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- W2047584246 abstract "A new rapid analytical method is applied for water determination in alpha-Mono-thioglycerol and Captopril tablets containing thiols, and therefore, not amenable for direct Karl Fischer titration. The method is based on the consecutive titration first of thiol by a novel reagent, and then of water by a conventional K. Fischer reagent in the same sample and cell with the electrometric 'dead-stop' location of the end point in both titrations. The new reagent consists of iodine, potassium iodide and sodium acetate in non-aqueous medium. Estimated repeatability and accuracy of both water and thiol determinations are satisfactory." @default.
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- W2047584246 date "1999-11-01" @default.
- W2047584246 modified "2023-09-27" @default.
- W2047584246 title "Water determination in drugs containing thiols" @default.
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- W2047584246 doi "https://doi.org/10.1016/s0378-5173(99)00290-2" @default.
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