FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047589406> ?p ?o ?g. }

• W2047589406 abstract "As a component of the enzyme glutathione peroxidase, the essential trace element selenium contributes to the reduction of peroxides. Disturbed selenium availability may relate to an activated immune response. In humans, immune activation is reflected by increased neopterin production and accelerated tryptophan degradation, expressed as the kynurenine to tryptophan ratio (kyn/trp). Th1-type cytokine interferon-gamma induces both these immunobiological events in human macrophages and they are often activated in patients with cardiac disorders. The aim of this study was to determine the relationship between serum selenium concentrations and neopterin production and tryptophan degradation in patients with cardiac disorders.In 56 patients (28 females) with cardiac disorders, serum selenium concentrations were determined by graphite-furnace atomic absorption spectrometry. Serum neopterin concentration was measured by ELISA and tryptophan degradation was examined by HPLC.Selenium concentrations were in the range 0.41-1.90 micromol/L (median 1.02) and were well within the local normal range. Approximately two-thirds of patients presented with higher neopterin concentrations (median 16.4 nmol/L) and tryptophan degradation (median 57 micromol/mmol kyn/trp). There was an inverse correlation between serum selenium and kyn/trp (Spearman's rank correlation, r(s)=-0.431; p<0.001) and neopterin concentrations (r(s)=-0.300; p<0.05). Neopterin concentrations correlated strongly with kyn/trp (r(s)=0.712; p<0.0001).A higher degree of tryptophan degradation and of neopterin production in patients with cardiac disorders coincides with lower, albeit still normal, serum selenium concentrations. Data show that in these patients immune activation is associated with lower serum selenium concentrations." @default.
• W2047589406 created "2016-06-24" @default.
• W2047589406 creator A5008313136 @default.
• W2047589406 creator A5012917581 @default.
• W2047589406 creator A5019144319 @default.
• W2047589406 creator A5035954114 @default.
• W2047589406 creator A5055193163 @default.
• W2047589406 creator A5066705591 @default.
• W2047589406 creator A5081156604 @default.
• W2047589406 date "2007-01-01" @default.
• W2047589406 modified "2023-09-23" @default.
• W2047589406 title "Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders" @default.
• W2047589406 cites W1627869463 @default.
• W2047589406 cites W1834981029 @default.
• W2047589406 cites W18405201 @default.
• W2047589406 cites W1863865360 @default.
• W2047589406 cites W1925988920 @default.
• W2047589406 cites W1963311479 @default.
• W2047589406 cites W1964632509 @default.
• W2047589406 cites W1968143482 @default.
• W2047589406 cites W1985046186 @default.
• W2047589406 cites W2003476696 @default.
• W2047589406 cites W2019668721 @default.
• W2047589406 cites W2020589313 @default.
• W2047589406 cites W2022430924 @default.
• W2047589406 cites W2022481955 @default.
• W2047589406 cites W2026682916 @default.
• W2047589406 cites W2026759435 @default.
• W2047589406 cites W2026803942 @default.
• W2047589406 cites W203462452 @default.
• W2047589406 cites W2041382001 @default.
• W2047589406 cites W2041781489 @default.
• W2047589406 cites W2042641359 @default.
• W2047589406 cites W2047101702 @default.
• W2047589406 cites W2056039391 @default.
• W2047589406 cites W2069378726 @default.
• W2047589406 cites W2071922368 @default.
• W2047589406 cites W2111926934 @default.
• W2047589406 cites W2130438142 @default.
• W2047589406 cites W2138122208 @default.
• W2047589406 cites W2159087408 @default.
• W2047589406 cites W2160040629 @default.
• W2047589406 cites W2165233139 @default.
• W2047589406 cites W2260229005 @default.
• W2047589406 cites W2316938069 @default.
• W2047589406 cites W2405366220 @default.
• W2047589406 doi "https://doi.org/10.1515/cclm.2007.264" @default.
• W2047589406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17635079" @default.
• W2047589406 hasPublicationYear "2007" @default.
• W2047589406 type Work @default.
• W2047589406 sameAs 2047589406 @default.
• W2047589406 citedByCount "12" @default.
• W2047589406 countsByYear W20475894062012 @default.
• W2047589406 countsByYear W20475894062015 @default.
• W2047589406 countsByYear W20475894062018 @default.
• W2047589406 countsByYear W20475894062020 @default.
• W2047589406 countsByYear W20475894062021 @default.
• W2047589406 crossrefType "journal-article" @default.
• W2047589406 hasAuthorship W2047589406A5008313136 @default.
• W2047589406 hasAuthorship W2047589406A5012917581 @default.
• W2047589406 hasAuthorship W2047589406A5019144319 @default.
• W2047589406 hasAuthorship W2047589406A5035954114 @default.
• W2047589406 hasAuthorship W2047589406A5055193163 @default.
• W2047589406 hasAuthorship W2047589406A5066705591 @default.
• W2047589406 hasAuthorship W2047589406A5081156604 @default.
• W2047589406 hasConcept C126322002 @default.
• W2047589406 hasConcept C134018914 @default.
• W2047589406 hasConcept C178790620 @default.
• W2047589406 hasConcept C185592680 @default.
• W2047589406 hasConcept C203014093 @default.
• W2047589406 hasConcept C2776603314 @default.
• W2047589406 hasConcept C2776706248 @default.
• W2047589406 hasConcept C2777503454 @default.
• W2047589406 hasConcept C515207424 @default.
• W2047589406 hasConcept C553756173 @default.
• W2047589406 hasConcept C55493867 @default.
• W2047589406 hasConcept C71924100 @default.
• W2047589406 hasConcept C8891405 @default.
• W2047589406 hasConceptScore W2047589406C126322002 @default.
• W2047589406 hasConceptScore W2047589406C134018914 @default.
• W2047589406 hasConceptScore W2047589406C178790620 @default.
• W2047589406 hasConceptScore W2047589406C185592680 @default.
• W2047589406 hasConceptScore W2047589406C203014093 @default.
• W2047589406 hasConceptScore W2047589406C2776603314 @default.
• W2047589406 hasConceptScore W2047589406C2776706248 @default.
• W2047589406 hasConceptScore W2047589406C2777503454 @default.
• W2047589406 hasConceptScore W2047589406C515207424 @default.
• W2047589406 hasConceptScore W2047589406C553756173 @default.
• W2047589406 hasConceptScore W2047589406C55493867 @default.
• W2047589406 hasConceptScore W2047589406C71924100 @default.
• W2047589406 hasConceptScore W2047589406C8891405 @default.
• W2047589406 hasLocation W20475894061 @default.
• W2047589406 hasLocation W20475894062 @default.
• W2047589406 hasOpenAccess W2047589406 @default.
• W2047589406 hasPrimaryLocation W20475894061 @default.
• W2047589406 hasRelatedWork W1553983160 @default.
• W2047589406 hasRelatedWork W1978992242 @default.
• W2047589406 hasRelatedWork W2024939871 @default.
• W2047589406 hasRelatedWork W2025593248 @default.
• W2047589406 hasRelatedWork W2034242699 @default.

• next