FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W204761496> ?p ?o ?g. }

• W204761496 endingPage "44" @default.
• W204761496 startingPage "38" @default.
• W204761496 abstract "Abstract In 20 patients with acute myocardial infarction (AMI) treated with streptokinase (SK, n = 7), recombinant single-chain tissue plasminogen activator (rt-PA, n = 7) or urokinase (UK, n = 6), the behavior of plasma von Willebrand factor (vWF) was studied before and 1.5, 3, 24, 48, and 72 hours after beginning thrombolytic therapy. vWF antigen (vWF:Ag) was high in plasma, especially after SK. The ristocetin cofactor (RiCof) activity of vWF, high before therapy, tended to decrease soon after therapy. This pattern of vWF changes was paralleled by the early loss of higher molecular weight multimers. By immunoblotting of immunopurified and reduced vWF and monoclonal antibody epitope mapping, we found that vWF was degraded after thrombolysis, especially after SK, as indicated by the higher values of two plasmin-generated fragments of 176 and 145 Kd. There were more plasmin-generated fragments in the five patients who had bleeding complications than in the remaining 15 who did not. In conclusion, quantitative and qualitative changes of vWF compatible with proteolytic degradation of the protein occur during thrombolytic therapy. Such degradation, roughly proportional to the degree of the general lytic state induced by each agent, might be a cofactor of the bleeding complications occurring in treated patients." @default.
• W204761496 created "2016-06-24" @default.
• W204761496 creator A5008136405 @default.
• W204761496 creator A5055052720 @default.
• W204761496 creator A5059596200 @default.
• W204761496 creator A5065489740 @default.
• W204761496 date "1992-01-01" @default.
• W204761496 modified "2023-09-27" @default.
• W204761496 title "Proteolysis of von Willebrand factor after thrombolytic therapy in patients with acute myocardial infarction" @default.
• W204761496 cites W1504674459 @default.
• W204761496 cites W1965404104 @default.
• W204761496 cites W1976972736 @default.
• W204761496 cites W1981603838 @default.
• W204761496 cites W2001563266 @default.
• W204761496 cites W2012124471 @default.
• W204761496 cites W2015900829 @default.
• W204761496 cites W2075333817 @default.
• W204761496 cites W2076958252 @default.
• W204761496 cites W2088562551 @default.
• W204761496 cites W2090372899 @default.
• W204761496 cites W2100837269 @default.
• W204761496 cites W2105727676 @default.
• W204761496 cites W2160883455 @default.
• W204761496 cites W2409338767 @default.
• W204761496 cites W2418876141 @default.
• W204761496 cites W2421170353 @default.
• W204761496 cites W2422606642 @default.
• W204761496 cites W2463922980 @default.
• W204761496 cites W2587921958 @default.
• W204761496 cites W303904845 @default.
• W204761496 cites W3113274326 @default.
• W204761496 cites W324903366 @default.
• W204761496 cites W38916664 @default.
• W204761496 cites W767461125 @default.
• W204761496 cites W3194676096 @default.
• W204761496 doi "https://doi.org/10.1182/blood.v79.1.38.38" @default.
• W204761496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1530813" @default.
• W204761496 hasPublicationYear "1992" @default.
• W204761496 type Work @default.
• W204761496 sameAs 204761496 @default.
• W204761496 citedByCount "40" @default.
• W204761496 countsByYear W2047614962012 @default.
• W204761496 countsByYear W2047614962013 @default.
• W204761496 countsByYear W2047614962015 @default.
• W204761496 countsByYear W2047614962016 @default.
• W204761496 countsByYear W2047614962017 @default.
• W204761496 countsByYear W2047614962018 @default.
• W204761496 countsByYear W2047614962020 @default.
• W204761496 countsByYear W2047614962021 @default.
• W204761496 crossrefType "journal-article" @default.
• W204761496 hasAuthorship W204761496A5008136405 @default.
• W204761496 hasAuthorship W204761496A5055052720 @default.
• W204761496 hasAuthorship W204761496A5059596200 @default.
• W204761496 hasAuthorship W204761496A5065489740 @default.
• W204761496 hasBestOaLocation W2047614961 @default.
• W204761496 hasConcept C126322002 @default.
• W204761496 hasConcept C134018914 @default.
• W204761496 hasConcept C181199279 @default.
• W204761496 hasConcept C185592680 @default.
• W204761496 hasConcept C203014093 @default.
• W204761496 hasConcept C2776336681 @default.
• W204761496 hasConcept C2776825266 @default.
• W204761496 hasConcept C2776892390 @default.
• W204761496 hasConcept C2779394231 @default.
• W204761496 hasConcept C2779581417 @default.
• W204761496 hasConcept C2779679481 @default.
• W204761496 hasConcept C2779936836 @default.
• W204761496 hasConcept C2781071845 @default.
• W204761496 hasConcept C500558357 @default.
• W204761496 hasConcept C55493867 @default.
• W204761496 hasConcept C71924100 @default.
• W204761496 hasConcept C89560881 @default.
• W204761496 hasConcept C90924648 @default.
• W204761496 hasConceptScore W204761496C126322002 @default.
• W204761496 hasConceptScore W204761496C134018914 @default.
• W204761496 hasConceptScore W204761496C181199279 @default.
• W204761496 hasConceptScore W204761496C185592680 @default.
• W204761496 hasConceptScore W204761496C203014093 @default.
• W204761496 hasConceptScore W204761496C2776336681 @default.
• W204761496 hasConceptScore W204761496C2776825266 @default.
• W204761496 hasConceptScore W204761496C2776892390 @default.
• W204761496 hasConceptScore W204761496C2779394231 @default.
• W204761496 hasConceptScore W204761496C2779581417 @default.
• W204761496 hasConceptScore W204761496C2779679481 @default.
• W204761496 hasConceptScore W204761496C2779936836 @default.
• W204761496 hasConceptScore W204761496C2781071845 @default.
• W204761496 hasConceptScore W204761496C500558357 @default.
• W204761496 hasConceptScore W204761496C55493867 @default.
• W204761496 hasConceptScore W204761496C71924100 @default.
• W204761496 hasConceptScore W204761496C89560881 @default.
• W204761496 hasConceptScore W204761496C90924648 @default.
• W204761496 hasIssue "1" @default.
• W204761496 hasLocation W2047614961 @default.
• W204761496 hasOpenAccess W204761496 @default.
• W204761496 hasPrimaryLocation W2047614961 @default.
• W204761496 hasRelatedWork W1580336555 @default.
• W204761496 hasRelatedWork W2022609772 @default.
• W204761496 hasRelatedWork W2073978137 @default.

• next