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- W2047771618 abstract "Gut-associated lymphoid tissue (GALT) is the primary replication site for HIV-1, resulting in a pronounced CD4+ T cell loss in this tissue during primary infection. A mucosal vaccine that generates HIV-specific CD8+ T cells in the gut could prevent the establishment of founder populations and broadcasting of virus. Here, we immunized mice orally and systemically with a chimpanzee derived adenoviral vector expressing HIV gag (AdC68gag) and measured frequencies of gag-specific interferon-gamma (IFN-γ) producing CD8+ T cells in the GALT. A single oral administration was inefficient at eliciting responses in the mesenteric lymph nodes and Peyer's Patches, while a single intramuscular administration elicited strong systemic and detectable mucosal responses. The gag-specific CD8+ T cell responses were present in both acute and memory phases following intramuscular administration." @default.
- W2047771618 created "2016-06-24" @default.
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- W2047771618 creator A5052194834 @default.
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- W2047771618 date "2007-03-01" @default.
- W2047771618 modified "2023-10-11" @default.
- W2047771618 title "Intramuscular rather than oral administration of replication-defective adenoviral vaccine vector induces specific CD8+ T cell responses in the gut" @default.
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- W2047771618 doi "https://doi.org/10.1016/j.vaccine.2006.11.044" @default.
- W2047771618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1839821" @default.
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- W2047771618 hasPublicationYear "2007" @default.
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