FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047685110> ?p ?o ?g. }

• W2047685110 endingPage "2434" @default.
• W2047685110 startingPage "2427" @default.
• W2047685110 abstract "PEDF (pigment epithelium-derived factor) promotes the differentiation and survival of neuronal cells, and expands the adult neuronal stem cell niche. In the prostate PEDF is suppressed by androgen with unclear physiological consequences. We report that PEDF induced the neuroendocrine differentiation of prostate cancer cells, which was accompanied by neurite outgrowth and chromogranin A expression.We performed neuroendocrine differentiation assay, Western blot analysis, immunostaining and reverse transcriptase-polymerase chain reaction in the human prostate cancer cell lines LNCaP, PC-3 and DU145, and the prostate epithelial strain RWPE-1 (ATCC).Ectopic and endogenous PEDF caused neuroendocrine differentiation of prostate cancer cells, as manifested by neurite-like outgrowths and chromogranin A expression. The transdifferentiated cells expressed axonal and dendritic markers, as ascertained by immunoblotting for specific markers. Neuroendocrine cells formed multiple synaptophysin positive protrusions resembling dendritic spines and vesicles containing serotonin, pointing to possible synapse formation. The known transdifferentiating agent interleukin-6 induced PEDF secretion. Moreover, PEDF neutralizing antibodies abolished the transdifferentiation of interleukin-6 treated cells, suggesting an autocrine loop. Neurogenic events were independent of cyclic adenosine monophosphate. Instead, PEDF activated in this order RhoA, nuclear factor kappaB and Stat3. Inhibitors of the Rho, nuclear factor kappaB and STAT pathways abolished differentiation and synapse formation. Additionally, nuclear factor kappaB activation caused interleukin-6 expression.We discovered that nuclear factor kappaB controls the formation of neuronal communications in the prostate due to PEDF. We defined a feed-forward loop, in which nuclear factor kappaB induction elicits Stat3 activation and pro-differentiating interleukin-6 expression causes the further expansion of neuroendocrine communications. Our findings point to the role of nuclear factor kappaB and PEDF in coordinated prostate development." @default.
• W2047685110 created "2016-06-24" @default.
• W2047685110 creator A5002277031 @default.
• W2047685110 creator A5017190205 @default.
• W2047685110 creator A5019822971 @default.
• W2047685110 creator A5036397551 @default.
• W2047685110 creator A5043772466 @default.
• W2047685110 creator A5051320738 @default.
• W2047685110 creator A5058251204 @default.
• W2047685110 creator A5089397657 @default.
• W2047685110 date "2008-06-01" @default.
• W2047685110 modified "2023-09-25" @default.
• W2047685110 title "Pigment Epithelium-Derived Factor and Interleukin-6 Control Prostate Neuroendocrine Differentiation via Feed-Forward Mechanism" @default.
• W2047685110 cites W1571229160 @default.
• W2047685110 cites W1976897228 @default.
• W2047685110 cites W1977389640 @default.
• W2047685110 cites W1999642875 @default.
• W2047685110 cites W2011663673 @default.
• W2047685110 cites W2043609102 @default.
• W2047685110 cites W2046063243 @default.
• W2047685110 cites W2046234516 @default.
• W2047685110 cites W2047265695 @default.
• W2047685110 cites W2059890547 @default.
• W2047685110 cites W2069665674 @default.
• W2047685110 cites W2077041282 @default.
• W2047685110 cites W2105103391 @default.
• W2047685110 cites W2123898255 @default.
• W2047685110 cites W2137958038 @default.
• W2047685110 cites W2139159830 @default.
• W2047685110 cites W2140509267 @default.
• W2047685110 cites W2157976596 @default.
• W2047685110 cites W4243066396 @default.
• W2047685110 cites W4248286954 @default.
• W2047685110 doi "https://doi.org/10.1016/j.juro.2008.01.081" @default.
• W2047685110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2849797" @default.
• W2047685110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18433784" @default.
• W2047685110 hasPublicationYear "2008" @default.
• W2047685110 type Work @default.
• W2047685110 sameAs 2047685110 @default.
• W2047685110 citedByCount "26" @default.
• W2047685110 countsByYear W20476851102013 @default.
• W2047685110 countsByYear W20476851102014 @default.
• W2047685110 countsByYear W20476851102015 @default.
• W2047685110 countsByYear W20476851102016 @default.
• W2047685110 countsByYear W20476851102017 @default.
• W2047685110 countsByYear W20476851102018 @default.
• W2047685110 countsByYear W20476851102019 @default.
• W2047685110 countsByYear W20476851102021 @default.
• W2047685110 crossrefType "journal-article" @default.
• W2047685110 hasAuthorship W2047685110A5002277031 @default.
• W2047685110 hasAuthorship W2047685110A5017190205 @default.
• W2047685110 hasAuthorship W2047685110A5019822971 @default.
• W2047685110 hasAuthorship W2047685110A5036397551 @default.
• W2047685110 hasAuthorship W2047685110A5043772466 @default.
• W2047685110 hasAuthorship W2047685110A5051320738 @default.
• W2047685110 hasAuthorship W2047685110A5058251204 @default.
• W2047685110 hasAuthorship W2047685110A5089397657 @default.
• W2047685110 hasBestOaLocation W20476851102 @default.
• W2047685110 hasConcept C104317684 @default.
• W2047685110 hasConcept C113246987 @default.
• W2047685110 hasConcept C121608353 @default.
• W2047685110 hasConcept C126322002 @default.
• W2047685110 hasConcept C128240485 @default.
• W2047685110 hasConcept C134018914 @default.
• W2047685110 hasConcept C148738053 @default.
• W2047685110 hasConcept C202751555 @default.
• W2047685110 hasConcept C203014093 @default.
• W2047685110 hasConcept C204232928 @default.
• W2047685110 hasConcept C2776235491 @default.
• W2047685110 hasConcept C2776438761 @default.
• W2047685110 hasConcept C2779723316 @default.
• W2047685110 hasConcept C2780192828 @default.
• W2047685110 hasConcept C2780341458 @default.
• W2047685110 hasConcept C2780394083 @default.
• W2047685110 hasConcept C28328180 @default.
• W2047685110 hasConcept C502942594 @default.
• W2047685110 hasConcept C52237779 @default.
• W2047685110 hasConcept C54355233 @default.
• W2047685110 hasConcept C55493867 @default.
• W2047685110 hasConcept C60870556 @default.
• W2047685110 hasConcept C71924100 @default.
• W2047685110 hasConcept C77231918 @default.
• W2047685110 hasConcept C81885089 @default.
• W2047685110 hasConcept C86803240 @default.
• W2047685110 hasConcept C95444343 @default.
• W2047685110 hasConceptScore W2047685110C104317684 @default.
• W2047685110 hasConceptScore W2047685110C113246987 @default.
• W2047685110 hasConceptScore W2047685110C121608353 @default.
• W2047685110 hasConceptScore W2047685110C126322002 @default.
• W2047685110 hasConceptScore W2047685110C128240485 @default.
• W2047685110 hasConceptScore W2047685110C134018914 @default.
• W2047685110 hasConceptScore W2047685110C148738053 @default.
• W2047685110 hasConceptScore W2047685110C202751555 @default.
• W2047685110 hasConceptScore W2047685110C203014093 @default.
• W2047685110 hasConceptScore W2047685110C204232928 @default.
• W2047685110 hasConceptScore W2047685110C2776235491 @default.
• W2047685110 hasConceptScore W2047685110C2776438761 @default.
• W2047685110 hasConceptScore W2047685110C2779723316 @default.

• next