05). The presence of bronchial burn injury tended to lower IGF-I blood concentration (P= 0 08). Whereas IGF-I concentrations increased in the later phase of recovery, nitrogen balances did not. As a result, there was no significant correlation between these parameters. CONCLUSIONS IGF-I levels followed a biphasic pattern in severely burned patients. They dropped dramatically in response to the traumatic shock, then increased during recovery. The degree of increase was dependent on the age of the patient and on the severity of the burn, but was not associated with an improvement in the nitrogen balance." @default.
• W2047582990 created "2016-06-24" @default.
• W2047582990 creator A5004087382 @default.
• W2047582990 creator A5021146466 @default.
• W2047582990 creator A5026545871 @default.
• W2047582990 creator A5068514532 @default.
• W2047582990 date "1993-11-01" @default.
• W2047582990 modified "2023-09-30" @default.
• W2047582990 title "Insulin-like growth factor-l blood levels in severely burned patients: effects of time post injury, age of patient and severity of burn" @default.
• W2047582990 cites W182030077 @default.
• W2047582990 cites W1868177001 @default.
• W2047582990 cites W1975667857 @default.
• W2047582990 cites W1979251815 @default.
• W2047582990 cites W1979765112 @default.
• W2047582990 cites W1986111722 @default.
• W2047582990 cites W1997907168 @default.
• W2047582990 cites W2006393438 @default.
• W2047582990 cites W2011337242 @default.
• W2047582990 cites W2014924964 @default.
• W2047582990 cites W2024067973 @default.
• W2047582990 cites W2025652877 @default.
• W2047582990 cites W2032301332 @default.
• W2047582990 cites W2037737006 @default.
• W2047582990 cites W2059156857 @default.
• W2047582990 cites W2066114232 @default.
• W2047582990 cites W2067928350 @default.
• W2047582990 cites W2067960281 @default.
• W2047582990 cites W2075919355 @default.
• W2047582990 cites W2161763667 @default.
• W2047582990 cites W2404809414 @default.
• W2047582990 cites W3142396489 @default.
• W2047582990 cites W4205415640 @default.
• W2047582990 cites W4235346983 @default.
• W2047582990 cites W4236405229 @default.
• W2047582990 doi "https://doi.org/10.1111/j.1365-2265.1993.tb02413.x" @default.
• W2047582990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8252749" @default.
• W2047582990 hasPublicationYear "1993" @default.
• W2047582990 type Work @default.
• W2047582990 sameAs 2047582990 @default.
• W2047582990 citedByCount "64" @default.
• W2047582990 countsByYear W20475829902012 @default.
• W2047582990 countsByYear W20475829902015 @default.
• W2047582990 countsByYear W20475829902017 @default.
• W2047582990 countsByYear W20475829902018 @default.
• W2047582990 countsByYear W20475829902020 @default.
• W2047582990 crossrefType "journal-article" @default.
• W2047582990 hasAuthorship W2047582990A5004087382 @default.
• W2047582990 hasAuthorship W2047582990A5021146466 @default.
• W2047582990 hasAuthorship W2047582990A5026545871 @default.
• W2047582990 hasAuthorship W2047582990A5068514532 @default.
• W2047582990 hasConcept C126322002 @default.
• W2047582990 hasConcept C134018914 @default.
• W2047582990 hasConcept C141071460 @default.
• W2047582990 hasConcept C170493617 @default.
• W2047582990 hasConcept C176685330 @default.
• W2047582990 hasConcept C2775960820 @default.
• W2047582990 hasConcept C2779306644 @default.
• W2047582990 hasConcept C2780689927 @default.
• W2047582990 hasConcept C2908647359 @default.
• W2047582990 hasConcept C2993242423 @default.
• W2047582990 hasConcept C71924100 @default.
• W2047582990 hasConcept C99454951 @default.
• W2047582990 hasConceptScore W2047582990C126322002 @default.
• W2047582990 hasConceptScore W2047582990C134018914 @default.
• W2047582990 hasConceptScore W2047582990C141071460 @default.
• W2047582990 hasConceptScore W2047582990C170493617 @default.
• W2047582990 hasConceptScore W2047582990C176685330 @default.
• W2047582990 hasConceptScore W2047582990C2775960820 @default.
• W2047582990 hasConceptScore W2047582990C2779306644 @default.
• W2047582990 hasConceptScore W2047582990C2780689927 @default.
• W2047582990 hasConceptScore W2047582990C2908647359 @default.
• W2047582990 hasConceptScore W2047582990C2993242423 @default.
• W2047582990 hasConceptScore W2047582990C71924100 @default.
• W2047582990 hasConceptScore W2047582990C99454951 @default.
• W2047582990 hasIssue "5" @default.
• W2047582990 hasLocation W20475829901 @default.
• W2047582990 hasLocation W20475829902 @default.
• W2047582990 hasOpenAccess W2047582990 @default.
• W2047582990 hasPrimaryLocation W20475829901 @default.
• W2047582990 hasRelatedWork W1989449228 @default.
• W2047582990 hasRelatedWork W2010140898 @default.
• W2047582990 hasRelatedWork W2068266933 @default.
• W2047582990 hasRelatedWork W2072014172 @default.
• W2047582990 hasRelatedWork W2089518257 @default.
• W2047582990 hasRelatedWork W2098742882 @default.
• W2047582990 hasRelatedWork W2103096725 @default.
• W2047582990 hasRelatedWork W4234612679 @default.
• W2047582990 hasRelatedWork W4236502113 @default.
• W2047582990 hasRelatedWork W4255621366 @default.
• W2047582990 hasVolume "39" @default.
• W2047582990 isParatext "false" @default.
• W2047582990 isRetracted "false" @default.
• W2047582990 magId "2047582990" @default.
• W2047582990 workType "article" @default.