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- W2047682708 abstract "Bioisosteric replacements were accomplished by building the structural elements of piroxicam, an anti-inflammatory drug, into the pentacyclic system of rutaecarpine, a quinazolinocarboline alkaloid, in order to modify activity and selectivity on COX-isoenzymes. The pentacyclic compounds were synthesized efficiently by employing 1-oxo-9,10,11,12-tetrahydro-4H-pyrido[1,2-b]1,2-benzothiazine 5,5-dioxide as a key intermediate, and prepared by alternative routes. Condensation of the tricyclic ketone with arylhydrazines and subsequent Fischer-indolization provided the first representatives of new heterocyclic ring systems 3 and 4." @default.
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- W2047682708 date "2008-09-01" @default.
- W2047682708 modified "2023-10-18" @default.
- W2047682708 title "Bioisosteric hybrids of two anti-inflammatory agents, rutaecarpine and piroxicam" @default.
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- W2047682708 doi "https://doi.org/10.1016/j.tetlet.2008.07.098" @default.
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