FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047657908> ?p ?o ?g. }

• W2047657908 endingPage "304" @default.
• W2047657908 startingPage "294" @default.
• W2047657908 abstract "TRAIL/Apo-2L has shown promise as an anti-glioma drug, based on investigations of TRAIL sensitivity in established glioma cell lines, but it is not known how accurately TRAIL signalling pathways of glioma cells in vivo are reproduced in these cell lines in vitro. To replicate as closely as possible the in vivo behaviour of malignant glioma cells, 17 early passage glioma cell lines and 5 freshly resected gliomas were exposed to TRAIL-based agents and/or chemotherapeutic drugs. Normal human hepatocytes and astrocytes and established glioma cell lines were also tested. Cross-linked TRAIL, but not soluble TRAIL, killed both normal cell types and cells from three tumours. Cells from only one glioma were killed by soluble TRAIL, although only inefficiently. High concentrations of cisplatin were lethal to glioma cells, hepatocytes and astrocytes. Isolated combinations of TRAIL and chemotherapy drugs were more toxic to particular gliomas than normal cells, but no combination was generally selective for glioma cells. This study highlights the widespread resistance of glioma cells to TRAIL-based agents, but suggests that a minority of high-grade glioma patients may benefit from particular combinations of TRAIL and chemotherapy drugs. In vitro sensitivity assays may help identify effective drug combinations for individual glioma patients." @default.
• W2047657908 created "2016-06-24" @default.
• W2047657908 creator A5000265791 @default.
• W2047657908 creator A5002823066 @default.
• W2047657908 creator A5010378038 @default.
• W2047657908 creator A5012993050 @default.
• W2047657908 creator A5020954253 @default.
• W2047657908 creator A5022581320 @default.
• W2047657908 creator A5043393389 @default.
• W2047657908 creator A5046373006 @default.
• W2047657908 creator A5054088397 @default.
• W2047657908 creator A5057371623 @default.
• W2047657908 creator A5060696449 @default.
• W2047657908 creator A5072367815 @default.
• W2047657908 date "2008-07-01" @default.
• W2047657908 modified "2023-10-15" @default.
• W2047657908 title "In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs" @default.
• W2047657908 cites W1483659927 @default.
• W2047657908 cites W1599806854 @default.
• W2047657908 cites W1836073275 @default.
• W2047657908 cites W1966270249 @default.
• W2047657908 cites W1966334119 @default.
• W2047657908 cites W1967637444 @default.
• W2047657908 cites W1972977802 @default.
• W2047657908 cites W1973087709 @default.
• W2047657908 cites W1973109581 @default.
• W2047657908 cites W1973873084 @default.
• W2047657908 cites W1976917719 @default.
• W2047657908 cites W1977748264 @default.
• W2047657908 cites W1983730183 @default.
• W2047657908 cites W1997349871 @default.
• W2047657908 cites W2000201916 @default.
• W2047657908 cites W2002987782 @default.
• W2047657908 cites W2010559666 @default.
• W2047657908 cites W2012880829 @default.
• W2047657908 cites W2013993442 @default.
• W2047657908 cites W2014380713 @default.
• W2047657908 cites W2014433632 @default.
• W2047657908 cites W2018671779 @default.
• W2047657908 cites W2023187070 @default.
• W2047657908 cites W2026057304 @default.
• W2047657908 cites W2026865369 @default.
• W2047657908 cites W2028253079 @default.
• W2047657908 cites W2028568188 @default.
• W2047657908 cites W2031803938 @default.
• W2047657908 cites W2033346155 @default.
• W2047657908 cites W2042502679 @default.
• W2047657908 cites W2043754322 @default.
• W2047657908 cites W2054717287 @default.
• W2047657908 cites W2055905844 @default.
• W2047657908 cites W2062214897 @default.
• W2047657908 cites W2063863812 @default.
• W2047657908 cites W2076152655 @default.
• W2047657908 cites W2079455219 @default.
• W2047657908 cites W2084733813 @default.
• W2047657908 cites W2092191811 @default.
• W2047657908 cites W2096287682 @default.
• W2047657908 cites W2102349540 @default.
• W2047657908 cites W2106284224 @default.
• W2047657908 cites W2108902725 @default.
• W2047657908 cites W2116595455 @default.
• W2047657908 cites W2119326933 @default.
• W2047657908 cites W2139008103 @default.
• W2047657908 cites W2148684210 @default.
• W2047657908 cites W2158757928 @default.
• W2047657908 cites W2162275000 @default.
• W2047657908 cites W2162749413 @default.
• W2047657908 cites W2169103384 @default.
• W2047657908 cites W2314104762 @default.
• W2047657908 cites W2315658233 @default.
• W2047657908 cites W2320870975 @default.
• W2047657908 doi "https://doi.org/10.1038/sj.bjc.6604459" @default.
• W2047657908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661787" @default.
• W2047657908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18594532" @default.
• W2047657908 hasPublicationYear "2008" @default.
• W2047657908 type Work @default.
• W2047657908 sameAs 2047657908 @default.
• W2047657908 citedByCount "16" @default.
• W2047657908 countsByYear W20476579082012 @default.
• W2047657908 countsByYear W20476579082013 @default.
• W2047657908 countsByYear W20476579082014 @default.
• W2047657908 countsByYear W20476579082017 @default.
• W2047657908 countsByYear W20476579082020 @default.
• W2047657908 countsByYear W20476579082022 @default.
• W2047657908 crossrefType "journal-article" @default.
• W2047657908 hasAuthorship W2047657908A5000265791 @default.
• W2047657908 hasAuthorship W2047657908A5002823066 @default.
• W2047657908 hasAuthorship W2047657908A5010378038 @default.
• W2047657908 hasAuthorship W2047657908A5012993050 @default.
• W2047657908 hasAuthorship W2047657908A5020954253 @default.
• W2047657908 hasAuthorship W2047657908A5022581320 @default.
• W2047657908 hasAuthorship W2047657908A5043393389 @default.
• W2047657908 hasAuthorship W2047657908A5046373006 @default.
• W2047657908 hasAuthorship W2047657908A5054088397 @default.
• W2047657908 hasAuthorship W2047657908A5057371623 @default.
• W2047657908 hasAuthorship W2047657908A5060696449 @default.
• W2047657908 hasAuthorship W2047657908A5072367815 @default.
• W2047657908 hasBestOaLocation W20476579081 @default.

• next