Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047733982> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2047733982 endingPage "1124" @default.
- W2047733982 startingPage "1118" @default.
- W2047733982 abstract "Monocytes have been demonstrated to play an important role in acute serum sickness (AcSS) nephritis. Because accumulation of monocytes within the glomeruli could be the result of local lymphokine production, we studied migration inhibition factor (MIF) activity in supernatants from glomerular cultures, analyzed its temporal relationship with monocyte and lymphocyte accumulation, and tested the effect of anti-T lymphocyte monoclonal antibody on local MIF production. AcSS was induced in 12 rabbits, and one additional rabbit had antigen elimination without proteinuria. Single nephrectomy was performed at the time of antigen elimination in all animals; the remaining kidney was removed four days (4 rabbits) or 14 days afterwards (5 rabbits). In glomerular cross sections (gcs), lymphocytes were identified using monoclonal antibody M108, and monocytes by nonspecific esterase stain (ES). MIF activity was determined in supernatants of cultures of isolated glomeruli by the agarose microdroplet method. Peak of MIF activity (84.3 +/- 2.6%, SEM) was observed the first day of proteinuria in association with peak of lymphocyte infiltration (1.15 +/- 0.1 lymphocytes/gcs) and monocyte infiltration (2.4 +/- 0.3 mean ES score/gcs). MIF activity diminished by day 4 (66.0 +/- 6.3%) and reached control levels by day 14 (12.8 +/- 3.2%). There was a significant correlation between lymphocyte infiltration and MIF activity (r = 0.776, P less than 0.0001) as well as between MIF activity and monocyte accumulation (r = 0.858, P less than 0.0001). In five additional rabbits with AcSS, glomeruli were isolated, treated successively with M108 and normal rabbit serum, and supernatants harvested from 24-hour cultures were tested for MIF activity.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2047733982 created "2016-06-24" @default.
- W2047733982 creator A5030266408 @default.
- W2047733982 creator A5036235462 @default.
- W2047733982 creator A5036675059 @default.
- W2047733982 creator A5080294498 @default.
- W2047733982 date "1990-12-01" @default.
- W2047733982 modified "2023-10-18" @default.
- W2047733982 title "Migration inhibition factor in acute serum sickness nephritis" @default.
- W2047733982 cites W1583843090 @default.
- W2047733982 cites W1921933985 @default.
- W2047733982 cites W1934893658 @default.
- W2047733982 cites W1972361587 @default.
- W2047733982 cites W1994544731 @default.
- W2047733982 cites W1994723852 @default.
- W2047733982 cites W2002983094 @default.
- W2047733982 cites W2014323100 @default.
- W2047733982 cites W2050864904 @default.
- W2047733982 cites W2069144160 @default.
- W2047733982 cites W2069446585 @default.
- W2047733982 cites W2126600548 @default.
- W2047733982 cites W2329211716 @default.
- W2047733982 cites W361843664 @default.
- W2047733982 doi "https://doi.org/10.1038/ki.1990.321" @default.
- W2047733982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2074655" @default.
- W2047733982 hasPublicationYear "1990" @default.
- W2047733982 type Work @default.
- W2047733982 sameAs 2047733982 @default.
- W2047733982 citedByCount "8" @default.
- W2047733982 crossrefType "journal-article" @default.
- W2047733982 hasAuthorship W2047733982A5030266408 @default.
- W2047733982 hasAuthorship W2047733982A5036235462 @default.
- W2047733982 hasAuthorship W2047733982A5036675059 @default.
- W2047733982 hasAuthorship W2047733982A5080294498 @default.
- W2047733982 hasBestOaLocation W20477339821 @default.
- W2047733982 hasConcept C121332964 @default.
- W2047733982 hasConcept C126322002 @default.
- W2047733982 hasConcept C134018914 @default.
- W2047733982 hasConcept C147483822 @default.
- W2047733982 hasConcept C153400128 @default.
- W2047733982 hasConcept C159654299 @default.
- W2047733982 hasConcept C185592680 @default.
- W2047733982 hasConcept C203014093 @default.
- W2047733982 hasConcept C2777058396 @default.
- W2047733982 hasConcept C2777761686 @default.
- W2047733982 hasConcept C2779561371 @default.
- W2047733982 hasConcept C2779703309 @default.
- W2047733982 hasConcept C2780091579 @default.
- W2047733982 hasConcept C2781184567 @default.
- W2047733982 hasConcept C71924100 @default.
- W2047733982 hasConcept C97355855 @default.
- W2047733982 hasConceptScore W2047733982C121332964 @default.
- W2047733982 hasConceptScore W2047733982C126322002 @default.
- W2047733982 hasConceptScore W2047733982C134018914 @default.
- W2047733982 hasConceptScore W2047733982C147483822 @default.
- W2047733982 hasConceptScore W2047733982C153400128 @default.
- W2047733982 hasConceptScore W2047733982C159654299 @default.
- W2047733982 hasConceptScore W2047733982C185592680 @default.
- W2047733982 hasConceptScore W2047733982C203014093 @default.
- W2047733982 hasConceptScore W2047733982C2777058396 @default.
- W2047733982 hasConceptScore W2047733982C2777761686 @default.
- W2047733982 hasConceptScore W2047733982C2779561371 @default.
- W2047733982 hasConceptScore W2047733982C2779703309 @default.
- W2047733982 hasConceptScore W2047733982C2780091579 @default.
- W2047733982 hasConceptScore W2047733982C2781184567 @default.
- W2047733982 hasConceptScore W2047733982C71924100 @default.
- W2047733982 hasConceptScore W2047733982C97355855 @default.
- W2047733982 hasIssue "6" @default.
- W2047733982 hasLocation W20477339821 @default.
- W2047733982 hasLocation W20477339822 @default.
- W2047733982 hasOpenAccess W2047733982 @default.
- W2047733982 hasPrimaryLocation W20477339821 @default.
- W2047733982 hasRelatedWork W1899135655 @default.
- W2047733982 hasRelatedWork W1994723852 @default.
- W2047733982 hasRelatedWork W2000449888 @default.
- W2047733982 hasRelatedWork W2011092751 @default.
- W2047733982 hasRelatedWork W2042033030 @default.
- W2047733982 hasRelatedWork W2044943066 @default.
- W2047733982 hasRelatedWork W2047733982 @default.
- W2047733982 hasRelatedWork W2127085070 @default.
- W2047733982 hasRelatedWork W2328697141 @default.
- W2047733982 hasRelatedWork W2748952813 @default.
- W2047733982 hasVolume "38" @default.
- W2047733982 isParatext "false" @default.
- W2047733982 isRetracted "false" @default.
- W2047733982 magId "2047733982" @default.
- W2047733982 workType "article" @default.