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- W2047631021 abstract "Lamina propria T lymphocytes (LPL-T) have a low proliferative potential in vitro. We asked whether LPL-T are also hyporesponsive in vivo and whether this is specific for the αβ T cell receptor (TCR). Mitogenic mAb directed at the αβ TCR, CD2, CD28, or control mAbs plus IL-2 were injected into rats. Proliferation and/or apoptosis were detected by double staining using 5-bromo-2′-deoxyuridine/TUNEL and the αβ TCR. LPL-T were hyporesponsive to various stimuli compared to other T cells. The strongest proliferation was found upon CD2/CD28 stimulation (LPL-T: 281 ± 6%; spleen: 642 ± 31%). LPL-T proliferation was only detectable at 24 h while proliferation in other compartments also occurred later. Hyporesponsiveness was not caused by enhanced T cell apoptosis upon αβ TCR stimulation. In conclusion, stimulation of LPL-T results in much shorter and weaker in vivo proliferation than in other lymphoid organs. Overall, CD2/CD28 costimulation is the strongest T cell stimulus in vivo." @default.
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- W2047631021 date "2009-01-01" @default.
- W2047631021 modified "2023-10-17" @default.
- W2047631021 title "In vivoProliferation of Rat Lamina Propria T Lymphocytes: General Hyporesponsiveness but Increased Importance of the CD2 and CD28 Pathways" @default.
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- W2047631021 doi "https://doi.org/10.1080/08820130902888342" @default.
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