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• W2047625632 abstract "Molecular models of cell fate specification typically focus on the activation of specific lineage programs. However, the concurrent repression of unwanted transcriptional networks is also essential to stabilize certain cellular identities, as shown in a number of diverse systems and phyla. Here, we demonstrate that this dual requirement also holds true in the context of Drosophila myogenesis. By integrating genetics and genomics, we identified a new role for the pleiotropic transcriptional repressor Tramtrack69 in myoblast specification. Drosophila muscles are formed through the fusion of two discrete cell types: founder cells (FCs) and fusion-competent myoblasts (FCMs). When tramtrack69 is removed, FCMs appear to adopt an alternative muscle FC-like fate. Conversely, ectopic expression of this repressor phenocopies muscle defects seen in loss-of-function lame duck mutants, a transcription factor specific to FCMs. This occurs through Tramtrack69-mediated repression in FCMs, whereas Lame duck activates a largely distinct transcriptional program in the same cells. Lineage-specific factors are therefore not sufficient to maintain FCM identity. Instead, their identity appears more plastic, requiring the combination of instructive repressive and activating programs to stabilize cell fate." @default.
• W2047625632 created "2016-06-24" @default.
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• W2047625632 date "2014-07-01" @default.
• W2047625632 modified "2023-10-14" @default.
• W2047625632 title "Coordinated repression and activation of two transcriptional programs stabilizes cell fate during myogenesis" @default.
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• W2047625632 cites W1950932417 @default.
• W2047625632 cites W1965824945 @default.
• W2047625632 cites W1968465765 @default.
• W2047625632 cites W1970986954 @default.
• W2047625632 cites W1974331467 @default.
• W2047625632 cites W1977620504 @default.
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• W2047625632 doi "https://doi.org/10.1242/dev.101956" @default.
• W2047625632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146391" @default.
• W2047625632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24961800" @default.
• W2047625632 hasPublicationYear "2014" @default.
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