FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2047755859> ?p ?o ?g. }

• W2047755859 abstract "Huntington's disease is a genetic neurological disorder that is triggered by the dissociation of the huntingtin protein (htt) from its obligate interaction partner Huntingtin-interacting protein 1 (HIP1). The release of the huntingtin protein permits HIP1 protein interactor (HIPPI) to bind to its recognition site on HIP1 to form a HIPPI/HIP1 complex that recruits procaspase-8 to begin the process of apoptosis. The interaction module between HIPPI and HIP1 was predicted to resemble a death-effector domain. Our 2.8-A crystal structure of the HIP1 371-481 subfragment that includes F432 and K474, which is important for HIPPI binding, is not a death-effector domain but is a partially opened coiled coil. The HIP1 371-481 model reveals a basic surface that we hypothesize to be suitable for binding HIPPI. There is an opened region next to the putative HIPPI site that is highly negatively charged. The acidic residues in this region are highly conserved in HIP1 and a related protein, HIP1R, from different organisms but are not conserved in the yeast homologue of HIP1, sla2p. We have modeled approximately 85% of the coiled-coil domain by joining our new HIP1 371-481 structure to the HIP1 482-586 model (Protein Data Bank code: 2NO2). Finally, the middle of this coiled-coil domain may be intrinsically flexible and suggests a new interaction model where HIPPI binds to a U-shaped HIP1 molecule." @default.
• W2047755859 created "2016-06-24" @default.
• W2047755859 creator A5020266538 @default.
• W2047755859 creator A5028304679 @default.
• W2047755859 date "2008-02-01" @default.
• W2047755859 modified "2023-09-26" @default.
• W2047755859 title "Crystal Structure at 2.8 Å of Huntingtin-Interacting Protein 1 (HIP1) Coiled-Coil Domain Reveals a Charged Surface Suitable for HIP1 Protein Interactor (HIPPI)" @default.
• W2047755859 cites W1822252127 @default.
• W2047755859 cites W1880823157 @default.
• W2047755859 cites W1911239883 @default.
• W2047755859 cites W1970277398 @default.
• W2047755859 cites W1977392771 @default.
• W2047755859 cites W1986308149 @default.
• W2047755859 cites W1991612575 @default.
• W2047755859 cites W1998602483 @default.
• W2047755859 cites W2013083986 @default.
• W2047755859 cites W2017470205 @default.
• W2047755859 cites W2024645073 @default.
• W2047755859 cites W2030410903 @default.
• W2047755859 cites W2030540514 @default.
• W2047755859 cites W2039526500 @default.
• W2047755859 cites W2059229862 @default.
• W2047755859 cites W2061216673 @default.
• W2047755859 cites W2066274736 @default.
• W2047755859 cites W2068366597 @default.
• W2047755859 cites W2077232274 @default.
• W2047755859 cites W2087261762 @default.
• W2047755859 cites W2088357437 @default.
• W2047755859 cites W2089584448 @default.
• W2047755859 cites W2093210405 @default.
• W2047755859 cites W2097992017 @default.
• W2047755859 cites W2104848919 @default.
• W2047755859 cites W2108677800 @default.
• W2047755859 cites W2112072636 @default.
• W2047755859 cites W2137511976 @default.
• W2047755859 cites W2138430231 @default.
• W2047755859 cites W2143694829 @default.
• W2047755859 cites W2144115944 @default.
• W2047755859 cites W2145881219 @default.
• W2047755859 cites W2150241436 @default.
• W2047755859 cites W2154117950 @default.
• W2047755859 cites W2171050418 @default.
• W2047755859 cites W4254605992 @default.
• W2047755859 doi "https://doi.org/10.1016/j.jmb.2007.11.036" @default.
• W2047755859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2271068" @default.
• W2047755859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18155047" @default.
• W2047755859 hasPublicationYear "2008" @default.
• W2047755859 type Work @default.
• W2047755859 sameAs 2047755859 @default.
• W2047755859 citedByCount "18" @default.
• W2047755859 countsByYear W20477558592012 @default.
• W2047755859 countsByYear W20477558592013 @default.
• W2047755859 countsByYear W20477558592014 @default.
• W2047755859 countsByYear W20477558592015 @default.
• W2047755859 countsByYear W20477558592017 @default.
• W2047755859 countsByYear W20477558592019 @default.
• W2047755859 countsByYear W20477558592020 @default.
• W2047755859 countsByYear W20477558592021 @default.
• W2047755859 crossrefType "journal-article" @default.
• W2047755859 hasAuthorship W2047755859A5020266538 @default.
• W2047755859 hasAuthorship W2047755859A5028304679 @default.
• W2047755859 hasBestOaLocation W20477558592 @default.
• W2047755859 hasConcept C104317684 @default.
• W2047755859 hasConcept C107824862 @default.
• W2047755859 hasConcept C119145174 @default.
• W2047755859 hasConcept C12554922 @default.
• W2047755859 hasConcept C143065580 @default.
• W2047755859 hasConcept C166998942 @default.
• W2047755859 hasConcept C185592680 @default.
• W2047755859 hasConcept C2781427258 @default.
• W2047755859 hasConcept C2910011555 @default.
• W2047755859 hasConcept C47701112 @default.
• W2047755859 hasConcept C51639874 @default.
• W2047755859 hasConcept C51785407 @default.
• W2047755859 hasConcept C55493867 @default.
• W2047755859 hasConcept C55988834 @default.
• W2047755859 hasConcept C65556437 @default.
• W2047755859 hasConcept C8010536 @default.
• W2047755859 hasConcept C86803240 @default.
• W2047755859 hasConcept C95444343 @default.
• W2047755859 hasConceptScore W2047755859C104317684 @default.
• W2047755859 hasConceptScore W2047755859C107824862 @default.
• W2047755859 hasConceptScore W2047755859C119145174 @default.
• W2047755859 hasConceptScore W2047755859C12554922 @default.
• W2047755859 hasConceptScore W2047755859C143065580 @default.
• W2047755859 hasConceptScore W2047755859C166998942 @default.
• W2047755859 hasConceptScore W2047755859C185592680 @default.
• W2047755859 hasConceptScore W2047755859C2781427258 @default.
• W2047755859 hasConceptScore W2047755859C2910011555 @default.
• W2047755859 hasConceptScore W2047755859C47701112 @default.
• W2047755859 hasConceptScore W2047755859C51639874 @default.
• W2047755859 hasConceptScore W2047755859C51785407 @default.
• W2047755859 hasConceptScore W2047755859C55493867 @default.
• W2047755859 hasConceptScore W2047755859C55988834 @default.
• W2047755859 hasConceptScore W2047755859C65556437 @default.
• W2047755859 hasConceptScore W2047755859C8010536 @default.
• W2047755859 hasConceptScore W2047755859C86803240 @default.
• W2047755859 hasConceptScore W2047755859C95444343 @default.
• W2047755859 hasLocation W20477558591 @default.
• W2047755859 hasLocation W20477558592 @default.

• next