Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047707320> ?p ?o ?g. }
- W2047707320 endingPage "132" @default.
- W2047707320 startingPage "126" @default.
- W2047707320 abstract "The 4E-binding proteins (4E-BPs) regulate the cap-dependent eukaryotic initiation factor 4E (eIF4E). The level of 4E-BP protein is regulated during early development of sea urchin embryos. Fertilization leads to the rapid disappearance of the protein that reappears later in development. We show that two important cellular stresses, hypoxia and bleomycin prolonged checkpoint mobilization provoked the overexpression of the protein 4E-BP in developing sea urchin embryos. Hypoxia resulted after 1 h in a reversible gradual increase in the protein 4E-BP level. At 20 h, the protein 4E-BP had reached the level existing in the unfertilized eggs. Bleomycin used as a DNA-damaging agent for checkpoint activation, provoked cell cycle inhibition and after prolonged exposure (20 h), induced the expression of the protein 4E-BP. The effect of bleomycin on 4E-BP protein overexpression was dose-dependent between 0.4 and 1.2 mM. The role of the overexpression of the protein 4E-BP is discussed in relation with cellular stress responses." @default.
- W2047707320 created "2016-06-24" @default.
- W2047707320 creator A5014458386 @default.
- W2047707320 creator A5051231551 @default.
- W2047707320 creator A5072525622 @default.
- W2047707320 creator A5083316914 @default.
- W2047707320 date "2006-04-05" @default.
- W2047707320 modified "2023-10-10" @default.
- W2047707320 title "Hypoxia and DNA-damaging agent bleomycin both increase the cellular level of the protein 4E-BP" @default.
- W2047707320 cites W1479769602 @default.
- W2047707320 cites W1607579928 @default.
- W2047707320 cites W1944970393 @default.
- W2047707320 cites W1965239527 @default.
- W2047707320 cites W1965756219 @default.
- W2047707320 cites W1972908305 @default.
- W2047707320 cites W1978374026 @default.
- W2047707320 cites W1981001162 @default.
- W2047707320 cites W2000272522 @default.
- W2047707320 cites W2011810742 @default.
- W2047707320 cites W2025025534 @default.
- W2047707320 cites W2035396914 @default.
- W2047707320 cites W2037985698 @default.
- W2047707320 cites W2047936759 @default.
- W2047707320 cites W2055308216 @default.
- W2047707320 cites W2057674485 @default.
- W2047707320 cites W2060164191 @default.
- W2047707320 cites W2062264009 @default.
- W2047707320 cites W2070216704 @default.
- W2047707320 cites W2071072548 @default.
- W2047707320 cites W2075511135 @default.
- W2047707320 cites W2080828132 @default.
- W2047707320 cites W2081074418 @default.
- W2047707320 cites W2084016050 @default.
- W2047707320 cites W2084147994 @default.
- W2047707320 cites W2084459589 @default.
- W2047707320 cites W2090827556 @default.
- W2047707320 cites W2093598492 @default.
- W2047707320 cites W2100837269 @default.
- W2047707320 cites W2105908798 @default.
- W2047707320 cites W2107943895 @default.
- W2047707320 cites W2110932995 @default.
- W2047707320 cites W2118607461 @default.
- W2047707320 cites W2131844826 @default.
- W2047707320 cites W2154247747 @default.
- W2047707320 cites W2161075664 @default.
- W2047707320 cites W2165443290 @default.
- W2047707320 cites W2330638116 @default.
- W2047707320 doi "https://doi.org/10.1002/jcb.20856" @default.
- W2047707320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16598776" @default.
- W2047707320 hasPublicationYear "2006" @default.
- W2047707320 type Work @default.
- W2047707320 sameAs 2047707320 @default.
- W2047707320 citedByCount "20" @default.
- W2047707320 countsByYear W20477073202012 @default.
- W2047707320 countsByYear W20477073202013 @default.
- W2047707320 countsByYear W20477073202015 @default.
- W2047707320 countsByYear W20477073202016 @default.
- W2047707320 countsByYear W20477073202018 @default.
- W2047707320 countsByYear W20477073202019 @default.
- W2047707320 crossrefType "journal-article" @default.
- W2047707320 hasAuthorship W2047707320A5014458386 @default.
- W2047707320 hasAuthorship W2047707320A5051231551 @default.
- W2047707320 hasAuthorship W2047707320A5072525622 @default.
- W2047707320 hasAuthorship W2047707320A5083316914 @default.
- W2047707320 hasConcept C153911025 @default.
- W2047707320 hasConcept C2776232574 @default.
- W2047707320 hasConcept C2776694085 @default.
- W2047707320 hasConcept C2776908312 @default.
- W2047707320 hasConcept C3675279 @default.
- W2047707320 hasConcept C54355233 @default.
- W2047707320 hasConcept C86803240 @default.
- W2047707320 hasConcept C95444343 @default.
- W2047707320 hasConceptScore W2047707320C153911025 @default.
- W2047707320 hasConceptScore W2047707320C2776232574 @default.
- W2047707320 hasConceptScore W2047707320C2776694085 @default.
- W2047707320 hasConceptScore W2047707320C2776908312 @default.
- W2047707320 hasConceptScore W2047707320C3675279 @default.
- W2047707320 hasConceptScore W2047707320C54355233 @default.
- W2047707320 hasConceptScore W2047707320C86803240 @default.
- W2047707320 hasConceptScore W2047707320C95444343 @default.
- W2047707320 hasIssue "1" @default.
- W2047707320 hasLocation W20477073201 @default.
- W2047707320 hasLocation W20477073202 @default.
- W2047707320 hasOpenAccess W2047707320 @default.
- W2047707320 hasPrimaryLocation W20477073201 @default.
- W2047707320 hasRelatedWork W2005186107 @default.
- W2047707320 hasRelatedWork W2079916634 @default.
- W2047707320 hasRelatedWork W2096529136 @default.
- W2047707320 hasRelatedWork W2158700235 @default.
- W2047707320 hasRelatedWork W2398786804 @default.
- W2047707320 hasRelatedWork W2415496605 @default.
- W2047707320 hasRelatedWork W2417610142 @default.
- W2047707320 hasRelatedWork W2989003100 @default.
- W2047707320 hasRelatedWork W3149524342 @default.
- W2047707320 hasRelatedWork W1979417022 @default.
- W2047707320 hasVolume "99" @default.
- W2047707320 isParatext "false" @default.
- W2047707320 isRetracted "false" @default.